IAP Suppression of Apoptosis Involves Distinct Mechanisms: the TAK1/JNK1 Signaling Cascade and Caspase Inhibition

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

1997 • 3,167 citations

IAP family proteins---suppressors of apoptosis

1999 • 2,570 citations

X-linked IAP is a direct inhibitor of cell-death proteases

1997 • 1,961 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development

1998 • 1,551 citations

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

1998 • 1,394 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

1995 • 1,318 citations

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

1997 • 1,316 citations

IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs.

1998 • 1,243 citations

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

1995 • 1,237 citations

Aberrant rel/nfkb genes and activity in human cancer

1999 • 1,127 citations

Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

1996 • 1,027 citations

Ubiquitin Protein Ligase Activity of IAPs and Their Degradation in Proteasomes in Response to Apoptotic Stimuli

2000 • 989 citations

Dysregulation of Apoptosis in Cancer

1999 • 983 citations

The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy

1995 • 976 citations

Apoptosis signaling by death receptors

1998 • 976 citations

Mitochondria and cell death

1999 • 763 citations

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

1999 • 750 citations

Role of Bcl‐2 family proteins in apoptosis: apoptosomes or mitochondria?

1998 • 705 citations

An Anti-apoptotic Protein Human Survivin Is a Direct Inhibitor of Caspase-3 and -7

2001 • 670 citations

Nuclear Factor (NF)-κB–regulated X-chromosome–linked iap Gene Expression Protects Endothelial Cells from Tumor Necrosis Factor α–induced Apoptosis

1998 • 643 citations

A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors.

1996 • 637 citations

Escaping Cell Death: Survival Proteins in Cancer

1999 • 629 citations

A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases

1998 • 611 citations

TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal Transduction

1996 • 582 citations

Control of Programmed Cell Death by the Baculovirus Genes p35 and iap

1994 • 517 citations

Diverse functions of JNK signaling and c-Jun in stress response and apoptosis

1999 • 516 citations

Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.

1996 • 515 citations

JNK and p38 stresskinases — degenerative effectors of signal-transduction-cascades in the nervous system

2000 • 490 citations

Roles of Nuclear Factor κB in Neuronal Survival and Plasticity

2000 • 465 citations

Livin, a Novel Inhibitor of Apoptosis Protein Family Member

2001 • 453 citations

A Novel Kinase Cascade Mediated by Mitogen-activated Protein Kinase Kinase 6 and MKK3

1996 • 443 citations

ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas

2000 • 407 citations

XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway

1999 • 388 citations

Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH ₂ -terminal kinase

1997 • 382 citations

The IκB/NF-κB system: a key determinant of mucosal inflammation and protection

2000 • 377 citations

Mechanisms of apoptosis avoidance in cancer

1999 • 371 citations

The Rel/NF-κB family: friend and foe

2000 • 368 citations

Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2

1999 • 357 citations

An exegesis of IAPs: salvation and surprises from BIR motifs

1999 • 345 citations

The IAP family: endogenous caspase inhibitors with multiple biological activities

2000 • 296 citations

Review: Nuclear Events in Apoptosis

2000 • 283 citations

Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation

1999 • 251 citations

A Giant Ubiquitin-conjugating Enzyme Related to IAP Apoptosis Inhibitors

1998 • 248 citations

c-Jun and the transcriptional control of neuronal apoptosis

2000 • 241 citations

Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death

2000 • 233 citations

Activation of NF-κB by XIAP, the X Chromosome-linked Inhibitor of Apoptosis, in Endothelial Cells Involves TAK1

2000 • 227 citations

Human IAP-Like Protein Regulates Programmed Cell Death Downstream of Bcl-x_L and Cytochrome c

1998 • 216 citations

Loss of caspase-1 and caspase-3 protein expression in human prostate cancer.

2001 • 200 citations

Activation of the Hematopoietic Progenitor Kinase-1 (HPK1)-dependent, Stress-activated c-Jun N-terminal Kinase (JNK) Pathway by Transforming Growth Factor β (TGF-β)-activated Kinase (TAK1), a Kinase Mediator of TGF β Signal Transduction

1997 • 193 citations

The c-Jun N-terminal kinase pathway and apoptotic signaling (review).

2000 • 189 citations

MKK7 Is A Stress-activated Mitogen-activated Protein Kinase Kinase Functionally Related to hemipterous

1997 • 182 citations

TAK1 regulates multiple protein kinase cascades activated by bacterial lipopolysaccharide

2000 • 177 citations

Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy (review).

1998 • 158 citations

Selective activation of JNK1 is necessary for the anti-apoptotic activity of hILP

1998 • 134 citations

Adenovirus‐Mediated Gene Transfer of Inhibitors of Apoptosis Proteins Delays Apoptosis in Cerebellar Granule Neurons

1999 • 129 citations

NAIP interacts with hippocalcin and protects neurons against calcium-induced cell death through caspase-3-dependent and -independent pathways

2000 • 129 citations

Evolutionary conservation of apoptosis mechanisms: Lepidopteran and baculoviral inhibitor of apoptosis proteins are inhibitors of mammalian caspase-9

2000 • 127 citations

KIAP, a Novel Member of the Inhibitor of Apoptosis Protein Family

2000 • 121 citations

Intranuclear huntingtin increases the expression of caspase-1 and induces apoptosis

2000 • 120 citations

Evidence for Multiple Activators for Stress-activated Protein Kinases/c-Jun Amino-terminal Kinases.

1995 • 114 citations

TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily.

1994 • 82 citations

Apoptosis and cell division

2000 • 75 citations

The neuronal apoptosis inhibitory protein suppresses neuronal differentiation and apoptosis in PC12 cells

2000 • 64 citations

Selective expression of JNK isoforms and stress-specific JNK activity in different neural cell lines

2000 • 59 citations

Differential phosphorylation of mitogen-activated protein kinase families by epidermal growth factor and ultraviolet B irradiation in SV40-transformed human keratinocytes

2001 • 28 citations

Silencing of the caspase-1 gene occurs in murine and human renal cancer cells and causes solid tumor growthin vivo

2001 • 26 citations

Cloning of the gene encoding the murine orphan receptor TAK1 and cell-type-specific expression in testis

1995 • 18 citations

Purification and Use of Recombinant Inhibitor of Apoptosis Proteins as Caspase Inhibitors

2000 • 15 citations