Treatment with tumour necrosis factor inhibitor oxpentifylline does not improve corticosteroid dependent chronic active Crohn's disease.

The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection

1989 • 1,269 citations

National Cooperative Crohn's Disease Study: Results of drug treatment

1979 • 1,257 citations

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF

1988 • 1,105 citations

Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2)

1995 • 1,103 citations

The Role of Interleukin-1 in Disease

1993 • 967 citations

European Cooperative Crohn's Disease Study (ECCDS): Results of drug treatment

1984 • 951 citations

Enhand secretion of tumour necrosis factor-alpha, IL-6, and IL-1β by isolated lamina ropria monouclear cells from patients with ulcretive cilitis and Crohn's disease

1993 • 848 citations

Development and validation of an endoscopic index of the severity for Crohn's disease: a prospective multicentre study. Groupe d'Etudes Therapeutiques des Affections Inflammatoires du Tube Digestif (GETAID).

1989 • 833 citations

Tumour necrosis factor alpha in stool as a marker of intestinal inflammation

1992 • 700 citations

Chimeric anti-TNF-α monoclonal antibody cA2 binds recombinant transmembrane TNF-α and activates immune effector functions

1995 • 693 citations

Tumor necrosis factor α-producing cells in the intestinal mucosa of children with inflammatory bowel disease

1994 • 578 citations

Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxofylline

1988 • 564 citations

Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway.

1990 • 509 citations

Serum concentrations of tumour necrosis factor alpha in childhood chronic inflammatory bowel disease.

1991 • 491 citations

Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine

1990 • 489 citations

Characterization of a cancer cachectic factor

1996 • 442 citations

Enhanced production of interleukin 1-beta by mononuclear cells isolated from mucosa with active ulcerative colitis of Crohn's disease.

1989 • 430 citations

Tumour necrosis factor α restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice

1992 • 424 citations

Role of interleukin 1 in inflammatory bowel disease--enhanced production during active disease.

1990 • 402 citations

Tumor necrosis factor-?, interleukin-1?, and interleukin-6 expression in inflammatory bowel disease

1992 • 325 citations

Cytokine messenger RNA profiles in inflammatory bowel disease mucosa detected by polymerase chain reaction amplification

1992 • 323 citations

Bowel necrosis induced by tumor necrosis factor in rats is mediated by platelet-activating factor.

1988 • 300 citations

Effect of tumor necrosis factor on epithelial tight junctions and transepithelial permeability.

1990 • 224 citations

Increased activation of isolated intestinal lamina propria mononuclear cells in inflammatory bowel disease

1991 • 207 citations

Phase I-II trial of pentoxifylline for the prevention of transplant- related toxicities following bone marrow transplantation [published erratum appears in Blood 1992 Jun 15;79(12):3397] [see comments]

1991 • 200 citations

Triggered human mucosal T cells release tumour necrosis factor-alpha and interferon-gamma which kill human colonic epithelial cells

1991 • 149 citations

Detection of mRNAs for macrophage products in inflammatory bowel disease by in situ hybridisation.

1992 • 138 citations

Prevention of regimen-related toxicities after bone marrow transplantation by pentoxifylline: a prospective, randomized trial

1993 • 109 citations

Impaired response of activated mononuclear phagocytes to interleukin 4 in inflammatory bowel disease

1995 • 109 citations

Pentoxifylline decreases tumor necrosis factor expression and serum triglycerides in people with AIDS. NIAID AIDS Clinical Trials Group.

1993 • 88 citations

Pentoxifylline decreases body weight loss and muscle protein wasting characteristics of sepsis

1993 • 78 citations

The Role of Interleukin-1 in Disease

1993 • 73 citations

IMMUNE RESPONSE MODULATION BY PENTOXIFYLLINE IN VITRO

1993 • 66 citations

Pentoxifylline attenuates neutrophil activation in experimental endotoxemia in chimpanzees.

1993 • 64 citations

Tumor Necrosis Factor-α Is Not Elevated in Children with Inflammatory Bowel Disease

1991 • 64 citations

Inflammatory properties of recombinant tumor necrosis factor in rabbit skin in vivo.

1989 • 63 citations

Interleukin-1 and tumor necrosis factor and their naturally occurring antagonists during hemodialysis.

1992 • 59 citations

Mesalamine capsules enhance the quality of life for patients with ulcerative colitis

1994 • 35 citations

Pentoxifylline inhibits integrin-mediated adherence of interleukin-2- activated human peripheral blood lymphocytes to human umbilical vein endothelial cells, matrix components, and cultured tumor cells

1994 • 26 citations

Prevention of regimen-related toxicities after bone marrow transplantation by pentoxifylline: a prospective, randomized trial

1993 • 6 citations

Increased secretion of pro-inflammatory cytokines by LPMNC is a predictor for relapse of IBD

1995 • 1 citations