Modulation of the chemotactic peptide- and immunoglobulin G-triggered respiratory burst in human neutrophils by exogenous and endogenous adenosine

Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

1968 • 5,084 citations

Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.

1990 • 1,507 citations

The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.

1993 • 658 citations

Adenosine, an endogenous anti-inflammatory agent

1994 • 635 citations

Leukocytes and the Risk of Ischemic Diseases

1987 • 525 citations

The Role of Adenosine and 2'-Deoxyadenosine in Mammalian Cells

1978 • 518 citations

Free radicals and phagocytic cells

1995 • 487 citations

Topics and Perspectives in Adenosine Research

1987 • 459 citations

Adenosine: an endogenous inhibitor of neutrophil-mediated injury to endothelial cells.

1986 • 416 citations

The adenosine/neutrophil paradox resolved: human neutrophils possess both A1 and A2 receptors that promote chemotaxis and inhibit O2 generation, respectively.

1990 • 377 citations

Neutrophil adherence to endothelium is enhanced via adenosine A1 receptors and inhibited via adenosine A2 receptors.

1992 • 361 citations

Adenosine; a physiologic modulator of superoxide anion generation by human neutrophils. Adenosine acts via an A2 receptor on human neutrophils.

1985 • 345 citations

Clinical significance of IgG Fc receptors and FcγR-directed immunotherapies

1997 • 221 citations

The anti-inflammatory mechanism of sulfasalazine is related to adenosine release at inflamed sites.

1996 • 199 citations

Adenosine receptors.

1992 • 196 citations

Adenosine transporters

1996 • 188 citations

Adenosine Acts as an Endogenous Activator of the Cellular Antioxidant Defense System

1994 • 160 citations

The Genetic Basis of Chronic Granulomatous Disease

1994 • 139 citations

Fc gamma receptor-mediated functions in neutrophils are modulated by adenosine receptor occupancy. A1 receptors are stimulatory and A2 receptors are inhibitory.

1990 • 126 citations

Rap1A is a substrate for cyclic AMP-dependent protein kinase in human neutrophils.

1991 • 119 citations

Adenosine A2A receptors mediate the inhibitory effect of adenosine on formyl-Met-Leu-Phe-stimulated respiratory burst in neutrophil leucocytes

1996 • 112 citations

Reciprocal interactions between protein kinase C and components of the NADPH oxidase complex may regulate superoxide production by neutrophils stimulated with a phorbol ester.

1994 • 109 citations

Leukocytes and the risk of ischemic diseases

1987 • 109 citations

Diacylglycerol accumulation and superoxide anion production in stimulated human neutrophils.

1987 • 103 citations

Adenosine A2 Receptor Occupancy Regulates Stimulated Neutrophil Function via Activation of a Serine/Threonine Protein Phosphatase

1996 • 97 citations

Purines and neutrophil leukocytes

1997 • 94 citations

Protein Kinase A Downregulates the Phosphorylation of p47 Phox in Human Neutrophils: A Possible Pathway for Inhibition of the Respiratory Burst

1996 • 89 citations

Occupancy of adenosine receptors raises cyclic AMP alone and in synergy with occupancy of chemoattractant receptors and inhibits membrane depolarization

1988 • 85 citations

Cyclic AMP-elevating agents block chemoattractant activation of diradylglycerol generation by inhibiting phospholipase D activation

1991 • 78 citations

Anti-inflammatory effects of an adenosine kinase inhibitor. Decreased neutrophil accumulation and vascular leakage.

1995 • 75 citations

Engagement of adenosine receptors inhibits hydrogen peroxide (H2O2−) release by activated human neutrophils

1987 • 70 citations

Cyclic AMP-increasing Agents Interfere with Chemoattractant-induced Respiratory Burst in Neutrophils as a Result of the Inhibition of Phosphatidylinositol 3-Kinase Rather than Receptor-operated Ca2+ Influx

1995 • 69 citations

Release of oxygen metabolites from chemoattractant-stimulated neutrophils is inhibited by resting platelets: role of extracellular adenosine and actin polymerization

1996 • 67 citations

A novel approach to the development of anti-inflammatory agents: adenosine release at inflamed sites.

1995 • 65 citations

Adenosine inhibits the rise in intracellular calcium and platelet aggregation produced by thrombin: evidence that both effects are coupled to adenylate cyclase.

1990 • 58 citations

Occupancy of G alpha s-linked receptors uncouples chemoattractant receptors from their stimulus-transduction mechanisms in the neutrophil

1992 • 55 citations

Platelets enhance Fcγ receptor-mediated phagocytosis and respiratory burst in neutrophils: the role of purinergic modulation and actin polymerization

1996 • 55 citations

The role of cyclic AMP, calcium and filamentous actin in adenosine modulation of Fc receptor-mediated phagocytosis in human neutrophils

1994 • 47 citations

The interaction of inhibitors with adenosine metabolising enzymes in intact isolated cells

1981 • 46 citations

Purine catabolism in polymorphonuclear neutrophils. Phorbol myristate acetate-induced accumulation of adenosine owing to inactivation of extracellularly released adenosine deaminase.

1991 • 45 citations

Anti-inflammatory effects of adenosine kinase inhibitors in acute and chronic inflammation

1996 • 44 citations

Adenosine inhibits actin dynamics in human neutrophils: Evidence for the involvement of cAMP

1998 • 44 citations

Effect of Cyclic AMP Level Reduction on Human Neutrophil Responses to Formylated Peptides

1996 • 44 citations

Dual Action of cAMP-Dependent Protein Kinase on Granulocyte Movement

1997 • 36 citations

Stimulus-response uncoupling in the neutrophil. Adenosine A2-receptor occupancy inhibits the sustained, but not the early, events of stimulus transduction in human neutrophils by a mechanism independent of actin-filament formation

1992 • 35 citations

Effects of adenosine on polymorphonuclear leucocyte function, cyclic 3′:5′‐adenosine monophosphate, and intracellular calcium

1989 • 34 citations

Adenosine inhibits fMLP-stimulated adherence and superoxide anion generation by human neutrophils at an early step in signal transduction

1993 • 33 citations

Coupling of antagonistic signalling pathways in modulation of neutrophil function

1989 • 30 citations

Effects of Adenosine on Inositol 1,4,5-Trisphosphate Formation and Intracellular Calcium Changes in Formyl-Met-Leu-Phe-Stimulated Human Neutrophils

1990 • 27 citations

Purine and Pyrimidine Metabolism in Man VIII

1994 • 26 citations

Effects of cyclic nucleotides on granulocytes.

1992 • 24 citations

Occupancy of adenosine receptors on human neutrophils inhibits respiratory burst stimulated by ingestion of complement-coated particles and occupancy of chemoattractant but not Fc receptors

1989 • 18 citations

Reversal of inhibitory pathways in neutrophils by protein kinase antagonists: a rational approach to the restoration of depressed cell function?

1992 • 16 citations

Effects of Adenosine on Human Neutrophil Function and Cyclic AMP Content

1987 • 13 citations

Adenosine, a cytoprotective autocoid: effects of adenosine on neutrophil plasma membrane viscosity and chemoattractant receptor display

1989 • 13 citations

Adenosine and adenosine receptors in immune function. Minireview and meeting report

1987 • 12 citations

An inhibitor of cyclic AMP-dependent protein kinase enhances the superoxide production of human neutrophils stimulated by N-formyl-methionyl-leucyl-phenylalanine

1995 • 12 citations

Endogenous Adenosine Formation can Regulate Human Neutrophil Function

1995 • 5 citations

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