Protection from T cell-mediated murine liver failure by phosphodiesterase inhibitors.

IL-10 inhibits cytokine production by activated macrophages.

1991 • 2,919 citations

Macrophage deactivation by interleukin 10.

1991 • 1,253 citations

A T cell-dependent experimental liver injury in mice inducible by concanavalin A.

1992 • 1,041 citations

Galactosamine-induced sensitization to the lethal effects of endotoxin.

1979 • 940 citations

T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor.

1992 • 595 citations

Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated mice.

1987 • 560 citations

T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6.

1994 • 519 citations

Concanavalin A?induced T-cell?Mediated hepatic injury in mice: The role of tumor necrosis factor*1

1995 • 481 citations

Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A

1996 • 421 citations

Regulation of tumor necrosis factor production by adrenaline and beta-adrenergic agonists.

1992 • 385 citations

The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis

1995 • 345 citations

Tumor Necrosis Factor: The molecules and Their Emerging Role in Medicine

1992 • 330 citations

Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide.

1994 • 325 citations

Up-regulation of monocytic IL-10 by tumor necrosis factor-α and cAMP elevating drugs

1995 • 318 citations

Tumor necrosis factor is a terminal mediator in galactosamine/endotoxin-induced hepatitis in mice

1989 • 304 citations

Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes.

1992 • 258 citations

Cholera toxin discriminates between T helper 1 and 2 cells in T cell receptor-mediated activation: role of cAMP in T cell proliferation.

1990 • 238 citations

cAMP inhibits induction of interleukin 2 but not of interleukin 4 in T cells.

1990 • 218 citations

Inhibition of endogenous TNF formation by pentoxifylline

1993 • 182 citations

Prevention of autoimmune demyelination in non-human primates by a cAMP-specific phosphodiesterase inhibitor.

1995 • 178 citations

Interleukin 10 protects mice against staphylococcal enterotoxin B-induced lethal shock

1993 • 166 citations

Cyclic nucleotide phosphodiesterase type IV participates in the regulation of IL-10 and in the subsequent inhibition of TNF-alpha and IL-6 release by endotoxin-stimulated macrophages.

1995 • 159 citations

Immunosuppressive retroviral peptides: cAMP and cytokine patterns

1995 • 153 citations

Xanthine derivatives: comparison between suppression of tumour necrosis factor-alpha production and inhibition of cAMP phosphodiesterase activity.

1993 • 140 citations

Characterization of cAMP-dependent inhibition of LPS-induced TNFα production by rolipram, a specific phosphodiesterase IV (PDE IV) inhibitor

1994 • 136 citations

Suppression of lipopolysaccharide-induced tumor necrosis factor-alpha generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4: interaction with stimulants of adenylyl cyclase.

1995 • 129 citations

Lipopolysaccharide‐induced interleukin‐10 in mice: role of endogenous tumor necrosis factor‐α

1995 • 128 citations

Systemic release and protective role of IL-10 in staphylococcal enterotoxin B-induced shock in mice.

1994 • 127 citations

Hepatic injury and lethal shock in galactosamine-sensitized mice induced by the superantigen staphylococcal enterotoxin B

1994 • 104 citations

IL-10 is involved in the protective effect of dibutyryl cyclic adenosine monophosphate on endotoxin-induced inflammatory liver injury.

1995 • 96 citations

Tumor necrosis factor-induced hepatic DNA fragmentation as an early marker of T cell-dependent liver injury in mice

1995 • 94 citations

cAMP up-regulates IL-4 and IL-5 production from activated CD4⁺ T cells while decreasing IL-2 release and NF-AT induction

1994 • 93 citations

cAMP activates the IL-5 promoter synergistically with phorbol ester through the signaling pathway involving protein kinase A in mouse thymoma line EL-4.

1993 • 92 citations

Calcineurin mediates human tumor necrosis factor alpha gene induction in stimulated T and B cells.

1994 • 92 citations

Suppression of lipopolysaccharide-stimulated release of tumor necrosis factor by adenosine: Evidence for A2 receptors on rat kupffer cells

1994 • 82 citations

Modulation of antigen- and mitogen-induced proliferative responses of peripheral blood mononuclear cells by nonselective and isozyme selective cyclic nucleotide phosphodiesterase inhibitors.

1994 • 82 citations

Cyclic nucleotide phosphodiesterases from purified human CD4⁺ and CD8⁺ T lymphocytes

1995 • 79 citations

Modulation of TNFα and IL-1β from endotoxin-stimulated monocytes by selective PDE isozyme inhibitors

1993 • 66 citations

The specific type III and IV phosphodiesterase inhibitor zardaverine suppresses formation of tumor necrosis factor by macrophages

1993 • 61 citations

Tumour necrosis factor: clinical relevance.

1989 • 48 citations

Protection by phosphodiesterase inhibitors against endotoxin-induced liver injury in galactosamine-sensitized mice

1993 • 44 citations

Enhanced release of interleukin-10 and soluble tumor necrosis factor receptors as novel principles of methylxanthine action in murine models of endotoxic shock.

1996 • 37 citations

Leukocyte alterations do not account for hepatitis induced by endotoxin or TNFα in galactosamine-sensitized mice

1990 • 33 citations

Effect of phosphodiesterase inhibition on IL-4 and IL-5 production of the murine TH2-type t cell clone D10.G4.1

1995 • 28 citations

[74] Biochemical pharmacology of inflammatory liver injury in mice

1990 • 25 citations

Tumor necrosis factor production in the perfused mouse liver and its pharmacological modulation by methylxanthines.

1996 • 18 citations

Separation and Assay of Phosphodiesterase Isoforms in Murine Peritoneal Macrophages Using Membrane Matrix DEAE Chromatography and [32P]cAMP

1993 • 9 citations