Novel Heterocyclic-Fused Pyridazinones as Potent and Selective Phosphodiesterase IV Inhibitors

Comprehensive medicinal chemistry

1991 • 278 citations

Stereospecific binding of the antidepressant rolipram to brain protein structures

1986 • 235 citations

Annual Reports in Medicinal Chemistry

2009 • 190 citations

Multiple high-affinity cAMP-phosphodiesterases in human T-lymphocytes

1991 • 130 citations

Characterization of guinea-pig eosinophil phosphodiesterase activity

1991 • 108 citations

Identification of two splice variant forms of type-IVB cyclic AMP phosphodiesterase, DPD (rPDE-IVB1) and PDE-4 (rPDE-IVB2) in brain: selective localization in membrane and cytosolic compartments and differential expression in various brain regions

1994 • 88 citations

Assessment of selective inhibition of rat cerebral cortical calcium-independent and calcium-dependent phosphodiesterases in crude extracts using deoxycyclic AMP and potassium ions

1984 • 75 citations

Clinical pharmacology of corticosteroids in bronchial asthma

1993 • 73 citations

DEAMINIZATION.¹ III. EVIDENCE OF THE EXISTENCE OF ALIPHATIC DIAZONIUM SALTS FROM THE FORMATION OF CHLORO-OXIMINO COMPOUNDS

1924 • 68 citations

Autoradiographic mapping of a selective cyclic adenosine monophosphate phosphodiesterase in rat brain with the antidepressant [3H]rolipram

1989 • 63 citations

4,5-Functionalized 6-phenyl-3(2H)-pyridazinones: synthesis and evaluation of antinociceptive activity

1996 • 61 citations

Inhibition of prostaglandin E2-stimulated cAMP accumulation by lipopolysaccharide in murine peritoneal macrophages

1991 • 47 citations

Progress in Medicinal Chemistry

1996 • 45 citations

Synthesis and in vitro profile of a novel series of catechol benzimidazoles. The discovery of potent, selective phosphodiesterase type IV inhibitors with greatly attenuated affinity for the [3H]rolipram binding site

1995 • 44 citations

TVX 2706 — a new phosphodiesterase inhibitor with antiinflammatory action Biochemical characterization

1984 • 36 citations

Studies on the cardiac actions of flosequinan in vitro

1992 • 27 citations

THE ALKYLATION OF PRIMARY AMINES WITH ALUMINUM ALKOXIDES TO GIVE SECONDARY AMINES FREE FROM TERTIARY AMINES

1924 • 14 citations