External mechanical strain regulates membrane targeting of Rho GTPases by controlling microtubule assembly

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Mechanotransduction Across the Cell Surface and Through the Cytoskeleton

1993 • 2,947 citations

Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates

2001 • 2,089 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1999 • 1,558 citations

TENSEGRITY: THE ARCHITECTURAL BASIS OF CELLULAR MECHANOTRANSDUCTION

1997 • 1,550 citations

Focal Contacts as Mechanosensors

2001 • 1,390 citations

Cellular tensegrity: defining new rules of biological design that govern the cytoskeleton

1993 • 1,124 citations

Mechanotransduction and the functional response of bone to mechanical strain

1995 • 1,008 citations

Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton

1997 • 802 citations

The structural and mechanical complexity of cell-growth control

1999 • 769 citations

Bidirectional signaling between the cytoskeleton and integrins

1999 • 765 citations

Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases

1999 • 765 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton

2002 • 633 citations

Integrin-mediated Signals Regulated by Members of the Rho Family of GTPases

1998 • 615 citations

mDia mediates Rho-regulated formation and orientation of stable microtubules

2001 • 566 citations

Mechanotransduction in Response to Shear Stress

1999 • 560 citations

Assembly and mechanosensory function of focal contacts

2001 • 548 citations

Cellular control lies in the balance of forces

1998 • 530 citations

Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts

1999 • 491 citations

Cyclic mechanical strain regulates the development of engineered smooth muscle tissue

1999 • 489 citations

Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK

2000 • 454 citations

Microtubule Targeting of Substrate Contacts Promotes Their Relaxation and Dissociation

1999 • 452 citations

Cell motility: can Rho GTPases and microtubules point the way?

2001 • 447 citations

Regulation of extracellular matrix gene expression by mechanical stress

1999 • 425 citations

Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands

2001 • 398 citations

Mechanotransduction and functional response of the skeleton to physical stress: The mechanisms and mechanics of bone adaptation*

1998 • 380 citations

Mechanoreception at the cellular level: the detection, interpretation, and diversity of responses to mechanical signals

1995 • 375 citations

Mechanical strain induces growth of vascular smooth muscle cells via autocrine action of PDGF.

1993 • 368 citations

Role of integrins in cellular responses to mechanical stress and adhesion

1997 • 335 citations

Extracellular signal-regulated kinase and c-Jun NH2-terminal kinase activation by mechanical stretch is integrin-dependent and matrix-specific in rat cardiac fibroblasts.

1998 • 330 citations

Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI

2002 • 326 citations

Targeting, Capture, and Stabilization of Microtubules at Early Focal Adhesions

1998 • 323 citations

Collagen expression in mechanically stimulated cardiac fibroblasts.

1991 • 311 citations

Mechanical strain of rat vascular smooth muscle cells is sensed by specific extracellular matrix/integrin interactions.

1995 • 307 citations

Fibroblast contractility and actin organization are stimulated by microtubule inhibitors

1989 • 303 citations

Force transduction by Triton cytoskeletons

2002 • 289 citations

Rho Guanosine Triphosphatase Mediates the Selective Stabilization of Microtubules Induced by Lysophosphatidic Acid

1998 • 257 citations

Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins.

1994 • 245 citations

Effects of cell tension on the small GTPase Rac

2002 • 237 citations

Contraction due to microtubule disruption is associated with increased phosphorylation of myosin regulatory light chain.

1995 • 229 citations

Angiotensin II Activates RhoA in Cardiac Myocytes

1998 • 224 citations

Mechanical influences on vascular smooth muscle cell function

1998 • 216 citations

Mechanical Stressing of Integrin Receptors Induces Enhanced Tyrosine Phosphorylation of Cytoskeletally Anchored Proteins

1998 • 216 citations

Microtubule Disruption Induces the Formation of Actin Stress Fibers and Focal Adhesions in Cultured Cells: Possible Involvement of the Rho Signal Cascade.

1996 • 214 citations

Mechanotransduction of Rat Aortic Vascular Smooth Muscle Cells Requires RhoA and Intact Actin Filaments

1999 • 203 citations

Mechanotransduction by Vascular Smooth Muscle

1995 • 203 citations

Microtubule Depolymerization Induces Stress Fibers, Focal Adhesions, and DNA Synthesis via the GTP-Binding Protein Rho

1998 • 197 citations

Rho Family Small G Proteins Play Critical Roles in Mechanical Stress–Induced Hypertrophic Responses in Cardiac Myocytes

1999 • 186 citations

Differential Translocation of Rho Family GTPases by Lysophosphatidic Acid, Endothelin-1, and Platelet-derived Growth Factor

1996 • 151 citations

Development and characterization of a cloned rat pulmonary arterial smooth muscle cell line that maintains differentiated properties through multiple subcultures.

1992 • 146 citations

Autoregulation of tubulin synthesis in hepatocytes and fibroblasts.

1985 • 136 citations

Mechanically Strained Cells of the Osteoblast Lineage Organize Their Extracellular Matrix Through Unique Sites of αVβ3-Integrin Expression

2000 • 131 citations

Tensile stress stimulates microtubule outgrowth in living cells

2002 • 127 citations

Requirement for Rho in Integrin Signalling

1997 • 127 citations

Strain Reorganizes Focal Adhesions and Cytoskeleton in Cultured Airway Smooth Muscle Cells

1997 • 97 citations

Control of microtubule assembly by extracellular matrix and externally applied strain

2001 • 91 citations

A thermodynamic model for force integration and microtubule assembly during axonal elongation

1988 • 80 citations

Microtubule assembly is regulated by externally applied strain in cultured smooth muscle cells

1998 • 78 citations

Mechanical Load and Polypeptide Growth Factors Stimulate Cardiac Fibroblast Activity

1995 • 67 citations

Mechanical Strain Increases Protein Tyrosine Phosphorylation in Airway Smooth Muscle Cells

1998 • 64 citations

Extracellular matrix controls tubulin monomer levels in hepatocytes by regulating protein turnover.

1994 • 54 citations

Quantification of Fibronectin Adsorption to Silicone-Rubber Cell Culture Substrates

2002 • 31 citations

Chapter 8 A Quantitative Solid-Phase Binding Assay for Tubulin

1993 • 9 citations