Developmental Regulation of the Insulin and Insulin-Like Growth Factor Receptors in the Central Nervous System

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations*

1989 • 1,796 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action.

1984 • 1,171 citations

Insulin receptors are widely distributed in the central nervous system of the rat

1978 • 1,092 citations

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

1979 • 1,089 citations

Insulin-like growth factor II receptor as a multifunctional binding protein

1987 • 858 citations

Somatomedin-C Mediates Growth Hormone Negative Feedback by Effects on Both the Hypothalamus and the Pituitary

1981 • 829 citations

The Nature and Regulation of the Receptors for Insulin-Like Growth Factors

1985 • 639 citations

Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas

1986 • 416 citations

Insulin receptors in the central nervous system: Localization, signalling mechanisms and functional aspects

1991 • 386 citations

Insulin-like growth factor I/somatomedin C: a potent inducer of oligodendrocyte development.

1986 • 383 citations

Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: Comparison with insulin-like growth factors I and II

1992 • 370 citations

Structure of the human insulin receptor gene and characterization of its promoter.

1989 • 349 citations

Developmental regulation of the rat insulin-like growth factor I receptor gene.

1989 • 338 citations

Insulin and insulin-like growth factors in the CNS

1988 • 334 citations

Cellular Pattern of Insulin-Like Growth Factor-I (IGF-I) and Type I IGF Receptor Gene Expression in Early Organogenesis: Comparison with IGF-II Gene Expression

1990 • 320 citations

Expression and characterization of a functional human insulin-like growth factor I receptor.

1988 • 313 citations

A simple structure encodes G protein-activating function of the IGF-II/mannose 6-phosphate receptor

1990 • 278 citations

Insulin-like Growth Factor I Receptor β-Subunit Heterogeneity

1989 • 259 citations

Insulin binds to specific receptors and stimulates 2-deoxy-D-glucose uptake in cultured glial cells from rat brain.

1984 • 255 citations

Interactions of Insulin-Like Growth Factors I and II and Multiplication-Stimulating Activity with Receptors and Serum Carrier Proteins

1980 • 254 citations

Receptors for Insulin-like Growth Factors I and II: Autoradiographic Localization in Rat Brain and Comparison to Receptors for Insulin*

1988 • 252 citations

Insulin-like growth factor I (IGF I) stimulates DNA synthesis in fetal rat brain cell cultures

1983 • 230 citations

Insulin-like Growth Factors: Molecular and Cellular Aspects

1992 • 214 citations

Insulin and insulin-like growth factor receptors in the nervous system

1989 • 207 citations

Characterization of Insulin-Like Growth Factor Receptors in Rat Anterior Pituitary, Hypothalamus, and Brain*

1984 • 199 citations

Ontogenesis of somatomedin and insulin receptors in the human fetus.

1983 • 197 citations

Immunological relationships between receptors for insulin and insulin-like growth factor I. Evidence for structural heterogeneity of insulin-like growth factor I receptors involving hybrids with insulin receptors

1989 • 196 citations

Insulin receptors and insulin modulation of norepinephrine uptake in neuronal cultures from rat brain.

1985 • 195 citations

Insulin-like growth factor I receptors in neuronal and glial cells. Characterization and biological effects in primary culture.

1987 • 190 citations

An infant with deletion of the distal long arm of chromosome 15 (q26.1→qter) and loss of insulin‐like growth factor 1 receptor gene

1991 • 179 citations

Insulin inhibits pyramidal neurons in hippocampal slices

1984 • 176 citations

Characterization of somatomedins from human fetal brain: identification of a variant form of insulin-like growth factor I.

1986 • 166 citations

Two types of receptor for insulin-like growth factors in mammalian brain.

1985 • 163 citations

Human blood-brain barrier insulin-like growth factor receptor

1988 • 155 citations

Insulin-like growth factor-1 (somatomedin-C) receptors in the rat brain: distribution and interaction with the hippocampal cholinergic system

1989 • 148 citations

Insulin‐like growth factor (IGF) binding to human fibroblast and glioblastoma cells: The modulating effect of cell released IGF binding proteins (IGFBPs)

1990 • 143 citations

Insulin-like growth factor I in cultured rat astrocytes: expression of the gene, and receptor tyrosine kinase.

1987 • 141 citations

Localization of Insulin-Like Growth Factor-I mRNA in Rat Brain byin SituHybridization—Relationship to IGF-I Receptors

1990 • 140 citations

Characterization of a neuronal subtype of insulin-like growth factor I receptor.

