Cytosolic Free Calcium and the Cytoskeleton in the Control of Leukocyte Chemotaxis

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Adhesion receptors of the immune system

1990 • 6,585 citations

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Cell Migration: A Physically Integrated Molecular Process

1996 • 3,909 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Human Chemokines: An Update

1997 • 2,235 citations

FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING

1996 • 1,900 citations

Kinesin and Dynein Superfamily Proteins and the Mechanism of Organelle Transport

1998 • 1,634 citations

Capacitative calcium entry revisited

1990 • 1,499 citations

Store depletion and calcium influx

1997 • 1,422 citations

Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness

1997 • 1,400 citations

The Molecular Biology of Leukocyte Chemoattractant Receptors

1994 • 1,224 citations

Range of Messenger Action of Calcium Ion and Inositol 1,4,5-Trisphosphate

1992 • 1,144 citations

Capacitative calcium entry

1995 • 1,112 citations

A Structural Scaffolding of Intermediate Filaments in Health and Disease

1998 • 1,003 citations

Protein kinase C

1991 • 914 citations

Ability of polymorphonuclear leukocytes to orient in gradients of chemotactic factors.

1977 • 905 citations

Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx

1993 • 892 citations

Nucleation of microtubule assembly by a γ-tubulin-containing ring complex

1995 • 851 citations

Small GTP-Binding Proteins and the Regulation of the Actin Cytoskeleton

1994 • 822 citations

Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton

1997 • 802 citations

MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium–calmodulin

1992 • 728 citations

Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils.

1996 • 719 citations

Sphingolipid metabolism and cell growth regulation

1996 • 709 citations

Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ

1997 • 671 citations

Unconventional Myosins in Cell Movement, Membrane Traffic, and Signal Transduction

1998 • 649 citations

Ca2+- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils

1995 • 555 citations

Microtubule nucleation by γ-tubulin-containing rings in the centrosome

1995 • 530 citations

Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate

1996 • 522 citations

Pericentrin and γ-Tubulin Form a Protein Complex and Are Organized into a Novel Lattice at the Centrosome

1998 • 485 citations

A Specific Product of Phosphatidylinositol 3-Kinase Directly Activates the Protein Kinase Akt through Its Pleckstrin Homology Domain

1997 • 481 citations

Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody.

1997 • 474 citations

Microtubules and microtubule-associated proteins

1995 • 465 citations

Molecular Cloning and Functional Characterization of a Novel Human CC Chemokine Receptor (CCR5) for RANTES, MIP-1β, and MIP-1α

1996 • 454 citations

Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration

1997 • 438 citations

Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages

1997 • 415 citations

Phospholipase D: enzymology, mechanisms of regulation, and function

1997 • 405 citations

Molecular Cloning of a Novel Human CC Chemokine EBI1-ligand Chemokine That Is a Specific Functional Ligand for EBI1, CCR7

1997 • 405 citations

Human recombinant monocyte chemotactic protein and other c-c chemokines bind and induce directional migration of dendritic cells in vitro

1996 • 373 citations

Interaction of Chemokine Receptor CCR5 with its Ligands: Multiple Domains for HIV-1 gp120 Binding and a Single Domain for Chemokine Binding

1997 • 363 citations

Golgi Vesiculation and Lysosome Dispersion in Cells Lacking Cytoplasmic Dynein

1998 • 363 citations

Regulation of Phosphoinositide Phospholipases by Hormones, Neurotransmitters, and Other Agonists Linked to G Proteins

1996 • 362 citations

Most of centrin in animal cells is not centrosome-associated and centrosomal centrin is confined to the distal lumen of centrioles

1996 • 351 citations

LFA-1–mediated Adhesion Is Regulated by Cytoskeletal Restraint and by a Ca2+-dependent Protease, Calpain

1998 • 324 citations

Regulation of the ERK Subgroup of MAP Kinase Cascades Through G Protein-Coupled Receptors

1997 • 323 citations

Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases

1997 • 314 citations

The Directed Migration of Eukaryotic Cells

1986 • 312 citations

Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP.

1997 • 311 citations

Signal transduction and actin filament organization

1996 • 309 citations

Cell adhesion and angiogenesis.

