Discrete Steps in Binding and Signaling of Interleukin-8 with Its Receptor

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines.

1994 • 2,251 citations

lnterleukin-8 and Related Chemotactic Cytokines—CXC and CC Chemokines

1993 • 1,650 citations

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

1993 • 1,213 citations

Structure and Functional Expression of a Human Interleukin-8 Receptor

1991 • 1,088 citations

STRUCTURE AND FUNCTION OF G PROTEIN-COUPLED RECEPTORS

1994 • 1,070 citations

Cloning of Complementary DNA Encoding a Functional Human Interleukin-8 Receptor

1991 • 878 citations

Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils.

1996 • 719 citations

A novel neutrophil-activating factor produced by human mononuclear phagocytes.

1988 • 655 citations

Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils.

1996 • 626 citations

Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.

1992 • 587 citations

Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8

1993 • 529 citations

Structure-activity relationships of interleukin-8 determined using chemically synthesized analogs. Critical role of NH2-terminal residues and evidence for uncoupling of neutrophil chemotaxis, exocytosis, and receptor binding activities.

1991 • 425 citations

G protein-coupled signal transduction pathways for interleukin-8

1993 • 385 citations

Scanning mutagenesis of interleukin-8 identifies a cluster of residues required for receptor binding.

1991 • 372 citations

IL-8 induces neutrophil chemotaxis predominantly via type I IL-8 receptors.

1995 • 353 citations

The interleukin-8-related chemotactic cytokines GRO alpha, GRO beta, and GRO gamma activate human neutrophil and basophil leukocytes

1993 • 279 citations

Different functions for the interleukin 8 receptors (IL-8R) of human neutrophil leukocytes: NADPH oxidase and phospholipase D are activated through IL-8R1 but not IL-8R2.

1996 • 271 citations

Biology of chemokine and classical chemoattractant receptors: differential requirements for adhesion-triggering versus chemotactic responses in lymphoid cells.

1996 • 265 citations

Two-site binding of C5a by its receptor: analternative binding paradigm for G protein-coupled receptors.

1994 • 236 citations

Monoclonal antibodies detect different distribution patterns of IL-8 receptor A and IL-8 receptor B on human peripheral blood leukocytes.

1994 • 222 citations

Inhibition of lung inflammatory reactions in rats by an anti-human IL-8 antibody.

1993 • 183 citations

Structural requirements for interleukin-8 function identified by design of analogs and CXC chemokine hybrids.

1994 • 182 citations

Amino terminus of the interleukin-8 receptor is a major determinant of receptor subtype specificity.

1992 • 173 citations

Expression of monocyte chemoattractant protein‐1 and interleukin‐8 receptors on subsets of T cells: correlation with transendothelial chemotactic potential

1996 • 169 citations

CXC Chemokines Bind to Unique Sets of Selectivity Determinants That Can Function Independently and Are Broadly Distributed on Multiple Domains of Human Interleukin-8 Receptor B

1996 • 151 citations

Neutralization of IL-8 inhibits neutrophil influx in a rabbit model of endotoxin-induced pleurisy.

1994 • 142 citations

Importance of the amino terminus of the interleukin-8 receptor in ligand interactions.

1993 • 141 citations

Complete mutagenesis of the extracellular domain of interleukin-8 (IL-8) type A receptor identifies charged residues mediating IL-8 binding and signal transduction.

1994 • 140 citations

Interleukin-8 antagonists generated by N-terminal modification.

1993 • 138 citations

Partial functional mapping of the human interleukin-8 type A receptor. Identification of a major ligand binding domain.

1993 • 132 citations

Physical Association of Gi2α with Interleukin-8 Receptors

1996 • 78 citations

Receptor Recognition and Specificity of Interleukin-8 Is Determined by Residues That Cluster Near a Surface-accessible Hydrophobic Pocket

1996 • 67 citations

Mutagenesis Studies of Interleukin-8

1996 • 64 citations

Neutralizing monoclonal antibodies to human IL-8 receptor A map to the NH2-terminal region of the receptor.

1994 • 40 citations