1987 • 132 citations

Characterization of High Affinity Receptors for Insulin-Like Growth Factors I and II on Rat Anterior Pituitary Cells*

1984 • 128 citations

Isolation of a Drosophila genomic sequence homologous to the kinase domain of the human insulin receptor and detection of the phosphorylated Drosophila receptor with an anti-peptide antibody.

1986 • 123 citations

Insulin-like growth factor 1 (IGF-1) receptors in the human brain: quantitative autoradiographic localization

1989 • 122 citations

Regulation of Rat Brain/HepG2 Glucose Transporter Gene Expression by Insulin and Insulin-Like Growth Factor-I in Primary Cultures of Neuronal and Glial Cells*

1989 • 122 citations

Expression of IGF‐I and insulin receptor genes in the rat central nervous system: A developmental, regional, and cellular analysis

1991 • 121 citations

Insulin and Insulin-Like Growth Factor I in Early Development: Peptides, Receptors and Biological Events*

1990 • 120 citations

Insulin-Like Growth Factor I Messenger Ribonucleic Acids with Alternative 5'-Untranslated Regions Are Differentially Expressed during Development of the Rat

1989 • 117 citations

Development of Brain Insulin Receptors: Structural and Functional Studies of Insulin Receptors from Whole Brain and Primary Cell Cultures*

1986 • 116 citations

Ontogeny of Receptors for Insulin-Like Peptides in Chick Embryo Tissues: Early Dominance of Insulin-Like Growth Factor over Insulin Receptors in Brain*

1985 • 116 citations

Characterization of somatomedin/insulin-like growth factor receptors and correlation with biologic action in cultured neonatal rat astroglial cells

1987 • 107 citations

Insulin and insulinlike growth factor receptors regulating neurite formation in cultured human neuroblastoma cells

1988 • 106 citations

Developmental Expression of the Tissue Insulin-like Growth Factor II/Mannose 6-Phosphate Receptor in the Rat

1989 • 102 citations

Quantitative Autoradiographic Evidence for Insulin Receptors in the Choroid Plexus of the Rat Brain

1986 • 98 citations

Unique Features of the Insulin Receptor in Rat Brain

1984 • 96 citations

Insulin Binding in Four Regions of the Developing Rat Brain

1984 • 96 citations

Intrahypothalamic injection of insulin decreases firing rate of sympathetic nerves.

1987 • 88 citations

Insulin and insulinlike growth factor 1 (IGF-1) receptors during central nervous system development: expression of two immunologically distinct IGF-1 receptor beta subunits.

1989 • 84 citations

Structural and Immunohistochemical Characterization of Insulin-Like Growth Factor I and II Receptors in the Murine Central Nervous System*

1988 • 84 citations

Receptor Binding, Endocytosis, and Mitogenesis of Insulin‐Like Growth Factors I and II in Fetal Rat Brain Neurons

1991 • 83 citations

Radiohistochemical localization of insulin receptors in the adult and developing rat brain

1980 • 83 citations

Rat C6 Glial Cells Synthesize Insulin-Like Growth Factor I (IGF-I) and Express IGF-I Receptors and IGF-II/ Mannose 6-Phosphate Receptors*

1989 • 80 citations

Genes encoding receptors for insulin and insulin-like growth factor I are expressed in Xenopus oocytes and embryos.

1991 • 77 citations

Purification and characterization of the human brain insulin receptor.

1986 • 76 citations

Tissue localization of Drosophila melanogaster insulin receptor transcripts during development.

1988 • 75 citations

Insulin receptors in the brain: Structural and physiological characterization

1988 • 67 citations

Demonstration and structural comparison of receptors for insulin-like growth factor-I and -II (IGF-I and -II) in brain and blood-brain barrier

1987 • 66 citations

Developmental Regulation of Insulin and Type I Insulin-Like Growth Factor Receptors and Absence of Type II Receptors in Chicken Embryo Tissues

1988 • 64 citations

Insulin receptors and insulin action in dissociated brain cells

1987 • 61 citations

Insulin-Like Growth Factor-I Receptors in Human Glial Tumors

1990 • 59 citations

Insulin receptors in rat brain cortex. Kinetic evidence for a receptor subtype in the central nervous system

1984 • 58 citations

The insulin-like growth factor-II (IGF-II) receptor of rat brain: regional distribution visualized by autoradiography

1988 • 56 citations

Insulin, Insulin-like Growth Factors, and Their Receptors in the Central Nervous System

1987 • 55 citations

Insulin‐like growth factor I receptors on mouse neuroblastoma cells

1988 • 53 citations

A Comparison of the Insulin and Insulin-Like Growth Factor I Receptors from Rat Brain and Liver*

1988 • 52 citations

In situ autoradiography and ligand-dependent tyrosine kinase activity reveal insulin receptors and insulin-like growth factor I receptors in prepancreatic chicken embryos.