1997 • 299 citations

Tubulin Post‐Translational Modifications

1997 • 289 citations

Calcium Gradients Underlying Polarization and Chemotaxis of Eosinophils

1991 • 283 citations

T lymphocyte recruitment by interleukin-8 (IL-8). IL-8-induced degranulation of neutrophils releases potent chemoattractants for human T lymphocytes both in vitro and in vivo.

1996 • 271 citations

Rho: a connection between membrane receptor signalling and the cytoskeleton

1996 • 271 citations

Transient increases in cytosolic free calcium appear to be required for the migration of adherent human neutrophils [published erratum appears in J Cell Biol 1990 Mar;110(3):861]

1990 • 265 citations

Biology of chemokine and classical chemoattractant receptors: differential requirements for adhesion-triggering versus chemotactic responses in lymphoid cells.

1996 • 265 citations

Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction.

1995 • 264 citations

MOLECULAR GENETICS OF SIGNAL TRANSDUCTION IN DICTYOSTELIUM

1996 • 261 citations

Microfilament dynamics during cell movement and chemotaxis monitored using a GFP–actin fusion protein

1997 • 261 citations

C3a and C5a are chemotaxins for human mast cells and act through distinct receptors via a pertussis toxin-sensitive signal transduction pathway.

1996 • 250 citations

Myosin light chain kinases.

1997 • 247 citations

Cellular phosphorylation of tau by GSK-3β influences tau binding to microtubules and microtubule organisation

1996 • 242 citations

Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide.

1996 • 240 citations

The role of neutrophils and platelet-activating factor in mediating experimental pancreatitis

1996 • 236 citations

Blood, Pure and Eloquent

1980 • 233 citations

Chemokines induce migrational responses in human breast carcinoma cell lines

1997 • 222 citations

Sequential regulation of alpha 4 beta 1 and alpha 5 beta 1 integrin avidity by CC chemokines in monocytes: implications for transendothelial chemotaxis.

1996 • 220 citations

Mitogen-Activated Protein Kinase Activation Is Involved in Platelet-Derived Growth Factor-Directed Migration by Vascular Smooth Muscle Cells

1997 • 219 citations

Capacitative Ca2+ Entry Is Closely Linked to the Filling State of Internal Ca2+ Stores: A Study Using Simultaneous Measurements of ICRAC and Intraluminal [Ca2+]

1998 • 213 citations

Regulation of the Inositol 1,4,5-Trisphosphate Receptor by Tyrosine Phosphorylation

1996 • 212 citations

Evidence for MEK-independent pathways regulating the prolonged activation of the ERK-MAP kinases

1997 • 202 citations

Cathepsin L proteinase secreted by Fasciola hepatica in vitro prevents antibody-mediated eosinophil attachment to newly excysted juveniles

1993 • 194 citations

Chemotactic Peptide N-formyl-Met-Leu-Phe Activation of p38 Mitogen-activated Protein Kinase (MAPK) and MAPK-activated Protein Kinase-2 in Human Neutrophils

1997 • 184 citations

Neutrophil production of IL-12 and IL-10 in candidiasis and efficacy of IL-12 therapy in neutropenic mice.

1997 • 183 citations

The role of chemokines in inflammation

1996 • 182 citations

Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice.

1996 • 180 citations

Patterns of elevated free calcium and calmodulin activation in living cells

1992 • 177 citations

A novel type of myosin implicated in signalling by rho family GTPases.

1995 • 176 citations

Integrin dynamics on the tail region of migrating fibroblasts

1996 • 175 citations

Human eotaxin represents a potent activator of the respiratory burst of human eosinophils

1996 • 171 citations

Neutrophil motility in extracellular matrix gels: mesh size and adhesion affect speed of migration

1997 • 170 citations

FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase.

1994 • 167 citations

Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils

1997 • 163 citations

The role of the cortical cytoskeleton: F-actin crosslinking proteins protect against osmotic stress, ensure cell size, cell shape and motility, and contribute to phagocytosis and development

1996 • 161 citations

Integrin‐mediated calcium signaling and regulation of cell adhesion by intracellular calcium

1997 • 159 citations

Cell Signalling Through Guanine‐Nucleotide‐Binding Regulatory Proteins (G Proteins) and Phospholipases

1997 • 157 citations

A role for gelsolin in actuating epidermal growth factor receptor-mediated cell motility.

