TENSEGRITY: THE ARCHITECTURAL BASIS OF CELLULAR MECHANOTRANSDUCTION

Biomechanics. Mechanical Properties of Living Tissues

1982 • 6,144 citations

Mechanotransduction Across the Cell Surface and Through the Cytoskeleton

1993 • 2,947 citations

Flow-mediated endothelial mechanotransduction

1995 • 2,728 citations

Biomechanics: Mechanical Properties of Living Tissues

1981 • 2,617 citations

Integrins and other cell adhesion molecules

1990 • 1,990 citations

Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure

1997 • 1,572 citations

Engineering Cell Shape and Function

1994 • 1,447 citations

Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro

1993 • 1,347 citations

Beyond self-assembly: From microtubules to morphogenesis

1986 • 1,334 citations

Silicone Rubber Substrata: A New Wrinkle in the Study of Cell Locomotion

1980 • 1,333 citations

Cellular tensegrity: defining new rules of biological design that govern the cytoskeleton

1993 • 1,124 citations

Mechanotransduction and the functional response of bone to mechanical strain

1995 • 1,008 citations

Synergistic Roles for Receptor Occupancy and Aggregation in Integrin Transmembrane Function

1995 • 900 citations

Receptors; models for binding, trafficking and signaling

1997 • 883 citations

Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix.

1989 • 877 citations

Lifetime of the P-selectin-carbohydrate bond and its response to tensile force in hydrodynamic flow

1995 • 705 citations

Integrins as mechanochemical transducers

1991 • 684 citations

Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element.

1993 • 638 citations

The Architecture of Life

1998 • 545 citations

Control of cytoskeletal mechanics by extracellular matrix, cell shape, and mechanical tension

1994 • 528 citations

Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex.

1995 • 503 citations

Mechanism of endothelial cell shape change and cytoskeletal remodeling in response to fluid shear stress

1996 • 503 citations

How does extracellular matrix control capillary morphogenesis?

1989 • 466 citations

Isometric contraction by fibroblasts and endothelial cells in tissue culture: a quantitative study

1992 • 456 citations

Cellular Tensegrity: Exploring How Mechanical Changes in the Cytoskeleton Regulate Cell Growth, Migration, and Tissue Pattern during Morphogenesis

1994 • 428 citations

Receptors

1993 • 391 citations

Integrin α2β1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells

1991 • 379 citations

Cell shape, cytoskeletal mechanics, and cell cycle control in angiogenesis

1995 • 339 citations

Integrin-cytoskeletal interactions in migrating fibroblasts are dynamic, asymmetric, and regulated.

1993 • 336 citations

Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown.

1993 • 335 citations

Quantitative studies of endothelial cell adhesion. Directional remodeling of focal adhesion sites in response to flow forces.

1994 • 322 citations

Two types of mechanosensitive channels in the Escherichia coli cell envelope: solubilization and functional reconstitution

1993 • 321 citations

Free energy transduction in polypeptides and proteins based on inverse temperature transitions

1992 • 309 citations

Mechanical strain of rat vascular smooth muscle cells is sensed by specific extracellular matrix/integrin interactions.

1995 • 307 citations

Tension and compression in the cytoskeleton of PC-12 neurites. II: Quantitative measurements.

1988 • 288 citations

Altering the cellular mechanical force balance results in integrated changes in cell, cytoskeletal and nuclear shape

1992 • 274 citations

Vinculin Promotes Cell Spreading by Mechanically Coupling Integrins to the Cytoskeleton

1997 • 267 citations

Mechanosensory calcium‐selective cation channels in epidermal cells

1993 • 252 citations

Roles of mechano-sensitive ion channels, cytoskeleton, and contractile activity in stretch-induced immediate-early gene expression and hypertrophy of cardiac myocytes.

1992 • 249 citations

Role of G proteins in shear stress-mediated nitric oxide production by endothelial cells

1994 • 248 citations

Probing transmembrane mechanical coupling and cytomechanics using magnetic twisting cytometry

1995 • 236 citations

Cytoskeletal filament assembly and the control of cell spreading and function by extracellular matrix

1995 • 234 citations

Endothelial growth factors and extracellular matrix regulate DNA synthesis through modulation of cell and nuclear expansion

1987 • 225 citations

Tension and compression in the cytoskeleton of PC 12 neurites.