1989 • 52 citations

Molecular biology of the insulin-like growth factors

1990 • 51 citations

Characterization of Insulin-Like Growth Factor I Receptors in the Median Eminence of the Brain and Their Modulation by Food Restriction*

1988 • 50 citations

Effect of fatty acid composition on insulin and IGF-I binding in retinoblastoma cells.

1989 • 50 citations

Location of phosphotyrosine-containing proteins by immunocytochemistry in the rat forebrain corresponds to the distribution of the insulin receptor.

1990 • 48 citations

Bovine Chromaffin Cells Have Insulin‐Like Growth Factor‐I (IGF‐I) Receptors: IGF‐I Enhances Catecholamine Secretion

1988 • 46 citations

Insulin Receptors Mediate Growth Effects in Cultured Fetal Neurons. II. Activation of a Protein Kinase that Phosphorylates Ribosomal Protein S6*

1989 • 43 citations

Insulin-like growth factor I (IGF-I) receptors and IGF-I action in oligodendrocytes from rat brains

1991 • 43 citations

The Insulin Receptors of Chick Embryo Show Tissue- Specific Structural Differences which Parallel those of the Insulin-Like Growth Factor I Receptors*

1987 • 43 citations

Evidence for a subtype of insulin-like growth factor I receptor in brain

1986 • 42 citations

Molecular neurobiology 1988

1991 • 42 citations

Development of Receptors for Insulin and Insulin-Like Growth Factor-I in Head and Brain of Chick Embryos: Autoradiographic Localization*

1989 • 41 citations

Insulin-like growth factor 1 supports embryonic nerve cell survival

1990 • 39 citations

Developmental Regulation of Insulin-Like Growth Factor-I-Stimulated Glucose Transporter in Rat Brain Astrocytes*

1991 • 38 citations

Insulin promotes electrical coupling between cultured sympathetic neurons

1985 • 37 citations

Insulin and insulin-like growth factor 1 receptors during postnatal development of rat brain

1988 • 37 citations

Insulin-Like Growth Factor Receptors and Binding Protein in Rat Neuroblastoma Cells*

1989 • 37 citations

Ontogenesis of insulin receptors in human cerebral cortex

1991 • 36 citations

Insulin receptors in lizard brain and liver: structural and functional studies of ? and ? subunits demonstrate evolutionary conservation

1986 • 35 citations

Functional Insulin-Like Growth Factor I Receptors Are Expressed by Neural-Derived Continuous Cell Lines*

1988 • 33 citations

Receptor autoradiographic analysis of insulin-like growth factor-I (IGF-I) binding sites in rat forebrain and pituitary gland

1989 • 31 citations

Insulin-Like Growth Factor-I (IGF-I) Attenuation of Growth Hormone Is Enhanced by Overexpression of Pituitary IGF-I Receptors

1991 • 29 citations

Developmental Aspects of the Rat Brain Insulin Receptor: Loss of Sialic Acid and Fluctuation in Number Characterize Fetal Development*

1988 • 27 citations

Development of brain insulin receptors

1988 • 23 citations

The Insulin-Like Growth Factor-II (IGF II) Receptor from Rat Brain Is of Lower Apparent Molecular Weight than the IGF II Receptor from Rat Liver*

1987 • 20 citations

Centrally mediated hypoglycemic effect of insulin: apparent involvement of specific insulin receptors

1987 • 18 citations

Ontogenesis of the Insulin Receptor in the Rabbit Brain

1986 • 15 citations

The Heterogeneity of the Developing Brain Insulin Receptor

1988 • 14 citations

Characterization of an endogenous substrate related to insulin and insulin-like growth factor-I receptors in lizard brain.

1987 • 13 citations

Frog brain and liver show evolutionary conservation of tissue-specific differences among insulin receptors

1987 • 11 citations

Structural and functional studies on insulin receptors from alligator brain and liver

1987 • 8 citations

Physiologically Unique Insulin Receptors on Neuronal Cells

1987 • 7 citations

Glucose Transporters: Overview and Implications for the Brain

1987 • 2 citations