1996 • 155 citations

Lymphocyte Activation in Health and Disease

1997 • 148 citations

Isolation of mitotic apparatus containing vesicles with calcium sequestration activity

1980 • 148 citations

Eotaxin Triggers Eosmophil-Selective Chemotaxis and Calcium Flux via a Distinct Receptor and Induces Pulmonary Eosinophilia in the Presence of Interleukin 5 in Mice

1996 • 146 citations

Centrosome positioning and directionality of cell movements

1997 • 145 citations

The pool of map kinase associated with microtubules is small but constitutively active.

1996 • 142 citations

A novel member of the rho family of small GTP-binding proteins is specifically required for cytokinesis.

1996 • 140 citations

Ca2+ Signaling and Intracellular Ca2+ Binding Proteins

1996 • 138 citations

Redistribution of intracellular Ca2+ stores during phagocytosis in human neutrophils

1994 • 136 citations

The Lipid Products of Phosphoinositide 3-Kinase Increase Cell Motility through Protein Kinase C

1997 • 133 citations

Regulation of Microtubule Dynamics by Ca²⁺/Calmodulin-Dependent Kinase IV/Gr-Dependent Phosphorylation of Oncoprotein 18

1997 • 132 citations

Tyrosine phosphorylation and activation of a new mitogen-activated protein (MAP)-kinase cascade in human neutrophils stimulated with various agonists

1996 • 131 citations

The composition and dynamics of cell-substratum adhesions in locomoting fish keratocytes

1997 • 130 citations

Mapping of the C5a receptor signal transduction network in human neutrophils.

1994 • 124 citations

Dynamic imaging of neutrophil migration in three dimensions: mechanical interactions between cells and matrix

1997 • 124 citations

HIV-1-Tat protein promotes chemotaxis and invasive behavior by monocytes.

1996 • 122 citations

Ecological Controls on the Evolutionary Recovery of Post-Paleozoic Crinoids

1996 • 120 citations

Recent quantitative studies of actin filament turnover during cell locomotion

1993 • 119 citations

A Tyrosine Kinase Signaling Pathway Accounts for the Majority of Phosphatidylinositol 3,4,5-Trisphosphate Formation in Chemoattractant-stimulated Human Neutrophils

1996 • 115 citations

Crosstalk between cell adhesion molecules: vinculin as a paradigm for regulation by conformation

1996 • 113 citations

Regulation of calmodulin-binding myosins

1995 • 113 citations

Attachment to fibronectin or vitronectin makes human neutrophil migration sensitive to alterations in cytosolic free calcium concentration.

1991 • 113 citations

Discrete Steps in Binding and Signaling of Interleukin-8 with Its Receptor

1996 • 106 citations

Platelet-activating factor induces tyrosine phosphorylation in human neutrophils.

1991 • 106 citations

Centrosome-microtubule nucleation

1997 • 100 citations

Polymorphonuclear leukocyte adherence induces actin polymerization by a transduction pathway which differs from that used by chemoattractants.

1989 • 98 citations

MCP-1-mediated chemotaxis requires activation of non-overlapping signal transduction pathways

1997 • 98 citations

Substrate Recognition by Osteoclast Precursors Induces C-src/Microtubule Association

1997 • 97 citations

CLIPs for organellemicrotubule interactions

1996 • 96 citations

Local and global changes in cytosolic free calcium in neutrophils during chemotaxis and phagocytosis

1990 • 95 citations

The Rho-GEF Rom2p Localizes to Sites of Polarized Cell Growth and Participates in Cytoskeletal Functions inSaccharomyces cerevisiae

1997 • 95 citations

The Small GTP-binding Protein Rac Promotes the Dissociation of Gelsolin from Actin Filaments in Neutrophils

1998 • 94 citations

Microtubule-associated Proteins Regulate Microtubule Function as the Track for Intracellular Membrane Organelle Transports.

