A novel type of myosin implicated in signalling by rho family GTPases.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Three-dimensional structure of myosin subfragment-1: a molecular motor

1993 • 2,027 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Single myosin molecule mechanics: piconewton forces and nanometre steps

1994 • 1,894 citations

Structure of the actin-myosin complex and its implications for muscle contraction

1993 • 1,756 citations

The insulin signaling system.

1994 • 1,733 citations

[12] Determination of total protein

1983 • 1,309 citations

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

1994 • 617 citations

cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

1991 • 585 citations

Identification of a Protein that Binds to the SH3 Region of Abl and Is Similar to Bcr and GAP-rho

1992 • 553 citations

Novel myosin heavy chain encoded by murine dilute coat colour locus

1991 • 534 citations

Binding of 14-3-3 Proteins to the Protein Kinase Raf and Effects on Its Activation

1994 • 415 citations

The protein kinase C family

1992 • 399 citations

Unconventional myosins

1992 • 374 citations

Regulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI).

1993 • 363 citations

Structure of the actin–myosin interface

1981 • 349 citations

Molecular cloning of cDNAs encoding the GAP-associated protein p190: Implications for a signaling pathway from ras to the nucleus

1992 • 343 citations

Association between GTPase activators for Rho and Ras families

1992 • 322 citations

The Drosophila ninaC locus encodes two photoreceptor cell specific proteins with domains homologous to protein kinases and the myosin heavy chain head

1988 • 306 citations

Stimulatory Effects of Yeast and Mammalian 14-3-3 Proteins on the Raf Protein Kinase

1994 • 299 citations

Structure of the regulatory domain of scallop myosin at 2.8 Ä resolution

1994 • 296 citations

Three-dimensional atomic model of F-actin decorated with Dictyostelium myosin S1

1993 • 287 citations

Phylogenetic analysis of the myosin superfamily

1993 • 258 citations

A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans.

1991 • 255 citations

MYOSIN-I

1991 • 252 citations

Single-Molecule Analysis of the Actomyosin Motor Using Nano-Manipulation

1994 • 208 citations

The cysteine-rich region of raf-1 kinase contains zinc, translocates to liposomes, and is adjacent to a segment that binds GTP-ras

1994 • 202 citations

Enzymatic activities correlate with chimaeric substitutions at the actin-binding face of myosin

1994 • 197 citations

Identification and Characterization of Zinc Binding Sites in Protein Kinase C

1991 • 193 citations

Location of SH-1 and SH-2 in the heavy chain segment of heavy meromyosin

1978 • 186 citations

Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene

1990 • 174 citations

The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization

1992 • 170 citations

Characterization of the calmodulin binding domain of neuromodulin. Functional significance of serine 41 and phenylalanine 42.

1991 • 165 citations

Molecular evolution of the myosin family: relationships derived from comparisons of amino acid sequences.

1993 • 164 citations

Proteolytic approach to structure and function of actin recognition site in myosin heads

1981 • 164 citations

Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types.

1994 • 159 citations

The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-rafcarrying retrovirus

1987 • 145 citations

Human brain n-chimaerin cDNA encodes a novel phorbol ester receptor

1990 • 136 citations

Purification, cDNA‐cloning and expression of human diacylglycerol kinase

1990 • 124 citations

Evidence for inserted sequences in the head region of nonmuscle myosin specific to the nervous system. Cloning of the cDNA encoding the myosin heavy chain-B isoform of vertebrate nonmuscle myosin.

1992 • 121 citations

Zinc finger domains and phorbol ester pharmacophore. Analysis of binding to mutated form of protein kinase C zeta and the vav and c-raf proto-oncogene products

1994 • 120 citations

Identification, characterization and cloning of myr 1, a mammalian myosin-I.

1993 • 107 citations

Rat myr 4 defines a novel subclass of myosin I: identification, distribution, localization, and mapping of calmodulin-binding sites with differential calcium sensitivity.

1994 • 106 citations

A phorbol ester binding domain of protein kinase C gamma. Deletion analysis of the Cys2 domain defines a minimal 43-amino acid peptide.

1994 • 105 citations

Germ cell beta-chimaerin, a new GTPase-activating protein for p21rac, is specifically expressed during the acrosomal assembly stage in rat testis.

1993 • 104 citations

The Primary Structure of Skeletal Muscle Myosin Heavy Chain: IV. Sequence of the Rod, and the Complete 1,938-Residue Sequence of the Heavy Chain

1991 • 83 citations

A phorbol ester binding domain of protein kinase C gamma. High affinity binding to a glutathione-S-transferase/Cys2 fusion protein.

1994 • 77 citations

bcr genes and transcripts.

1988 • 74 citations

Human ABR encodes a protein with GAPrac activity and homology to the DBL nucleotide exchange factor domain

1993 • 70 citations

Novel myosins

1991 • 69 citations

Breakpoint cluster region gene product-related domain of n-chimaerin. Discrimination between Rac-binding and GTPase-activating residues by mutational analysis

1994 • 52 citations

A Drosophila rotund transcript expressed during spermatogenesis and imaginal disc morphogenesis encodes a protein which is similar to human Rac GTPase-activating (racGAP) proteins.

1992 • 43 citations