Subtypes of the type 4 cAMP phosphodiesterases: structure, regulation and selective inhibition

A Family of Human Phosphodiesterases Homologous to the Dunce Learning and Memory Gene Product of Drosophila melanogaster are Potential Targets for Antidepressant Drugs

1993 • 287 citations

Stereospecific binding of the antidepressant rolipram to brain protein structures

1986 • 235 citations

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.

1993 • 233 citations

Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase.

1989 • 192 citations

Biarylcarboxylic Acids and -amides: Inhibition of Phosphodiesterase Type IV versus [³H]Rolipram Binding Activity and Their Relationship to Emetic Behavior in the Ferret

1996 • 142 citations

The mRNA encoding a high-affinity cAMP phosphodiesterase is regulated by hormones and cAMP.

1989 • 142 citations

Coexpression of human cAMP-specific phosphodiesterase activity and high affinity rolipram binding in yeast.

1992 • 139 citations

Expression and regulation of human and rat phosphodiesterase type IV isogenes

1994 • 139 citations

Molecular biology of the cyclic AMP-specific cyclic nucleotide phosphodiesterases: A diverse family of regulatory enzymes

1994 • 135 citations

Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram

1993 • 133 citations

Cloning and expression of cDNA for a human low-Km, rolipram-sensitive cyclic AMP phosphodiesterase.

1990 • 133 citations

The ratPDE3/IVd phosphodiesterase gene codes for multiple proteins differentially activated by cAMP-dependent protein kinase

1994 • 132 citations

Properties and hormonal regulation of two structurally related cAMP phosphodiesterases from the rat Sertoli cell.

1991 • 130 citations

A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA.

1993 • 130 citations

Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3.

1995 • 127 citations

Characterization of the structure of a low Km, rolipram-sensitive cAMP phosphodiesterase. Mapping of the catalytic domain.

1992 • 113 citations

Differential CNS expression of alternative mRNA isoforms of the mammalian genes encoding cAMP-specific phosphodiesterases

1994 • 108 citations

Inhibitors of phosphodiesterase IV (PDE IV) increase acid secretion in rabbit isolated gastric glands: correlation between function and interaction with a high-affinity rolipram binding site.

1995 • 102 citations

Identification and characterization of the type-IVA cyclic AMP-specific phosphodiesterase RD1 as a membrane-bound protein expressed in cerebellum

1995 • 93 citations

Structure of two rat genes coding for closely related rolipram-sensitive cAMP phosphodiesterases. Multiple mRNA variants originate from alternative splicing and multiple start sites.

1994 • 92 citations

Prolonged beta adrenoceptor stimulation up-regulates cAMP phosphodiesterase activity in human monocytes by increasing mRNA and protein for phosphodiesterases 4A and 4B.

1996 • 85 citations

Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase

1991 • 85 citations

Suppression of eosinophil function by RP 73401, a potent and selective inhibitor of cyclic AMP‐specific phosphodiesterase: comparison with rolipram

1995 • 84 citations

Molecular cloning and functional expression in yeast of a human cAMP‐specific phosphodiesterase subtype (PDE IV‐C)

1995 • 74 citations

Close correlation between behavioural response and binding in vivo for inhibitors of the rolipram-sensitive phosphodiesterase

1990 • 66 citations

Brain distribution of four rat homologues of the drosophila dunce cAMP phosphodiesterase

1995 • 61 citations

Use of a yeast expression system for the isolation and analysis of drug-resistant mutants of a mammalian phosphodiesterase.

1993 • 56 citations

The ability of phosphodiesterase IV inhibitors to suppress superoxide production in guinea pig eosinophils is correlated with inhibition of phosphodiesterase IV catalytic activity.

1995 • 53 citations

Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse

1994 • 48 citations

Isolation of a cDNA encoding a human rolipram-sensitive cyclic AMP phosphodiesterase (PDE IVD)

1994 • 46 citations

Stage and cell-specific expression of the adenosine 3',5' monophosphate-phosphodiesterase genes in the rat seminiferous epithelium.

1995 • 46 citations

Acute versus chronic administration of phosphodiesterase inhibitors on allergen‐induced pulmonary cell influx in sensitized guinea‐pigs

1995 • 46 citations

Molecular cloninc and expression, in both COS-1 cells and S. cerevisiae, of a human cytosolic type-IVA cyclic AMP specific phosphodiesterase (hPDE-IVA-h6.1)

1994 • 46 citations

Purification, characterization and analysis of rolipram inhibition of a human type-IVA cyclic AMP-specific phosphodiesterase expressed in yeast

1994 • 45 citations

Behavioral effects of rolipram and structurally related compounds in mice: Behavioral sedation of cAMP phosphodiesterase inhibitors

1991 • 43 citations

Molecular cloning of a novel splice variant of human type IVA (PDE-IVA) cyclic AMP phosphodiesterase and localization of the gene to the p13.2-q12 region of human chromosome 19

1995 • 42 citations

Chromosomal localization of the human and rat genes (PDE4D and PDE4B) encoding the cAMP-specific phosphodiesterases 3 and 4

1995 • 38 citations

Inhibition of Cyclic Nucleotide Phosphodiesterase by Derivatives of 1,3-Bis(cyclopropylmethyl)xanthine

1994 • 33 citations

Phosphodiesterase IV inhibitors as therapy for eosinophil-induced lung injury in asthma.

1994 • 31 citations

Stage and cell-specific expression of the adenosine 3',5' monophosphate- phosphodiesterase genes in the rat seminiferous epithelium

1995 • 16 citations

Discriminative stimulus properties of the stereoisomers of the phosphodiesterase inhibitor rolipram

1995 • 15 citations

The selective inhibition of phosphodiesterase IV by benzopyran derivatives of rolipram

1993 • 15 citations

Characterization of two human cAMP‐specific phosphodiesterase subtypes expressed in baculovirus‐infected insect cells.

1995 • 11 citations

Phosphodiesterase IV Inhibitors as Therapy for Eosinophil-Induced Lung Injury in Asthma

1994 • 4 citations