1996 • 94 citations

Focal adhesion as a signal transduction organelle

1994 • 93 citations

Identification and regulation of protein kinase C-delta in human neutrophils.

1996 • 91 citations

Gelsolin Modulates Phospholipase C Activity In Vivo through Phospholipid Binding

1997 • 90 citations

The actin-related proteins

1996 • 90 citations

Activation of MEKK by Formyl-methionyl-leucyl-phenylalanine in Human Neutrophils

1996 • 88 citations

Contrasting responses to multiple chemotactic stimuli in transendothelial migration: heterologous desensitization in neutrophils and augmentation of migration in eosinophils.

1997 • 87 citations

Analysis of cell movement during the culmination phase of Dictyostelium development

1996 • 86 citations

Fibrin regulates neutrophil migration in response to interleukin 8, leukotriene B4, tumor necrosis factor, and formyl-methionyl-leucyl-phenylalanine.

1995 • 85 citations

Dependence of Fibroblast Migration on Actin Severing Activity of Gelsolin

1996 • 85 citations

Production of Leukotriene C4 in Different Human Tissues Is Attributable to Distinct Membrane Bound Biosynthetic Enzymes

1997 • 85 citations

Phosphorylation of theDictyostelium myosin II heavy chain is necessary for maintaining cellular polarity and suppressing turning during chemotaxis

1998 • 84 citations

A crucial role for beta 2 integrin in the activation of eosinophils stimulated by IgG.

1995 • 84 citations

Cytoplasmic microtubules in polymorphonuclear leukocytes: Effects of chemotactic stimulation and colchicine

1982 • 84 citations

Microtubule-associated Protein-dependent Binding of Phagosomes to Microtubules

1996 • 84 citations

5-Oxo-eicosanoids and Hematopoietic Cytokines Cooperate in Stimulating Neutrophil Function and the Mitogen-activated Protein Kinase Pathway

1996 • 83 citations

ADictyostelium myosin I plays a crucial role in regulating the frequency of pseudopods formed on the substratum

1996 • 81 citations

Gelsolin-actin interaction and actin polymerization in human neutrophils.

1990 • 81 citations

Profilin and Gelsolin Stimulate Phosphatidylinositol 3-Kinase Activity

1996 • 80 citations

5-Oxo-eicosatetraenoate is a broadly active, eosinophil-selective stimulus for human granulocytes.

1996 • 79 citations

Intracellular calcium levels correlate with speed and persistent forward motion in migrating neutrophils

1995 • 79 citations

Cell-to-cell and cell-to-matrix interactions mediate chemokine expression: an important component of the inflammatory lesion

1997 • 78 citations

Ceramide regulates oxidant release in adherent human neutrophils

1994 • 77 citations

Dynamic Properties of an Inositol 1,4,5-Trisphosphate– and Thapsigargin-insensitive Calcium Pool in Mammalian Cell Lines

1997 • 76 citations

Polarization of pseudopodial activities: cytoskeletal mechanisms

1991 • 76 citations

Signaling pathways underlying eosinophil cell motility revealed by using caged peptides

1998 • 74 citations

Intracellular free calcium responses during chemotaxis of Dictyostelium cells

1996 • 73 citations

Differential Effects of a Mitogen-Activated Protein Kinase Kinase Inhibitor on Human Neutrophil Responses to Chemotactic Factors

1997 • 72 citations

Regulation of neutrophil motility and adhesion by intracellular calcium transients.

1993 • 70 citations

Activation of MAP kinase-activated protein kinase 2 in human neutrophils after phorbol ester or fMLP peptide stimulation

1996 • 69 citations

Phospholipase D Regulation by a Physical Interaction with the Actin-Binding Protein Gelsolin

1996 • 67 citations

Changes in the distribution of LFA-1, catenins, and F-actin during transendothelial migration of monocytes in culture

1997 • 67 citations

Shape oscillations of human neutrophil leukocytes: characterization and relationship to cell motility

1996 • 66 citations

HIV and the 7-Transmembrane Domain Receptors

1996 • 65 citations

Eosinophil priming by cytokines: from cellular signal to in vivo modulation.

