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P<scp>hysiological</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponse and</scp>I<scp>nflammatory</scp>T<scp>issue</scp>D<scp>amage by</scp>H<scp>ypoxia</scp>-I<scp>nducible</scp>F<scp>actors and</scp>A<scp>denosine</scp>A2AR<scp>eceptors</scp>

Data up to Jan 2025

Published2004
Citations672
References127

Total Citations Per Year

Abstract

References (127)

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A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice.

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A monoclonal antibody to the membrane glycoprotein complex CD18 inhibits polymorphonuclear leukocyte accumulation and plasma leakage in vivo

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Hypoxia-Inducible Factor 1α Is Essential for Cell Cycle Arrest during Hypoxia

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Energy Metabolism of Human Neutrophils during Phagocytosis

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A2AAdenosine Receptor Deficiency Attenuates Brain Injury Induced by Transient Focal Ischemia in Mice

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Heat Shock Proteins, Inflammation, and Cardiovascular Disease

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Hypoxia-Induced Inhibition of Adenosine Kinase Potentiates Cardiac Adenosine Release

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Role of Inflammatory Mediators in Thrombogenesis

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Inflammatory Cytokines Regulate Function and Expression of Adenosine A2A Receptors in Human Monocytic THP-1 Cells

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Adenosine affects expression of membrane molecules, cytokine and chemokine release, and the T-cell stimulatory capacity of human dendritic cells

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1999 • 218 citations

Hypoxic Preconditioning Induces Changes in HIF-1 Target Genes in Neonatal Rat Brain

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Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor kappaB activation

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IFN-gamma up-regulates the A2B adenosine receptor expression in macrophages: a mechanism of macrophage deactivation.

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Adenosine A2AReceptors are Colocalized with and Activate Golfin Rat Striatum

2000 • 191 citations

Memory of Extracellular Adenosine A2A Purinergic Receptor-mediated Signaling in Murine T Cells

1997 • 188 citations

Stimulation of the Mitogen-activated Protein Kinase via the A2A-Adenosine Receptor in Primary Human Endothelial Cells

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Expression and function of adenosine receptors in human dendritic cells

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Evidence for Adenosine/Dopamine Receptor Interactions Indications for Heteromerization

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Use of the A2A adenosine receptor as a physiological immunosuppressor and to engineer inflammation in vivo

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Patterns of A2A extracellular adenosine receptor expression in different functional subsets of human peripheral T cells. Flow cytometry studies with anti-A2A receptor monoclonal antibodies.

1999 • 163 citations

Inflammation in acute coronary syndromes

2002 • 159 citations

Cyclic AMP‐dependent inhibition of human neutrophil oxidative activity by substituted 2‐propynylcyclohexyl adenosine A2A receptor agonists

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IFN-γ Up-Regulates the A2B Adenosine Receptor Expression in Macrophages: A Mechanism of Macrophage Deactivation

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Activation of Mitogen-activated Protein Kinase by the A2A-adenosine Receptor via a rap1-dependent and via a p21 -dependent Pathway

1999 • 121 citations

Regional manifestations and control of the immune system

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Adenosine A 2A Receptor Stimulation Reduces Inflammation and Neointimal Growth in a Murine Carotid Ligation Model

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cAMP-elevating agents suppress dendritic cell function

2001 • 109 citations

Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling

2001 • 107 citations

The Role of Nitric Oxide (NO) in Stability Regulation of Hypoxia Inducible Factor-1&amp;#945; (HIF-1&amp;#945;)

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Indoleamine 2,3-dioxygenase, immunosuppression and pregnancy

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Induction and Direction of Immune Responses by Vaccine Adjuvants

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Differential Regulation of Two Alternatively Spliced Isoforms of Hypoxia-inducible Factor-1α in Activated T Lymphocytes

2001 • 98 citations

Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling

2001 • 98 citations

Aggravated Brain Damage After Hypoxic Ischemia in Immature Adenosine A 2A Knockout Mice

2003 • 93 citations

Synthesis, Biological Activity, and Molecular Modeling Investigation of New Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine Derivatives as Human A3 Adenosine Receptor Antagonists

2002 • 93 citations

Human A2AAdenosine Receptors: High-Affinity Agonist Binding to Receptor-G Protein Complexes Containing Gβ4

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Occupancy of adenosine receptors raises cyclic AMP alone and in synergy with occupancy of chemoattractant receptors and inhibits membrane depolarization

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Neoceptor Concept Based on Molecular Complementarity in GPCRs: A Mutant Adenosine A3 Receptor with Selectively Enhanced Affinity for Amine-Modified Nucleosides

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Analysis of A2a receptor-deficient mice reveals no significant compensatory increases in the expression of A2b, A1, and A3 adenosine receptors in lymphoid organs

2003 • 80 citations

Effects of extracellular ATP and adenosine on different thymocyte subsets: possible role of ATP-gated channels and G protein-coupled purinergic receptor.

