PDE 4 inhibitors: the use of molecular cloning in the design and development of novel drugs

A Family of Human Phosphodiesterases Homologous to the Dunce Learning and Memory Gene Product of Drosophila melanogaster are Potential Targets for Antidepressant Drugs

1993 • 287 citations

Stereospecific binding of the antidepressant rolipram to brain protein structures

1986 • 235 citations

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.

1993 • 233 citations

4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone (ZK 62711): a potent inhibitor of adenosine cyclic 3',5'-monophosphate phosphodiesterases in homogenates and tissue slices from rat brain.

1976 • 222 citations

Rolipram in Major Depressive Disorder: Results of a Double-Blind Comparative Study with Imipramine

1989 • 155 citations

Biarylcarboxylic Acids and -amides: Inhibition of Phosphodiesterase Type IV versus [³H]Rolipram Binding Activity and Their Relationship to Emetic Behavior in the Ferret

1996 • 142 citations

Coexpression of human cAMP-specific phosphodiesterase activity and high affinity rolipram binding in yeast.

1992 • 139 citations

Expression and regulation of human and rat phosphodiesterase type IV isogenes

1994 • 139 citations

Excitation of area postrema neurons by transmitters, peptides, and cyclic nucleotides

1988 • 134 citations

The ratPDE3/IVd phosphodiesterase gene codes for multiple proteins differentially activated by cAMP-dependent protein kinase

1994 • 132 citations

A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA.

1993 • 130 citations

cAMP and human neutrophil chemotaxis. Elevation of cAMP differentially affects chemotactic responsiveness.

1991 • 128 citations

Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3.

1995 • 127 citations

Inhibition of antigen-induced bronchoconstriction and eosinophil infiltration in the guinea pig by the cyclic AMP-specific phosphodiesterase inhibitor, rolipram.

1993 • 127 citations

Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNFα generation from human monocytes by interacting with a ‘low‐affinity’ phosphodiesterase 4 conformer

1996 • 113 citations

Role of low Km cyclic AMP phosphodiesterase inhibition in tracheal relaxation and bronchodilation in the guinea pig.

1989 • 110 citations

Anti‐inflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type IV inhibitor

1994 • 110 citations

Differential CNS expression of alternative mRNA isoforms of the mammalian genes encoding cAMP-specific phosphodiesterases

1994 • 108 citations

Characterization of the memory gene dunce of Drosophila melanogaster

1991 • 105 citations

Association of the anti-inflammatory activity of phosphodiesterase 4 (PDE4) inhibitors with either inhibition of PDE4 catalytic activity or competition for [3H]rolipram binding

1996 • 104 citations

Differential effects of non‐selective and selective phosphodiesterase inhibitors on human eosinophil functions

1995 • 102 citations

Inhibitors of phosphodiesterase IV (PDE IV) increase acid secretion in rabbit isolated gastric glands: correlation between function and interaction with a high-affinity rolipram binding site.

1995 • 102 citations

Effects of rolipram on responses to acute and chronic antigen exposure in monkeys.

1994 • 101 citations

The inhibition of antigen‐induced eosinophilia and bronchoconstriction by CDP840, a novel stereo‐selective inhibitor of phosphodiesterase type 4

1996 • 95 citations

Is Phosphodiesterase inhibition a new mechanism of antidepressant action?

1988 • 93 citations

Suppression of human eosinophil respiratory burst and cyclic AMP hydrolysis by inhibitors of type IV phosphodiesterase: interaction with the beta adrenoceptor agonist albuterol.

1994 • 86 citations

Suppression of eosinophil function by RP 73401, a potent and selective inhibitor of cyclic AMP‐specific phosphodiesterase: comparison with rolipram

1995 • 84 citations

Bronchodilatory effect of inhaled zardaverine, a phosphodiesterase III and IV inhibitor, in patients with asthma

1992 • 80 citations

On the medical history of xanthines and other remedies for asthma: a tribute to HH Salter.

1985 • 74 citations

Selective inhibition of one of the cyclic AMP phosphodiesterases from rat brain by the neurotropic compound rolipram

1985 • 55 citations

The ability of phosphodiesterase IV inhibitors to suppress superoxide production in guinea pig eosinophils is correlated with inhibition of phosphodiesterase IV catalytic activity.

1995 • 53 citations

Comparison of the effects of selective inhibitors of phosphodiesterase types III and IV in airway smooth muscle with differing β‐adrenoceptor subtypes

1993 • 51 citations

Inhibition of bronchospasm and ozone‐induced airway hyperresponsiveness in the guinea‐pig by CDP840, a novel phosphodiesterase type 4 inhibitor

1996 • 48 citations

Effect of the glucocorticosteroid budesonide and a novel phosphodiesterase type 4 inhibitor CDP840 on antigen‐induced airway responses in neonatally immunised rabbits

1996 • 45 citations

EEG Mapping and psychopharmacological studies with denbufylline in SDAT and MID

1992 • 45 citations

Identification of cyclic AMP‐phosphodiesterase variants from the PDE4D gene expressed in human peripheral mononuclear cells

1996 • 40 citations

Effects of theophylline and rolipram on antigen‐induced airway responses in neonatally immunized rabbits

1996 • 39 citations

Effects of solubilization and vanadate/glutathione complex on inhibitor potencies against eosinophil cyclic AMP‐specific phosphodiesterase

1992 • 37 citations

Rolipram, but not siguazodan or zaprinast, inhibits the excitatory noncholinergic neurotransmission in guinea-pig bronchi

1994 • 35 citations

THERAPEUTIC IMMUNOLOGY

1996 • 29 citations

Inhibition of neurally mediated nonadrenergic, noncholinergic contractions of guinea pig bronchus by isozyme-selective phosphodiesterase inhibitors.

1994 • 28 citations

Purification of cAMP-specific phosphodiesterase from rat heart by affinity chromatography on immobilized rolipram

1986 • 17 citations

Characterization of two human cAMP‐specific phosphodiesterase subtypes expressed in baculovirus‐infected insect cells.

1995 • 11 citations

Criteria for judging proposals for national health care reform with respect to therapeutics

1994 • 3 citations

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