1996 • 65 citations

Mediation of chemoattractant-induced changes in [Ca2+]i and cell shape, polarity, and locomotion by InsP3, DAG, and protein kinase C in newt eosinophils.

1994 • 64 citations

Intracellular calcium and calcineurin regulate neutrophil motility on vitronectin through a receptor identified by antibodies to integrins alphav and beta3

1996 • 64 citations

Undifferentiated U937 cells transfected with chemoattractant receptors: a model system to investigate chemotactic mechanisms and receptor structure/function relationships

1997 • 63 citations

Protein Kinase C-δ Associates with Vimentin Intermediate Filaments in Differentiated HL60 Cells

1996 • 62 citations

CD11b/CD18 mediates the neutrophil chemotactic activity of fibrin degradation product D domain.

1997 • 62 citations

Polymorphonuclear leukocyte locomotion is insensitive to lowered cytoplasmic calcium levels

1988 • 62 citations

Low-molecular-weight GTP-binding proteins and leukocyte signal transduction

1995 • 61 citations

Fibronectin enhances the migration rate of human neutrophils in vitro

1996 • 61 citations

Differential localization of myosin and myosin phosphatase subunits in smooth muscle cells and migrating fibroblasts.

1997 • 61 citations

Functional, morphological, and phenotypical differences between rat alveolar and interstitial macrophages.

1997 • 60 citations

Phosphorylation-Dependent Control of Structures of Intermediate Filaments: A Novel Approach Using Site- and Phosphorylation State-Specific Antibodies

1997 • 59 citations

Expression and regulation of monocyte chemoattractant protein‐1 by human eosinophils

1997 • 59 citations

Cell Crawling: First the Motor, Now the Transmission

1998 • 59 citations

Unconventional myosins: new frontiers in actin-based motors

1997 • 56 citations

Mapmodulin: A possible modulator of the interaction of microtubule-associated proteins with microtubules

1997 • 55 citations

Substance P promotes lymphocyte-endothelial cell adhesion preferentially via LFA-1/ICAM-1 interactions

1996 • 54 citations

Unidirectional heterologous receptor desensitization between both the fMLP and C5a receptor and the IL-8 receptor

1996 • 54 citations

Effect of lipopolysaccharide on mitogen-activated protein kinases and cytosolic phospholipase A2

1995 • 53 citations

Eosinophil degranulation in the presence of bronchial epithelial cells. Effect of cytokines and role of adhesion.

1996 • 53 citations

Eotaxin Stimulates Eosinophil Adhesion to Human Lung Microvascular Endothelial Cells

1996 • 53 citations

CD1lb/CD 18 Mediates the Neutrophil Chemotactic Activity of Fibrin Degradation Product D Domain

1997 • 53 citations

Cyclic guanosine monophosphate-dependent protein kinase is targeted to intermediate filaments and phosphorylates vimentin in A23187-stimulated human neutrophils

1995 • 52 citations

Localised and global cytosolic Ca2+ changes in neutrophils during engagement of Cd11b/CD18 integrin visualised using confocal laser scanning reconstruction

1996 • 49 citations

Conserved regions in the cytoplasmic domains of the leukocyte integrin alpha L beta 2 are involved in endoplasmic reticulum retention, dimerization, and cytoskeletal association.

1995 • 48 citations

The response of human neutrophils to a chemotactic tripeptide (N-formyl- methionyl-leucyl-phenylalanine) studied by microcinematography

1984 • 47 citations

Actin polymerization in human eosinophils, unlike human neutrophils, depends on intracellular calcium mobilization

1996 • 47 citations

Two Phases of Pseudopod Protrusion in Tumor Cells Revealed by a Micropipette

1994 • 46 citations

Effects of buffering intracellular free calcium on neutrophil migration through three-dimensional matrices

1997 • 45 citations

Human C1q Induces Eosinophil Migration

1996 • 45 citations

Dictyostelium cell shape generation requires myosin II

1996 • 44 citations

Chemotaxis of newt eosinophils: calcium regulation of chemotactic response

1993 • 43 citations

Structural and Mechanistic Features of Phospholipases C: Effectors of Inositol Phospholipid-Mediated Signal Transduction

