Feedback control of the protein kinase TAK1 by SAPK2a/p38

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 4,109 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

2001 • 2,027 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

1995 • 1,318 citations

Organization and regulation of mitogen-activated protein kinase signaling pathways

1999 • 1,288 citations

The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway

1999 • 1,163 citations

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activationofCREB

1998 • 975 citations

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

1999 • 970 citations

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1997 • 927 citations

Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA.

1988 • 897 citations

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

1997 • 770 citations

TAB2, a Novel Adaptor Protein, Mediates Activation of TAK1 MAPKKK by Linking TAK1 to TRAF6 in the IL-1 Signal Transduction Pathway

2000 • 589 citations

TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal Transduction

1996 • 582 citations

The search for physiological substrates of MAP and SAP kinases in mammalian cells

1997 • 544 citations

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

2001 • 525 citations

Essential Role of p38α MAP Kinase in Placental but Not Embryonic Cardiovascular Development

2000 • 509 citations

MAPKK-Independent Activation of p38α Mediated by TAB1-Dependent Autophosphorylation of p38α

2002 • 507 citations

MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase.

1992 • 486 citations

Mechanism of p38 MAP kinase activation in vivo

2003 • 466 citations

Identification of Mitogen-activated Protein (MAP) Kinase-activated Protein Kinase-3, a Novel Substrate of CSBP p38 MAP Kinase

1996 • 346 citations

Phosphorylation Sites on Tau Identified by Nanoelectrospray Mass Spectrometry

2000 • 343 citations

The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts.

1993 • 305 citations

The Nature of the 660-Kilometer Upper-Mantle Seismic Discontinuity from Precursors to the PP Phase

1996 • 245 citations

Cross-talk between ERK and p38 MAPK Mediates Selective Suppression of Pro-inflammatory Cytokines by Transforming Growth Factor-β

2002 • 234 citations

A 3-Phosphoinositide-dependent Protein Kinase-1 (PDK1) Docking Site Is Required for the Phosphorylation of Protein Kinase Cζ (PKCζ) and PKC-related Kinase 2 by PDK1

2000 • 185 citations

TAK1 regulates multiple protein kinase cascades activated by bacterial lipopolysaccharide

2000 • 177 citations

[29] Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf

1995 • 163 citations

p38 MAPK enhances STAT1-dependent transcription independently of Ser-727 phosphorylation

2002 • 125 citations

Differential Activation of p38 Mitogen-activated Protein Kinase Isoforms Depending on Signal Strength

2000 • 98 citations

Stimulus-specific Requirements for MAP3 Kinases in Activating the JNK Pathway

2002 • 91 citations

Negative Feedback Regulation of MKK6 mRNA Stability by p38α Mitogen-Activated Protein Kinase

2002 • 72 citations

Inhibition of the p38 pathway upregulates macrophage JNK and ERK activities, and the ERK, JNK, and p38 MAP kinase pathways are reprogrammed during differentiation of the murine myeloid M1 cell line

2002 • 34 citations