Integrated events in central dopamine transmission as analyzed at multiple levels. Evidence for intramembrane adenosine A2A/dopamine D2 and adenosine A1/dopamine D1 receptor interactions in the basal ganglia1Published on the World Wide Web on 12 January 1998.1

The organization of behavior

1988 • 8,668 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Adenosine–dopamine receptor–receptor interactions as an integrative mechanism in the basal ganglia

1997 • 804 citations

Recent Advances in the Molecular Biology of Dopamine Receptors

1993 • 768 citations

A Peptide Derived from a β2-Adrenergic Receptor Transmembrane Domain Inhibits Both Receptor Dimerization and Activation

1996 • 758 citations

Stimulation of high-affinity adenosine A2 receptors decreases the affinity of dopamine D2 receptors in rat striatal membranes.

1991 • 541 citations

Striatal Restricted Adenosine A₂ Receptor (RDC8) Is Expressed by Enkephalin but Not by Substance P Neurons: An In Situ Hybridization Histochemistry Study

1991 • 527 citations

Metabotropic Glutamate Receptor 5 Is a Disulfide-linked Dimer

1996 • 512 citations

Adenosine receptor subtypes

1993 • 418 citations

Signal transduction by allosteric receptor oligomerization

1988 • 410 citations

Adenosine-dopamine interactions in the brain

1992 • 366 citations

D.O. Hebb: The Organization of Behavior, Wiley: New York; 1949

1999 • 332 citations

Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular "cross-talk" between G-protein-linked receptors.

1993 • 321 citations

RDC8 codes for an adenosine A2 receptor with physiological constitutive activity

1990 • 270 citations

Dopamine D2 Receptor Dimers and Receptor-Blocking Peptides

1996 • 266 citations

The striopallidal neuron: a main locus for adenosine-dopamine interactions in the brain

1993 • 255 citations

Conversion of a gonadotropin-releasing hormone antagonist to an agonist

1982 • 174 citations

Purinoceptors in the Nervous System ^*

1995 • 174 citations

Antagonistic interaction between adenosine A2A receptors and dopamine D2 receptors in the ventral striopallidal system. Implications for the treatment of schizophrenia

1994 • 171 citations

Adenosine A2A Agonists: A Potential New Type of Atypical Antipsychotic

1997 • 155 citations

Receptor‐receptor interactions in the central nervous system. A new integrative mechanism in synapses

1985 • 155 citations

Modulation by cholecystokinins of ³H‐spiroperidol binding in rat striatum: evidence for increased affinity and reduction in the number of binding sites

1981 • 155 citations

Evidence for the existence of receptor--receptor interactions in the central nervous system. Studies on the regulation of monoamine receptors by neuropeptides.

1983 • 150 citations

Blockade of A_2a Adenosine Receptors Positively Modulates Turning Behaviour and c‐Fos Expression Induced by D₁ Agonists in Dopamine‐denervated Rats

1996 • 145 citations

Dopamine D₁ Receptor‐mediated Facilitation of GABAergic Neurotransmission in the Rat Strioentopeduncular Pathway and its Modulation by Adenosine A₁ Receptor‐mediated Mechanisms

1996 • 142 citations

Postsynaptic antagonistic interaction between adenosine A1, and dopamine D1 receptors

1994 • 138 citations

Receptor-receptor interactions as an integrative mechanism in nerve cells

1993 • 132 citations

Neurotensin in vitro markedly reduces the affinity in subcortical limbic ³H‐N‐propylnorapomorphine binding sites*

1983 • 128 citations

Aspects on receptor regulation and isoreceptor identification.

1980 • 126 citations

beta-FNA binds irreversibly to the opiate receptor complex: in vivo and in vitro evidence.

1988 • 123 citations

Postsynaptic dopamine/adenosine interaction: I. Adenosine analogues inhibit dopamine D2-mediated behaviour in short-term reserpinized mice

1991 • 118 citations

Effects of adenosine A1 and A2 receptor activation on electrically evoked dopamine and acetylcholine release from rat striatal slices.

1993 • 115 citations

Adenosine A1 Receptor-mediated Modulation of Dopamine D1 Receptors in Stably Cotransfected Fibroblast Cells

1998 • 113 citations

Opposing actions of adenosine A2a and dopamine D2 receptor activation on GABA release in the basal ganglia: Evidence for an A2a/D2 receptor interaction in globus pallidus

1996 • 110 citations

CNS Neurotransmitters and Neuromodulators: Dopamine

1996 • 105 citations

Dopamine denervation leads to an increase in the intramembrane interaction between adenosine A2 and dopamine D2 receptors in the neostriatum

1992 • 104 citations

Functional Role of the Third Cytoplasmic Loop in Muscarinic Receptor Dimerization

1996 • 98 citations

Desensitisation of the Adenosine A₁ Receptor by the A_2A Receptor in the Rat Striatum

1997 • 98 citations

Adenosine A2A receptors modulate the binding characteristics of dopamine D2 receptors in stably cotransfected fibroblast cells

1996 • 97 citations

Intramembrane Interactions between Neurotensin Receptors and Dopamine D₂ Receptors as a Major Mechanism for the Neuroleptic‐like Action of Neurotensina

1992 • 93 citations

Evidence for a substrate of neuronal plasticity based on pre- and postsynaptic neurotensin-dopamine receptor interactions in the neostriatum.

