Insulin and insulin-like growth factors in the CNS

Insulin receptors are widely distributed in the central nervous system of the rat

1978 • 1,092 citations

Cellular Localization of Somatomedin (Insulin-Like Growth Factor) Messenger RNA in the Human Fetus

1987 • 663 citations

Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues.

1986 • 531 citations

Tissue Distribution of Insulin-Like Growth Factor I and II Messenger Ribonucleic Acid in the Adult Rat*

1987 • 418 citations

Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas

1986 • 416 citations

Blood-brain barrier transcytosis of insulin in developing rabbits

1987 • 348 citations

Insulin in the Brain

1987 • 340 citations

Developmental regulation of insulin-like growth factor II mRNA in different rat tissues.

1986 • 322 citations

Receptor-Mediated Peptide Transport through the Blood-Brain Barrier*

1986 • 309 citations

ADVANCES IN METABOLIC DISORDERS

1965 • 302 citations

Insulin in the Cerebrospinal Fluid

1967 • 283 citations

Insulin-like growth factors and insulin: comparative aspects

1985 • 262 citations

Insulin binds to specific receptors and stimulates 2-deoxy-D-glucose uptake in cultured glial cells from rat brain.

1984 • 255 citations

Cerebrospinal Fluid Insulin Levels Increase During Intravenous Insulin Infusions in Man*

1987 • 247 citations

Intraventricular insulin reduces food intake and body weight of lean but not obese zucker rats

1986 • 230 citations

Insulin-like growth factor I (IGF I) stimulates DNA synthesis in fetal rat brain cell cultures

1983 • 230 citations

Regional Concentrations of Insulin in the Rat Brain*

1983 • 216 citations

The Type II Insulin-Like Growth Factor (IGF) Receptor Has Low Affinity for IGF-I Analogs: Pleiotypic Actions of IGFs on Myoblasts Are Apparently Mediated by the Type I Receptor*

1987 • 204 citations

Characterization of Insulin-Like Growth Factor Receptors in Rat Anterior Pituitary, Hypothalamus, and Brain*

1984 • 199 citations

Ontogenesis of somatomedin and insulin receptors in the human fetus.

1983 • 197 citations

Rat insulin-like growth factor II gene

1986 • 192 citations

Insulin-like growth factor I receptors in neuronal and glial cells. Characterization and biological effects in primary culture.

1987 • 190 citations

The Na,K-ATPase of nervous tissue

1986 • 174 citations

Localization of 125I-insulin binding sites in the rat hypothalamus by quantitative autoradiography

1986 • 167 citations

Evidence for the presence of specific receptors for insulin-like growth factors 1 (IGF-1) and 2 (IGF-2) and insulin throughout the adult human brain

1982 • 166 citations

Identification of Somatomedin/Insulin-Like Growth Factor Immunoreactive Cells in the Human Fetus

1987 • 165 citations

Binding and Internalization of Insulin and Insulin-Like Growth Factors by Isolated Brain Microvessels

1986 • 165 citations

Two types of receptor for insulin-like growth factors in mammalian brain.

1985 • 163 citations

EVIDENCE FOR TWO SPECIES OF INSULIN-LIKE GROWTH FACTOR II (IGF II AND “BIG” IGF II) IN HUMAN SPINAL FLUID

1982 • 158 citations

Periventricular hypothalamic cells in the rat brain contain insulin mRNA

1986 • 143 citations

Genetically obese zucker rats have abnormally low brain insulin content

1985 • 140 citations

Characterization of a neuronal subtype of insulin-like growth factor I receptor.

1987 • 132 citations

Immunocytochemical Detection of Insulin in Rat Hypothalamus and Its Possible Uptake from Cerebrospinal Fluid^*

1983 • 121 citations

Quantitative receptor autoradiography

1987 • 117 citations

Characterization of somatomedin/insulin-like growth factor receptors and correlation with biologic action in cultured neonatal rat astroglial cells

1987 • 107 citations

Quantitative Autoradiographic Evidence for Insulin Receptors in the Choroid Plexus of the Rat Brain

1986 • 98 citations

Brain and Liver Insulin Binding Is Decreased in Zucker Rats Carrying the ’fa’ Gene*

1985 • 89 citations

The Failure of Rat Hypothalamic Tissues to Take up Labeled Insulin in Vivo or to Respond to Insulin in Vitro

1977 • 83 citations

Comparative measurements of glucose, beta-hydroxybutyrate, acetoacetate, and insulin in blood and cerebrospinal fluid during starvation

1974 • 76 citations

IMMUNOREACTIVE INSULIN LEVELS ARE ELEVATED IN THE CEREBROSPINAL FLUID OF GENETICALLY OBESE ZUCKER RATS

1983 • 75 citations

Identification of Binding Sites for an Insulin-like Growth Factor (IGF-1) in the Median Eminence of the Rat Brain by Quantitative Autoradiography

1986 • 69 citations

Evaluation of rat insulin messenger RNA in pancreatic and extrapancreatic tissues

1985 • 68 citations

Insulin receptors in rat brain cortex. Kinetic evidence for a receptor subtype in the central nervous system

1984 • 58 citations

An inexpensive microcomputer digital imaging system for densitometry: quantitative autoradiography of insulin receptors with 125I and LKB ultrofilm

1986 • 52 citations

Binding and internalization of insulin and insulin-like growth factors by isolated brain microvessels

1986 • 51 citations

Evidence for the role of insulin-like growth factor II (IGF-II) in the control of food intake

1987 • 51 citations

Polypeptide growth factors and the CNS

1986 • 47 citations

Proinsulin‐like material in mouse foetal brain cell cultures

1984 • 44 citations

Mediation of Insulin-Like Growth Factor Actions by the Insulin Receptor in H-35 Rat Hepatoma Cells*

1987 • 44 citations

The distribution of somatomedins in the nervous system of the cat and their release following neural stimulation

1982 • 42 citations

Evidence for a subtype of insulin-like growth factor I receptor in brain

1986 • 42 citations

CNS Regulation of Carbohydrate Metabolism

1983 • 41 citations

Quantitative autoradiographic evidence for insulin receptors in the choroid plexus of the rat brain

1986 • 37 citations

Partial Purification of a Hypothalamic Factor that Inhibits Gonadotropin-Releasing Hormone-Stimulated Luteinizing Hormone Release*

1987 • 31 citations

Origin of Insulin-Receptive Nerve Terminals in Rat Median Eminence*

1983 • 31 citations