1985 • 224 citations

The riddle of morphogenesis: A question of solution chemistry or molecular cell engineering?

1993 • 219 citations

A Microstructural Approach to Cytoskeletal Mechanics based on Tensegrity

1996 • 218 citations

Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin cytoskeleton.

1996 • 212 citations

A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans

1994 • 204 citations

Proteins associated with with cytoplasmic surface of adhesion molecules

1993 • 204 citations

Mechanotransduction

1992 • 179 citations

Single mRNAs visualized by ultrastructural in situ hybridization are principally localized at actin filament intersections in fibroblasts.

1994 • 173 citations

Rapid adaptation of single mechanosensitive channels in Xenopus oocytes.

1992 • 154 citations

Mechanical continuity and reversible chromosome disassembly within intact genomes removed from living cells

1997 • 152 citations

The contribution of the extracellular matrix to gravisensing in characean cells

1992 • 150 citations

Microfilament or microtubule assembly or disassembly against a force.

1981 • 137 citations

Cell structure and DNA organization.

1991 • 133 citations

Integrins and Modulation of Transmitter Release from Motor Nerve Terminals by Stretch

1995 • 128 citations

Extension of filopodia by motor‐dependent actin assembly

1992 • 127 citations

Extracellular Proteins Needed for C. elegans Mechanosensation

1996 • 122 citations

Basement membrane as a spatial organizer of polarized epithelia. Exogenous basement membrane reorients pancreatic epithelial tumor cells in vitro.

1986 • 118 citations

Mechanotransduction in vertebrate hair cells: structure and function of the stereociliary bundle

1995 • 114 citations

Mechanical stimulation of skeletal muscle increases prostaglandin F_2α production, cyclooxygenase activity, and cell growth by a pertussis toxin sensitive mechanism

1995 • 108 citations

Regulation of Nuclear Transport in Proliferating and Quiescent Cells

1993 • 107 citations

Flow-related responses of intracellular inositol phosphate levels in cultured aortic endothelial cells.

1993 • 107 citations

Chimeric G alpha s/G alpha i2 proteins define domains on G alpha s that interact with tubulin for beta-adrenergic activation of adenylyl cyclase.

1994 • 80 citations

A thermodynamic model for force integration and microtubule assembly during axonal elongation

1988 • 80 citations

Association of intermediate filaments with vinculin‐containing adhesion plaques of fibroblasts

1987 • 78 citations

Cellular harmonic information transfer through a tissue tensegrity-matrix system

1991 • 78 citations

Stress relaxation of fibroblasts activates a cyclic AMP signaling pathway.

1994 • 75 citations

Elongation of Confluent Endothelial Cells in Culture: The Importance of Fields of Force in the Associated Alterations of Their Cytoskeletal Structure

1995 • 73 citations

Structure and function of titin and nebulin

1995 • 67 citations

Extracellular matrix allows PC12 neurite elongation in the absence of microtubules.

1990 • 60 citations

Disruption of microtubule network in human monocytes induces expression of interleukin-1 but not that of interleukin-6 nor tumor necrosis factor-alpha. Involvement of protein kinase A stimulation

1993 • 59 citations

Receptors for N-acetylated sugars may stimulate adenylate cyclase to sensitize and tune mechanoreceptors involved in triggering nematocyst discharge

1992 • 55 citations

Extracellular matrix controls tubulin monomer levels in hepatocytes by regulating protein turnover.

1994 • 54 citations

Stretching Mesangial Cells Stimulates Tyrosine Phosphorylation of Focal Adhesion Kinase pp125FAK

1995 • 51 citations

Direct Binding of F Actin to the Cytoplasmic Domain of the α2 Integrin Chain in Vitro

1995 • 49 citations

Rab and rho GTPases are involved in specific response of periodontal ligament fibroblasts to mechanical stretching

1995 • 42 citations

Integrin-Dependent Control of Inositol Lipid Synthesis in Vascular Endothelial Cells and Smooth Muscle Cells

1996 • 39 citations

High-pressure freeze fixation reveals novel features during ontogenesis of the vegetative cell inLedebouriapollen: an ultrastructural and cytochemical study

1995 • 26 citations