P<scp>hysiological</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponse and</scp>I<scp>nflammatory</scp>T<scp>issue</scp>D<scp>amage by</scp>H<scp>ypoxia</scp>-I<scp>nducible</scp>F<scp>actors and</scp>A<scp>denosine</scp>A2AR<scp>eceptors</scp>
Data up to Jan 2025
Total Citations Per Year
Abstract
References (127)
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
2003 • 7,170 citations
The immunopathogenesis of sepsis
2002 • 2,686 citations
International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors.
2001 • 2,470 citations
HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation
2003 • 1,909 citations
Regulation of Mammalian O2Homeostasis by Hypoxia-Inducible Factor 1
1999 • 1,882 citations
HIF-1: mediator of physiological and pathophysiological responses to hypoxia
2000 • 1,769 citations
The Instructive Role of Innate Immunity in the Acquired Immune Response
1996 • 1,731 citations
The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart1
1929 • 1,470 citations
Progress in human tumour immunology and immunotherapy
2001 • 1,327 citations
Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage
2001 • 1,261 citations
Neutrophils: Molecules, Functions and Pathophysiological Aspects
2000 • 1,104 citations
Hypoxia-inducible factor 1: master regulator of O2 homeostasis
1998 • 1,066 citations
Fundamental Immunology
1999 • 1,011 citations
Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation
2001 • 994 citations
CTLA-4-Mediated Inhibition in Regulation of T Cell Responses: Mechanisms and Manipulation in Tumor Immunotherapy
2001 • 964 citations
Neuroendocrine Regulation of Immunity
2002 • 941 citations
Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor
1997 • 906 citations
Polyunsaturated fatty acids, inflammation and immunity
2002 • 695 citations
Role of Cyclic Nucleotides in Growth Control
1975 • 692 citations
Molecular Approach to Adenosine Receptors: Receptor-Mediated Mechanisms of Tissue Protection
2001 • 685 citations
The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.
1993 • 658 citations
Ecto-5′-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia
2002 • 651 citations
Ecto-5′-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia
2002 • 604 citations
Chronic Inflammation and Cancer
2013 • 585 citations
Cytokine-induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11/CD18 integrins.
1989 • 577 citations
Adenosine, Adenosine Receptors and the Actions of Caffeine *
1995 • 563 citations
Structure and function of adenosine receptors and their genes
2000 • 562 citations
Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha /ARNT
1998 • 561 citations
Adenosine Receptor Subtypes: Characterization and Therapeutic Regulation
1995 • 540 citations
A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice.
1999 • 530 citations
A monoclonal antibody to the membrane glycoprotein complex CD18 inhibits polymorphonuclear leukocyte accumulation and plasma leakage in vivo
1987 • 525 citations
Hypoxia-Inducible Factor 1α Is Essential for Cell Cycle Arrest during Hypoxia
2002 • 508 citations
Role of A2a Extracellular Adenosine Receptor-Mediated Signaling in Adenosine-Mediated Inhibition of T-Cell Activation and Expansion
1997 • 479 citations
Energy Metabolism of Human Neutrophils during Phagocytosis
1982 • 458 citations
A2AAdenosine Receptor Deficiency Attenuates Brain Injury Induced by Transient Focal Ischemia in Mice
1999 • 457 citations
Neuroprotective role of adenosine in cerebral ischaemia
1992 • 450 citations
Dopamine D 1 and adenosine A 1 receptors form functionally interacting heteromeric complexes
2000 • 437 citations
Antioxidant and prooxidant mechanisms in the regulation of redox(y)-sensitive transcription factors
2002 • 426 citations
Adenosine and the concept of ‘retaliatory metabolites’
1984 • 422 citations
Adenosine: an endogenous inhibitor of neutrophil-mediated injury to endothelial cells.
1986 • 416 citations
In VivoExpression of mRNAs Encoding Hypoxia-Inducible Factor 1
1996 • 412 citations
Differential Effects of Physiologically Relevant Hypoxic Conditions on T Lymphocyte Development and Effector Functions
2001 • 396 citations
Aerobic glycolysis by proliferating cells: a protective strategy against reactive oxygen species 1
1997 • 392 citations
Cellular and Humoral immunity to Different Types of Human Neoplasms
1968 • 386 citations
The adenosine/neutrophil paradox resolved: human neutrophils possess both A1 and A2 receptors that promote chemotaxis and inhibit O2 generation, respectively.
1990 • 377 citations
Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung
1998 • 375 citations
Neutrophil adherence to endothelium is enhanced via adenosine A1 receptors and inhibited via adenosine A2 receptors.
1992 • 361 citations
Fundamental Immunology
2004 • 359 citations
Inhibition of TNF-alpha expression by adenosine: role of A3 adenosine receptors.
1996 • 345 citations
Adenosine; a physiologic modulator of superoxide anion generation by human neutrophils. Adenosine acts via an A2 receptor on human neutrophils.