1997 • 43 citations

Dissection of Protein Kinase Cascades That Mediate Cellular Response to Cytokines and Cellular Stress

1996 • 43 citations

Rapid, microtubule-dependent fluctuations of the cell margin

1997 • 43 citations

Phosphatidic acid elicits calcium mobilization and actin polymerization through a tyrosine kinase-dependent process in human neutrophils: a mechanism for induction of chemotaxis

1997 • 41 citations

α-Actinin and vinculin in human neutrophils: reorganization during adhesion and relation to the actin network

1992 • 40 citations

Colchicine‐induced stimulation of PMN motility related to cytoskeletal changes in actin, α‐actinin, and myosin

1993 • 40 citations

Early Ca2+ signalling events in neutrophils detected by rapid confocal laser scanning

1995 • 40 citations

Domain-specific Interactions between Entactin and Neutrophil Integrins:

1996 • 40 citations

Actin polymerization in human eosinophils, unlike human neutrophils, depends on intracellular calcium mobilization

1996 • 40 citations

Mechanisms of Neutrophil and Eosinophil AccumulationIn Vivo

1993 • 40 citations

The Molecular Mechanism of Organelle Transport along Microtubules: The Identification and Characterization of Kifs (Kinesin Superfamily Proteins).

1996 • 39 citations

Cell motility, a principal requirement for metastasis

1991 • 39 citations

Phospholipase D mediates Fcγ receptor activation of neutrophils and provides specificity between high-valency immune complexes and fMLP signaling pathways

1997 • 37 citations

Gq Pathway Desensitizes Chemotactic Receptor-induced Calcium Signaling via Inositol Trisphosphate Receptor Down-regulation

1995 • 37 citations

Immunoregulatory Effect of Substance P in Human Eosinophil Migratory Function

1996 • 36 citations

Intracellular pattern of cytosolic Ca2+ changes during adhesion and multiple phagocytosis in human neutrophils. Dynamics of intracellular Ca2+ stores

1995 • 36 citations

Actin polymerization in neutrophils is triggered without a requirement for a rise in cytoplasmic Ca2+

1990 • 36 citations

The Role of the Endothelium in Inflammation and Tumor Metastasis

1997 • 35 citations

Extensive Contact between Gi2 and N-Formyl Peptide Receptor of Human Neutrophils: Mapping of Binding Sites Using Receptor-Mimetic Peptides

1995 • 35 citations

Detection of C5a receptors on human eosinophils and inhibition of eosinophil effector functions by anti‐C5a receptor (CD88) antibodies

1996 • 35 citations

The role of microtubule dependent motors in centrosome movements and spindle pole organization during mitosis

1996 • 34 citations

Clq enhancement of IgG-dependent eosinophil-mediated killing of schistosomula in vitro.

1987 • 34 citations

Cardiovascular and behavioural effects of intracerebroventricularly administered tachykinin NK₃ receptor antagonists in the conscious rat

1997 • 34 citations

Microtubules can modulate pseudopod activity from a distance inside macrophages

1996 • 33 citations

Ligation of members of the beta 1 or the beta 2 subfamilies of integrins by antibodies triggers eosinophil respiratory burst and spreading.

1993 • 32 citations

Reversible Translocation of Phosphoinositide 3-Kinase to the Cytoskeleton of ADP-aggregated Human Platelets Occurs Independently of Rho A and without Synthesis of Phosphatidylinositol (3,4)-Bisphosphate

1997 • 31 citations

Integrin-dependent role of human T cell matrix metalloproteinase activity in chemotaxis through a model basement membrane.

1996 • 31 citations

Calcium waves, gradients and oscillations

1995 • 31 citations

Macrophage arachidonate release via both the cytosolic Ca2+-dependent and -independent phospholipases is necessary for cell spreading

1997 • 30 citations

Leukotriene B4 and platelet activating factor production in permeabilized human neutrophils: role of cytosolic PLA2 in LTB4 and PAF generation

1996 • 30 citations

Basic Fibroblast Growth Factor Is a Signal for the Initiation of Centrosome Redistribution to the Front of Migrating Endothelial Cells at the Edge of an In Vitro Wound

1995 • 29 citations

Regulation of Guanylyl Cyclase by a cGMP-binding Protein during Chemotaxis in Dictyostelium discoideum

1996 • 28 citations

Transient increase of free cytosolic calcium during neutrophil motility responses

1997 • 28 citations

Involvement of multiple kinases in neutrophil activation.

