Demonstration and structural comparison of receptors for insulin-like growth factor-I and -II (IGF-I and -II) in brain and blood-brain barrier

The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.

1962 • 2,522 citations

Insulin receptors are widely distributed in the central nervous system of the rat

1978 • 1,092 citations

Primary culture of parenchymal liver cells on collagen membranes

1975 • 808 citations

The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor.

1982 • 709 citations

Human Blood—Brain Barrier Insulin Receptor

1985 • 386 citations

Brain microvessel endothelial cells in tissue culture: A model for study of blood‐brain barrier permeability

1983 • 320 citations

Structural differences between insulin receptors in the brain and peripheral target tissues.

1983 • 265 citations

Insulin binds to specific receptors and stimulates 2-deoxy-D-glucose uptake in cultured glial cells from rat brain.

1984 • 255 citations

Characterization of an in vitro blood-brain barrier model system for studying drug transport and metabolism.

1986 • 246 citations

Characterization of Insulin-Like Growth Factor Receptors in Rat Anterior Pituitary, Hypothalamus, and Brain*

1984 • 199 citations

Evidence for the presence of specific receptors for insulin-like growth factors 1 (IGF-1) and 2 (IGF-2) and insulin throughout the adult human brain

1982 • 166 citations

Binding and Internalization of Insulin and Insulin-Like Growth Factors by Isolated Brain Microvessels

1986 • 165 citations

Two types of receptor for insulin-like growth factors in mammalian brain.

1985 • 163 citations

EVIDENCE FOR TWO SPECIES OF INSULIN-LIKE GROWTH FACTOR II (IGF II AND “BIG” IGF II) IN HUMAN SPINAL FLUID

1982 • 158 citations

Characterization of a neuronal subtype of insulin-like growth factor I receptor.

1987 • 132 citations

Production of insulin‐like growth factors and their carrier by rat pituitary gland and brain explants in culture

1981 • 132 citations

Development of Brain Insulin Receptors: Structural and Functional Studies of Insulin Receptors from Whole Brain and Primary Cell Cultures*

1986 • 116 citations

Ontogeny of Receptors for Insulin-Like Peptides in Chick Embryo Tissues: Early Dominance of Insulin-Like Growth Factor over Insulin Receptors in Brain*

1985 • 116 citations

Characterization of insulin receptor subunits in brain and other tissues by photoaffinity labeling

1980 • 114 citations

Characterization of somatomedin/insulin-like growth factor receptors and correlation with biologic action in cultured neonatal rat astroglial cells

1987 • 107 citations

Unique Features of the Insulin Receptor in Rat Brain

1984 • 96 citations

Oligosaccharide Heterogeneity of Insulin Receptors. Comparison of N-Linked Glycosylation of Insulin Receptors in Adipocytes and Brain*

1986 • 90 citations

Purification and characterization of the human brain insulin receptor.

1986 • 76 citations

Identification of Binding Sites for an Insulin-like Growth Factor (IGF-1) in the Median Eminence of the Rat Brain by Quantitative Autoradiography

1986 • 69 citations

Blood–Brain Barrier Protein and Phosphorylation and Dephosphorylation

1985 • 62 citations

Somatomedin levels in cerebrospinal fluid from adults with pituitary disorders

1984 • 58 citations

Evidence for a subtype of insulin-like growth factor I receptor in brain

1986 • 42 citations

Purification of the Insulin-like growth factor II (IGF-II) receptor from an IGF-II-producing cell line, and generation of an antibody which both immunoprecipitates and blocks the type 2 IGF receptor

1986 • 40 citations

Identification and characterization of insulin receptors on foetal-mouse brain-cortical cells

1984 • 38 citations

Receptors for insulin-like growth factors and insulin on murine fetal cortical brain cells

1986 • 21 citations