Cell adhesion and angiogenesis.

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Tumor Angiogenesis: Therapeutic Implications

1971 • 9,898 citations

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Requirement of Vascular Integrin α _v β ₃ for Angiogenesis

1994 • 3,016 citations

Role of cell shape in growth control

1978 • 2,434 citations

Clinical Applications of Research on Angiogenesis

1995 • 2,300 citations

Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1994 • 2,293 citations

Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity

1995 • 1,608 citations

Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3

1996 • 1,555 citations

The extracellular matrix as a cell survival factor.

1993 • 1,541 citations

Definition of Two Angiogenic Pathways by Distinct α _v Integrins

1995 • 1,333 citations

Life, death, and the pursuit of apoptosis.

1996 • 1,333 citations

Regulation of development and differentiation by the extracellular matrix

1993 • 1,216 citations

Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures.

1988 • 1,209 citations

Intratumor microvessel density as a prognostic factor in cancer.

1995 • 881 citations

Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix.

1989 • 877 citations

Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin.

1995 • 840 citations

Two different laminin domains mediate the differentiation of human endothelial cells into capillary-like structures in vitro

1989 • 746 citations

Pericytes in the microvasculature

1996 • 726 citations

Differentiation of endothelium

1995 • 617 citations

Multi‐faceted regulation of cell differentiation by extracellular matrix

1993 • 610 citations

Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1

1995 • 599 citations

Susceptibility to Infection and Altered Hematopoiesis in Mice Deficient in Both P- and E-Selectins

1996 • 534 citations

Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1.

1991 • 510 citations

Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells.

1994 • 504 citations

Fibronectin controls capillary endothelial cell growth by modulating cell shape.

1990 • 498 citations

Endothelial cell‐to‐cell junctions

1995 • 481 citations

Identification of an Inhibitor of Neovascularization from Cartilage

1990 • 481 citations

Tumor-promoting phorbol esters induce angiogenesis in vitro

1985 • 470 citations

In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases.

1989 • 462 citations

Apoptosis and the cell cycle

1995 • 431 citations

Changes in the vascular extracellular matrix during embryonic vasculogenesis and angiogenesis

1988 • 410 citations

Regulation of matrix metalloproteinase expression in human vein and microvascular endothelial cells. Effects of tumour necrosis factor α, interleukin 1 and phorbol ester

1993 • 388 citations

Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis.

1996 • 385 citations

Characterization of E-selectin-deficient mice: Demonstration of overlapping function of the endothelial selectins

1994 • 384 citations

Endothelial adherens junctions: implications in the control of vascular permeability and angiogenesis.

1996 • 372 citations

CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium.

1995 • 367 citations

Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor–type integrins inhibits retinal neovascularization

1996 • 336 citations

Affinity of integrins for damaged extracellular matrix: αvβ3 binds to denatured collagen type I through RGD sites

1992 • 326 citations

Molecular cloning and expression of murine vascular endothelial- cadherin in early stage development of cardiovascular system

1996 • 325 citations

An antagonist of integrin αvβ3 prevents maturation of blood vessels during embryonic neovascularization

1995 • 304 citations

Inhibition of angiogenesis by tissue inhibitor of metalloproteinase

1994 • 299 citations

Integrins as dynamic regulators of vascular function

1994 • 289 citations

Embryonic lethal mutation in mouse collagen I gene causes rupture of blood vessels and is associated with erythropoietic and mesenchymal cell death

1984 • 285 citations

Adhesive interactions of sickle erythrocytes with endothelium.

1997 • 270 citations

Effects of fluid dynamic forces on vascular cell adhesion.

1996 • 263 citations

Extracellular matrix and cell shape: Potential control points for inhibition of angiogenesis

1991 • 247 citations

Interstitial Collagenase Is Required for Angiogenesis in Vitro

1994 • 231 citations

Expression of P-selectin on Endothelial Cells is Upregulated by LPS and TNF-α in Vivo

1994 • 226 citations

Integrin and Arg-Gly-Asp Dependence of Cell Adhesion to the Native and Unfolded Triple Helix of Collagen Type VI

1993 • 212 citations

A role for sialyl Lewis-X/A glycoconjugates in capillary morphogenesis

1993 • 211 citations

Blood Vessel Fibronectin Increases in Conjunction with Endothelial Cell Proliferation and Capillary Ingrowth During Wound Healing

1982 • 211 citations

Control of Growth and Differentiation of Vascular Cells by Extracellular Matrix Proteins

1991 • 204 citations

Differential expression of extracellular proteins is correlated with angiogenesis in vitro.

1991 • 199 citations

In vitro model of angiogenesis using a human endothelium‐derived permanent cell line: Contributions of induced gene expression, G‐proteins, and integrins

1992 • 198 citations

Regulation of in vitro capillary tube formation by anti-integrin antibodies.

1993 • 194 citations

Platelet vitronectin receptor expression differentiates Iraqi-Jewish from Arab patients with Glanzmann thrombasthenia in Israel

1991 • 173 citations

The role of vascular endothelial growth factor in blood vessel formation

1996 • 163 citations

E-selectin is present in proliferating endothelial cells in human hemangiomas.

1996 • 159 citations

Induction of angiogenesis in chick yolk-sac membrane by polyamines and its inhibition by tissue inhibitors of metalloproteinases (TIMP and TIMP-2)

1990 • 154 citations

Approaches to studying cell adhesion molecules in angiogenesis

1995 • 127 citations

The microvascular extracellular matrix. Developmental changes during angiogenesis in the aortic ring-plasma clot model.

1987 • 118 citations

Pericytes in the microvasculature

1996 • 112 citations

The extracellular matrix as a cell cycle control element in atherosclerosis and restenosis.

1997 • 107 citations

Therapeutic inhibition of carbohydrate-protein interactions in vivo.

1997 • 104 citations

Cell adhesion molecules in angiogenesis

1996 • 97 citations

Human microvascular endothelial cells express integrin‐related complexes that mediate adhesion to the extracellular matrix

1989 • 93 citations

Astrocytes modulate retinal vasculogenesis: effects on fibronectin expression

1994 • 87 citations

Inhibitors of basement membrane collagen synthesis prevent endothelial cell alignment in matrigel in vitro and angiogenesis in vivo.

1994 • 81 citations

Inhibition of angiogenesis in vitro by Arg-Gly-Asp-containing synthetic peptide.

1991 • 77 citations

1-Deoxymannojirimycin inhibits capillary tube formation in vitro. Analysis of N-linked oligosaccharides in bovine capillary endothelial cells.

1992 • 63 citations

Intercellular adhesion molecule-3 on endothelial cells. Expression in tumors but not in inflammatory responses.

1996 • 59 citations

Identification of a role of the vitronectin receptor and protein kinase C in the induction of endothelial cell vascular formation

1993 • 56 citations

Expression of platelet‐endothelial cell adhesion molecule‐1 (PECAM‐1) during melanoma‐induced angiogenesis in vivo

1993 • 49 citations

Cell Adhesion: Fibronectin and integrin knockouts come unstuck

1994 • 42 citations

Novel Synthetic Analogs of Sialyl Lewis X Can Inhibit Angiogenesisin Vitroandin Vivo

1996 • 33 citations

Microvascular endothelial cells from E-selectin-deficient mice form tubes in vitro.

1996 • 28 citations

A second case of variant of Glanzmann's thrombasthenia due to substitution of platelet GPIII (integrinβ₃) Arg214 by Trp

1993 • 27 citations