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Hypoxia in the thymus: role of oxygen tension in thymocyte survival

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Effect of adenosine on the expression of β2 integrins and L-selectin of human polymorphonuclear leukocytes in vitro

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Gene dose effect reveals no Gs-coupled A2A adenosine receptor reserve in murine T-lymphocytes: studies of cells from A2A-receptor-gene-deficient mice

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Acting via A2 receptors, adenosine inhibits the production of tumor necrosis factor-alpha of endotoxin-stimulated human polymorphonuclear leukocytes.

1995 • 71 citations

Engagement of adenosine receptors inhibits hydrogen peroxide (H2O2−) release by activated human neutrophils

1987 • 70 citations

Effect of adenosine analogues and cAMP-raising agents on TNF-, GM-CSF–, and chemotactic peptide–induced degranulation in single adherent neutrophils

1992 • 63 citations

Recombinant human interleukin (IL)-1 beta-mediated regulation of hypoxia-inducible factor-1 alpha (HIF-1 alpha) stabilization, nuclear translocation and activation requires an antioxidant/reactive oxygen species (ROS)-sensitive mechanism.

2002 • 62 citations

Energy metabolism and T-cell-mediated cytolysis. I. Synergism between inhibitors of respiration and glycolysis.

1977 • 60 citations

Regulation of Coronary Blood Flow1

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Adenosine and related compounds counteract tumor necrosis factor-alpha inhibition of neutrophil migration: implication of a novel cyclic AMP-independent action on the cell surface.

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Adenosine production inside rat polymorphonuclear leucocytes

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A2A receptor dependent and A2A receptor independent effects of extracellular adenosine on murine thymocytes in conditions of adenosine deaminase deficiency

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The extracellular versus intracellular mechanisms of inhibition of TCR-triggered activation in thymocytes by adenosine under conditions of inhibited adenosine deaminase

1999 • 53 citations

Plasma adenosine levels increase in women with normal pregnancies

2000 • 50 citations

Inhibition of fMLP-triggered respiratory burst of human monocytes by adenosine: involvement of A3 adenosine receptor

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Cyclic AMP has the ability to influence multiple events during B cell stimulation

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Modulation of Leukocyte Behavior by an Inflamed Extracellular Matrix

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In vivo labelling of the adenosine A2A receptor in mouse brain using the selective antagonist [3H]SCH 58261

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Pentoxifylline does not act via adenosine receptors in the inhibition of the superoxide anion production of human polymorphonuclear leukocytes

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Lymphocyte Membrane Adenosine Receptors Coupled to Adenylate Cyclase Properties and Occurrence in Various Lymphocyte Subclasses

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In vitro, Candida albicans releases the immune modulator adenosine and a second, high-molecular weight agent that blocks neutrophil killing.

1992 • 34 citations

Effects of adenosine on the functions of circulating polymorphonuclear leukocytes during hyperdynamic endotoxemia

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Study of A2A adenosine receptor gene deficient mice reveals that adenosine analogue CGS 21680 possesses no A2A receptor‐unrelated lymphotoxicity

2000 • 31 citations

Adenosine analogue reduces spinal cord reperfusion injury in a time-dependent fashion

2001 • 29 citations

Modulation of the chemotactic peptide- and immunoglobulin G-triggered respiratory burst in human neutrophils by exogenous and endogenous adenosine

1998 • 24 citations

Classification of adenosine receptors.

1984 • 20 citations

THE RESPIRATION AND ENERGY METABOLISM OF SHEEP LYMPHOCYTES

1984 • 14 citations

Relationship between adenosine deaminase activity and cytokine-secreting T cells in normal pregnancy

2002 • 14 citations

Increased ratio between anaerobic and aerobic metabolism in lymphocytes from hyperthyroid patients

1994 • 12 citations

Adenosine Deaminase-Deficient Mice: Models for the Study of Lymphocyte Development and Adenosine Signaling

2006 • 6 citations

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PhysiologicalControl ofImmuneResponse andInflammatoryTissueDamage… (2004) – Annual Review of Immunology | Metascience Observatory Explorer