1985 • 345 citations
The Mitochondrial Network of Human Neutrophils: Role in Chemotaxis, Phagocytosis, Respiratory Burst Activation, and Commitment to Apoptosis
2003 • 323 citations
Disruption of the A3 Adenosine Receptor Gene in Mice and Its Effect on Stimulated Inflammatory Cells
2000 • 303 citations
Integrated events in central dopamine transmission as analyzed at multiple levels. Evidence for intramembrane adenosine A2A/dopamine D2 and adenosine A1/dopamine D1 receptor interactions in the basal ganglia1Published on the World Wide Web on 12 January 1998.1
1998 • 281 citations
Heat Shock Proteins, Inflammation, and Cardiovascular Disease
2002 • 261 citations
Hypoxia-Induced Inhibition of Adenosine Kinase Potentiates Cardiac Adenosine Release
1997 • 257 citations
Role of Inflammatory Mediators in Thrombogenesis
2002 • 243 citations
Inflammatory Cytokines Regulate Function and Expression of Adenosine A2A Receptors in Human Monocytic THP-1 Cells
2001 • 231 citations
Adenosine affects expression of membrane molecules, cytokine and chemokine release, and the T-cell stimulatory capacity of human dendritic cells
2003 • 225 citations
Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells.
1999 • 218 citations
Hypoxic Preconditioning Induces Changes in HIF-1 Target Genes in Neonatal Rat Brain
2001 • 216 citations
Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice
2002 • 213 citations
Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor kappaB activation
2003 • 195 citations
IFN-gamma up-regulates the A2B adenosine receptor expression in macrophages: a mechanism of macrophage deactivation.
1999 • 192 citations
Adenosine A2AReceptors are Colocalized with and Activate Golfin Rat Striatum
2000 • 191 citations
Memory of Extracellular Adenosine A2A Purinergic Receptor-mediated Signaling in Murine T Cells
1997 • 188 citations
Stimulation of the Mitogen-activated Protein Kinase via the A2A-Adenosine Receptor in Primary Human Endothelial Cells
1997 • 187 citations
Expression and function of adenosine receptors in human dendritic cells
2001 • 186 citations
Evidence for Adenosine/Dopamine Receptor Interactions Indications for Heteromerization
2000 • 169 citations
Nucleotide Metabolism by Endothelium
1985 • 164 citations
Use of the A2A adenosine receptor as a physiological immunosuppressor and to engineer inflammation in vivo
2003 • 163 citations
Patterns of A2A extracellular adenosine receptor expression in different functional subsets of human peripheral T cells. Flow cytometry studies with anti-A2A receptor monoclonal antibodies.
1999 • 163 citations
Inflammation in acute coronary syndromes
2002 • 159 citations
Cyclic AMP‐dependent inhibition of human neutrophil oxidative activity by substituted 2‐propynylcyclohexyl adenosine A2A receptor agonists
2001 • 158 citations
IFN-γ Up-Regulates the A2B Adenosine Receptor Expression in Macrophages: A Mechanism of Macrophage Deactivation
1999 • 148 citations
Cytotoxic T Lymphocytes
1988 • 145 citations
The critical role of adenosine A2A receptors in downregulation of inflammation and immunity in the pathogenesis of infectious diseases
2003 • 143 citations
Protective effect of an adenosine kinase inhibitor in septic shock.
1994 • 138 citations
Pharmacology of Adenosine A2A Receptors and Therapeutic Applications
2003 • 135 citations
Chemotactic factor‐induced generation of superoxide radicals by human neutrophils
1979 • 122 citations
A3Adenosine Receptors in Human Neutrophils and Promyelocytic HL60 Cells: A Pharmacological and Biochemical Study
2002 • 121 citations
Activation of Mitogen-activated Protein Kinase by the A2A-adenosine Receptor via a rap1-dependent and via a p21 -dependent Pathway
1999 • 121 citations
Regional manifestations and control of the immune system
2002 • 120 citations
Adenosine A 2A Receptor Stimulation Reduces Inflammation and Neointimal Growth in a Murine Carotid Ligation Model
2001 • 117 citations
cAMP-elevating agents suppress dendritic cell function
2001 • 109 citations
Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling
2001 • 107 citations
The Role of Nitric Oxide (NO) in Stability Regulation of Hypoxia Inducible Factor-1&#945; (HIF-1&#945;)
2003 • 107 citations
Indoleamine 2,3-dioxygenase, immunosuppression and pregnancy
2002 • 101 citations
Induction and Direction of Immune Responses by Vaccine Adjuvants
2001 • 98 citations
Differential Regulation of Two Alternatively Spliced Isoforms of Hypoxia-inducible Factor-1α in Activated T Lymphocytes
2001 • 98 citations
Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling
2001 • 98 citations
Aggravated Brain Damage After Hypoxic Ischemia in Immature Adenosine A 2A Knockout Mice
2003 • 93 citations
Synthesis, Biological Activity, and Molecular Modeling Investigation of New Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine Derivatives as Human A3 Adenosine Receptor Antagonists
2002 • 93 citations
Human A2AAdenosine Receptors: High-Affinity Agonist Binding to Receptor-G Protein Complexes Containing Gβ4
2002 • 88 citations
Occupancy of adenosine receptors raises cyclic AMP alone and in synergy with occupancy of chemoattractant receptors and inhibits membrane depolarization
1988 • 85 citations
Neoceptor Concept Based on Molecular Complementarity in GPCRs: A Mutant Adenosine A3 Receptor with Selectively Enhanced Affinity for Amine-Modified Nucleosides
2001 • 82 citations
Analysis of A2a receptor-deficient mice reveals no significant compensatory increases in the expression of A2b, A1, and A3 adenosine receptors in lymphoid organs
2003 • 80 citations
Effects of extracellular ATP and adenosine on different thymocyte subsets: possible role of ATP-gated channels and G protein-coupled purinergic receptor.