1992 • 79 citations

Adenosine A1 receptor blockade selectively potentiates the motor effects induced by dopamine D1 receptor stimulation in rodents

1996 • 73 citations

Adenosine A2 receptors stimulate c-fos expression in striatal neurons of 6-hydroxydopamine-lesioned rats

1995 • 69 citations

Neurotensin reduces the affinity of D‐2 dopamine receptors in rat striatal membranes

1987 • 65 citations

Adenosine A2 receptor regulation of apomorphine-induced turning in rats with unilateral striatal dopamine denervation

1993 • 59 citations

Opposing actions of an adenosine A2 receptor agonist and a GTP analogue on the regulation of dopamine D2 receptors in rat neostriatal membranes

1993 • 58 citations

Neuroleptics Up‐Regulate Adenosine A_2a Receptors in Rat Striatum: Implications for the Mechanism and the Treatment of Tardive Dyskinesia

1995 • 55 citations

Antagonistic A_2a/D₂ receptor interactions in the striatum as a basis for adenosine/dopamine interactions in the central nervous system

1993 • 53 citations

Structure‐activity relationships for transmembrane signaling: the receptor's turn

1991 • 48 citations

Receptor-Receptor Interactions

1987 • 46 citations

Reduction of dopamine D2 receptor transduction by activation of adenosine A2a receptors in stablyA2a/D2 (long-form) receptor co-transfected mouse fibroblast cell lines: Studies on intracellular calcium levels

1995 • 39 citations

The Behavioural Pharmacology of Typical and Atypical Antipsychotic Drugs

1996 • 36 citations

Chronic haloperidol treatment leads to an increase in the intramembrane interaction between adenosine A2 and dopamine D2 receptors in the neostriatum

1994 • 31 citations

Subcortical limbic 3H-N-propylnorapomorphine binding sites are markedly modulated by cholecystokinin-8 in vitro

1983 • 31 citations

Receptor‐Receptor Interactions and Their Relevance for Receptor Diversity

1995 • 31 citations

Cholecystokinin OctapeptideIn VitroandEx VivoStrongly Modulates Striatal Dopamine D₂Receptors in Rat Forebrain Sections

1995 • 31 citations

Intramembrane receptor-receptor interactions: integration of signal transduction pathways in the nervous system

1993 • 27 citations

Possible Mechanisms for the Powerful Actions of Neuropeptides^a

1994 • 25 citations

Adenosine A2 receptor-mediated modulation of contralateral rotation induced by metabotropic glutamate receptor activation

1995 • 24 citations

Receptor-receptor interactions : a new intramembrane integrative mechanism : proceedings of an international symposium held at the Wenner-Gren Center, Stockholm, October 9th-11th, 1986

1987 • 23 citations

A brief appraisal on some aspects of the receptor-receptor interaction

1995 • 23 citations

Modulation of Dopamine D1 and D2 Transmission Lines in the Central Nervous System

1990 • 22 citations

Neuropeptides, excitatory amino acid and adenosine A2 receptors regulate D2 receptors via intramembrane receptor-receptor interactions. Relevance for Parkinson's disease and schizophrenia

1992 • 22 citations

THE RECEPTOR MOSAIC HYPOTHESIS OF THE ENGRAM: POSSIBLE RELEVANCE OF BOOLEAN NETWORK MODELING

1996 • 21 citations

Stimulation of adenosine A1 receptors prevents the EEG arousal due to dopamine D1 receptor activation in rabbits

1996 • 21 citations

Modulation of [3H]quinpirole binding to dopaminergic receptors by adenosine A2A receptors

1997 • 17 citations

beta-Adrenergic receptor isolation and characterization with immobilized drugs and monoclonal antibodies.

1983 • 15 citations

A2a/D2 receptor interactions are not observed in COS-7 cells transiently transfected with dopamine D2 and adenosine A2a receptor cDNA

1994 • 13 citations

Evidence for the Existence of Antagonistic Intramembrane Adenosine A2a/dopamine D2 Receptor Interactions in the Basal Ganglia: Analysis from the Network to the Molecular Level

1995 • 5 citations