1993 • 28 citations

Protein kinase C and calcium/calmodulin-dependent protein kinase II phosphorylate three-repeat and four-repeat tau isoforms at different rates.

1997 • 28 citations

Defective microtubule reorganization in phorbol ester-resistant U937 variants: reconstitution of the normal cell phenotype with nocodazole treatment.

1997 • 26 citations

Role of gelsolin in actin depolymerization of adherent human neutrophils.

1997 • 26 citations

The Chemokines: Cytokines that Direct Leukocyte Migration

1996 • 26 citations

Elastin‐derived peptide induces monocyte chemotaxis by increasing intracellular cyclic GMP level and activating cyclic GMP dependent protein kinase

1997 • 26 citations

Mechanisms Involved in Activation of Human Eosinophil Exocytosis by Substance P: An in Vitro Model of Sensory Neuroimmunomodulation

1997 • 24 citations

The stimulation of human neutrophil migration by angiotensin II: its dependence on Ca²⁺and the involvement of cyclic GMP

1997 • 24 citations

SINGLE CELL IMAGING REVEALS ABNORMAL INTRACELLULAR CALCIUM SIGNALS WITHIN RHEUMATOID SYNOVIAL NEUTROPHILS

1991 • 23 citations

Cellular regulation of arachidonate mobilization and metabolism

1995 • 23 citations

Getting to the heart of β-tubulin

1996 • 23 citations

Integrin-dependent role of human T cell matrix metalloproteinase activity in chemotaxis through a model basement membrane

1996 • 23 citations

Purification and Properties of a Ca²⁺-Independent Barbed-End Actin Filament Capping Protein, CapZ, from Human Polymorphonuclear Leukocytes

1996 • 23 citations

Researchers in cell motility and the cytoskeleton can play major roles in understanding AIDS

1997 • 23 citations

Signal transduction and motility of Dictyostelium

1995 • 22 citations

Polarization and chemokinesis of ovine and human neutrophils in response to Fasciola hepatica excretory-secretory products

1996 • 22 citations

Random migration of polymorphonuclear leukocytes induced by GM-CSF involving a signal transduction pathway different from that of fMLP

1997 • 22 citations

Tyrosine phosphorylation of 100–115 kDa proteins by phosphatidic acid generated via phospholipase D activation in HL60 granulocytes

1997 • 22 citations

The microanatomy of calcium stores in human neutrophils: relationship of structure to function.

1997 • 19 citations

Leukotriene A₄, and not leukotriene B₄, is the main 5‐lipoxygenase metabolite released by bovine leukocytes

1996 • 19 citations

Changes in mononuclear phagocyte microtubules after endotoxin stimulation. II. Changes in microtubule composition.

1997 • 19 citations

Identification Enzymatically Active Ca2+/Calmodulin-Dependent Proteon Kinase in Centrosomes of Hemopoietic Cells

1995 • 19 citations

Reduction by inhibitors of mono(ADP‐ribosyl)transferase of chemotaxis in human neutrophil leucocytes by inhibition of the assembly of filamentous actin

1996 • 19 citations

Simultaneous digital imaging analysis of cytosolic calcium and morphological change in platelets activated by surface contact

1996 • 19 citations

Changes in mononuclear phagocyte microtubules after endotoxin stimulation. I. Changes in microtubule stability.

1997 • 19 citations

Controlling the molecular motor of neutrophil chemotaxis

1997 • 18 citations

Chemokines: structure, receptors and functions. A new target for inflammation and asthma therapy?

1996 • 17 citations

A possible role for mono(ADP‐ribosyl)transferase in the signalling pathway mediating neutrophil chemotaxis

1996 • 16 citations

Priming of eosinophil recruitment in vivo by LPS pretreatment.