1997 • 79 citations
Hypoxia in the thymus: role of oxygen tension in thymocyte survival
2002 • 74 citations
Effect of adenosine on the expression of β2 integrins and L-selectin of human polymorphonuclear leukocytes in vitro
1996 • 74 citations
Gene dose effect reveals no Gs-coupled A2A adenosine receptor reserve in murine T-lymphocytes: studies of cells from A2A-receptor-gene-deficient mice
2001 • 71 citations
Acting via A2 receptors, adenosine inhibits the production of tumor necrosis factor-alpha of endotoxin-stimulated human polymorphonuclear leukocytes.
1995 • 71 citations
Engagement of adenosine receptors inhibits hydrogen peroxide (H2O2−) release by activated human neutrophils
1987 • 70 citations
Effect of adenosine analogues and cAMP-raising agents on TNF-, GM-CSF–, and chemotactic peptide–induced degranulation in single adherent neutrophils
1992 • 63 citations
Recombinant human interleukin (IL)-1 beta-mediated regulation of hypoxia-inducible factor-1 alpha (HIF-1 alpha) stabilization, nuclear translocation and activation requires an antioxidant/reactive oxygen species (ROS)-sensitive mechanism.
2002 • 62 citations
Energy metabolism and T-cell-mediated cytolysis. I. Synergism between inhibitors of respiration and glycolysis.
1977 • 60 citations
Regulation of Coronary Blood Flow1
2015 • 59 citations
Adenosine and related compounds counteract tumor necrosis factor-alpha inhibition of neutrophil migration: implication of a novel cyclic AMP-independent action on the cell surface.
1990 • 59 citations
Adenosine production inside rat polymorphonuclear leucocytes
1981 • 59 citations
A2A receptor dependent and A2A receptor independent effects of extracellular adenosine on murine thymocytes in conditions of adenosine deaminase deficiency
2000 • 56 citations
The extracellular versus intracellular mechanisms of inhibition of TCR-triggered activation in thymocytes by adenosine under conditions of inhibited adenosine deaminase
1999 • 53 citations
Plasma adenosine levels increase in women with normal pregnancies
2000 • 50 citations
Inhibition of fMLP-triggered respiratory burst of human monocytes by adenosine: involvement of A3 adenosine receptor
1999 • 49 citations
Cyclic AMP has the ability to influence multiple events during B cell stimulation
1988 • 48 citations
Modulation of Leukocyte Behavior by an Inflamed Extracellular Matrix
2000 • 47 citations
In vivo labelling of the adenosine A2A receptor in mouse brain using the selective antagonist [3H]SCH 58261
2001 • 43 citations
Pentoxifylline does not act via adenosine receptors in the inhibition of the superoxide anion production of human polymorphonuclear leukocytes
1991 • 36 citations
Lymphocyte Membrane Adenosine Receptors Coupled to Adenylate Cyclase Properties and Occurrence in Various Lymphocyte Subclasses
1981 • 35 citations
In vitro, Candida albicans releases the immune modulator adenosine and a second, high-molecular weight agent that blocks neutrophil killing.
1992 • 34 citations
Effects of adenosine on the functions of circulating polymorphonuclear leukocytes during hyperdynamic endotoxemia
1997 • 33 citations
Study of A2A adenosine receptor gene deficient mice reveals that adenosine analogue CGS 21680 possesses no A2A receptor‐unrelated lymphotoxicity
2000 • 31 citations
Adenosine analogue reduces spinal cord reperfusion injury in a time-dependent fashion
2001 • 29 citations
Modulation of the chemotactic peptide- and immunoglobulin G-triggered respiratory burst in human neutrophils by exogenous and endogenous adenosine
1998 • 24 citations
Classification of adenosine receptors.
1984 • 20 citations
THE RESPIRATION AND ENERGY METABOLISM OF SHEEP LYMPHOCYTES
1984 • 14 citations
Relationship between adenosine deaminase activity and cytokine-secreting T cells in normal pregnancy
2002 • 14 citations
Increased ratio between anaerobic and aerobic metabolism in lymphocytes from hyperthyroid patients
1994 • 12 citations
Adenosine Deaminase-Deficient Mice: Models for the Study of Lymphocyte Development and Adenosine Signaling
2006 • 6 citations
Cited By (0)
No citing papers found in database