Mechanical Strain Increases Protein Tyrosine Phosphorylation in Airway Smooth Muscle Cells

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

Tyrosine Kinase Inhibition: An Approach to Drug Development

1995 • 1,655 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

Integrin-mediated cell adhesion activates mitogen-activated protein kinases.

1994 • 660 citations

Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.

1994 • 525 citations

Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase.

1994 • 469 citations

Novel tyrosine kinase substrates from Rous sarcoma virus-transformed cells are present in the membrane skeleton.

1989 • 457 citations

Morphometric Analysis of the Lung in Bronchopulmonary Dysplasia

1991 • 361 citations

Quantitative studies of endothelial cell adhesion. Directional remodeling of focal adhesion sites in response to flow forces.

1994 • 322 citations

Mechanical strain of rat vascular smooth muscle cells is sensed by specific extracellular matrix/integrin interactions.

1995 • 307 citations

Adhesive ligand binding to integrin alpha IIb beta 3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAK

1993 • 192 citations

Paxillin: A cytoskeletal target for tyrosine kinases

1994 • 162 citations

Localization of paxillin, a focal adhesion protein, to smooth muscle dense plaques, and the myotendinous and neuromuscular junctions of skeletal muscle

1991 • 100 citations

Acute lung injury. Pathogenesis of intraalveolar fibrosis.

1991 • 98 citations

Strain Reorganizes Focal Adhesions and Cytoskeleton in Cultured Airway Smooth Muscle Cells

1997 • 97 citations

Strain increases airway smooth muscle cell proliferation.

1994 • 92 citations

Phosphorylation of dense-plaque proteins talin and paxillin during tracheal smooth muscle contraction

1995 • 82 citations

Changes in Calibre of the Smaller Airways in Man

1963 • 39 citations

PP125FAK Tyrosine kinase activity is not required for the assembly of f-actin stress fibres and focal adhesions in cultured mouse aortic smooth muscle cells

1995 • 37 citations

Thyroid Cell Spreading and Focal Adhesion Formation Depend upon Protein Tyrosine Phosphorylation and Actin Microfilaments

1994 • 26 citations

In vivo estimation of tracheal distensibility and hysteresis in normal adults

1987 • 23 citations