1996 • 16 citations

Adhesion molecule expression on eosinophils in idiopathic eosinophilic pneumonia

1996 • 16 citations

Development of polarity in human erythroleukemia cells: Roles of membrane ruffling and the centrosome

1997 • 16 citations

Ryanodine as inhibitor of chemotactic peptide-induced chemotaxis in human neutrophils

1995 • 16 citations

Modifications of the golgi apparatus inSaccharomyces cerevisiae lacking microtubules

1996 • 16 citations

Regulation of kinesin and cytoplasmic dynein-driven organelle motility

1996 • 15 citations

Identification of Fusion Regulatory Protein (FRP)-1/4F2 Related Molecules: Cytoskeletal Proteins are Associated with FRP-1 Molecules that Regulate Multinucleated Giant Cell Formation of Monocytes and HIV-Induced Cell Fusion.

1995 • 15 citations

Rapid redistribution of myosin II in livingDictyostelium amoebae, as revealed by fluorescent probes introduced by electroporation

1996 • 13 citations

Eosinophil chemotactic activity in Leishmania amazonensis promastigotes

1996 • 13 citations

Sphingolipid-Dependent Protein Kinases

1996 • 13 citations

Affinity purification and subcellular localization of kinesin in human neutrophils

1993 • 13 citations

Temporal and Spatial Resolution of Ca2+Release and Influx in Human Neutrophils Using a Novel Confocal Laser Scanning Mode

1996 • 12 citations

Pharmacologic Study of Basophil Histamine Release Induced by Monocyte Chemotactic Protein-1 with Kinase Inhibitors

1996 • 12 citations

Leukotriene B4 stimulates the release of arachidonate in human neutrophils via the action of cytosolic phospholipase A2

1997 • 12 citations

Exogenous phosphatidic acid with saturated short-chain fatty acyl groups induces superoxide anion release from guinea pig peritoneal polymorphonuclear leukocytes by three different mechanisms

1997 • 12 citations

Role of leukotriene B₄ in the interleukin‐4‐induced human mononuclear phagocyte activation

1996 • 12 citations

Does Actin Polymerization Status Modulate Ca2+Storage in Human Neutrophils? Release and Coalescence of Ca2+Stores by Cytochalasins

1997 • 11 citations

Dynamic properties of nucleated microtubules: GTP utilisation in the sub-critical concentration regime

1996 • 10 citations

Capacitative Ca2+ entry – sifting through the evidence for CIF

1996 • 10 citations

The role of eosinophils in interleukin-2/lymphokine-activated killer cell therapy.

1993 • 9 citations

Eosinophil migration in response to three molecular species of platelet activating factor

1996 • 9 citations

Making a connection: The “other” microtubule end

1996 • 8 citations

Guanylate cyclase activity in permeabilizedDictyostelium discoideum cells

1996 • 8 citations

The Effect of Thimerosal on Neutrophil Migration

1998 • 8 citations

Mechanical models of pseudopod formation.

1993 • 7 citations

Studies of mechanical aspects of amoeboid locomotion.

1993 • 7 citations

Dot-like focal contacts in adherent eosinophils, their redistribution into peripheral belts, and correlated effects on cell migration and protected zone formation

1996 • 7 citations

Leukotriene C4 from vascular endothelium enhances neutrophil adhesiveness

1997 • 6 citations

Cell Polarization as a Possible Mechanism of Response Termination

1996 • 5 citations

METCHNIKOFF'S LIFE AND SCIENTIFIC CONTRIBUTIONS IN HISTORICAL PERSPECTIVE*

1982 • 5 citations

Ca2+ Signalling Delays in Neutrophils: Effects of Prior Exposure to Platelet Activating Factor or Formyl-met-leu-phe

1998 • 5 citations

The ultrastructure of Entamoeba histolytica locomotion.

1996 • 4 citations

A subpopulation analysis of f-MLP stimulated granulocytes migrating in filters

1996 • 3 citations

The effects of platelet activating factor and retinoic acid on the expression of ELAM‐1 and ICAM‐1 and the functions of neutrophils

1995 • 2 citations

Molecular Basis for Leukocyte Adhesion Molecule Deficiency

1993 • 2 citations