Insulin receptors and insulin action in dissociated brain cells

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor

1982 • 1,138 citations

Insulin receptors are widely distributed in the central nervous system of the rat

1978 • 1,092 citations

Growth and cultivation of dissociated neurons and glial cells from embryonic chick, rat and human brain in flask cultures.

1972 • 760 citations

Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system

1982 • 680 citations

Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine.

1982 • 441 citations

Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta.

1982 • 287 citations

Binding of insulin receptors to lectins: evidence for common carbohydrate determinants on several membrane receptors

1981 • 267 citations

Structural differences between insulin receptors in the brain and peripheral target tissues.

1983 • 265 citations

Insulin binds to specific receptors and stimulates 2-deoxy-D-glucose uptake in cultured glial cells from rat brain.

1984 • 255 citations

Characterization of insulin-mediated phosphorylation of the insulin receptor in a cell-free system.

1983 • 223 citations

Insulin receptors: binding kinetics and structure-function relationship of insulin

1984 • 200 citations

Insulin receptors and insulin modulation of norepinephrine uptake in neuronal cultures from rat brain.

1985 • 195 citations

Purification of the insulin receptor from human placenta by chromatography on immobilized wheat germ lectin and receptor antibody.

1980 • 187 citations

Effect of insulin on central catecholamines

1983 • 186 citations

Insulin inhibits pyramidal neurons in hippocampal slices

1984 • 176 citations

Glucose Suppresses Basal Firing and Haloperidol-Induced Increases in the Firing Rate of Central Dopaminergic Neurons

1980 • 147 citations

Development of Brain Insulin Receptors: Structural and Functional Studies of Insulin Receptors from Whole Brain and Primary Cell Cultures*

1986 • 116 citations

Characterization of insulin receptor subunits in brain and other tissues by photoaffinity labeling

1980 • 114 citations

Binding of [125]insulin to specific receptors and stimulation of nucleotide incorporation in cells cultured from rat brain

1980 • 111 citations

The insulin receptor of rat brain is coupled to tyrosine kinase activity.

1984 • 106 citations

Insulin receptor phosphorylation in intact adipocytes and in a cell-free system

1982 • 101 citations

Unique Features of the Insulin Receptor in Rat Brain

1984 • 96 citations

Effect of Cerebral Intraventricular Insulin on Pancreatic Insulin Secretion in the Dog

1975 • 79 citations

Two different protein kinase activities are associated with the insulin receptor

1983 • 77 citations

Effects of insulin and tunicamycin on neuronal insulin receptors in culture

1983 • 66 citations

Studies on the Nature and Mode of Action of the Insulin-sensitive Glucoregulator Receptor in the Central Nervous System

1975 • 51 citations

Decrease in plasma glucose concentration after microinjection of insulin into VMN

1981 • 47 citations

Adult-level insulin binding is present in term fetal rat CNS membranes

1982 • 45 citations

Binding of Insulin by Monkey and Pig Hypothalamus

1983 • 37 citations

Transport of 2-deoxy-d-glucose by dissociated brain cells

1985 • 35 citations

Insulin receptors in lizard brain and liver: structural and functional studies of ? and ? subunits demonstrate evolutionary conservation

1986 • 35 citations

Is insulin a neuromodulator?

1982 • 26 citations

Internalization of the neonatal brain insulin receptor

1985 • 4 citations