Toll/IL-1 Receptor Domain-Containing Adaptor Inducing IFN-β (TRIF) Associates with TNF Receptor-Associated Factor 6 and TANK-Binding Kinase 1, and Activates Two Distinct Transcription Factors, NF-κB and IFN-Regulatory Factor-3, in the Toll-Like Receptor Signaling

Innate Immune Recognition

2002 • 8,157 citations

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

2001 • 5,893 citations

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

2003 • 3,104 citations

Toll-like receptors in the induction of the innate immune response

2000 • 3,052 citations

IKKε and TBK1 are essential components of the IRF3 signaling pathway

2003 • 2,536 citations

Unresponsiveness of MyD88-Deficient Mice to Endotoxin

1999 • 2,088 citations

Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function

1998 • 2,047 citations

Triggering the Interferon Antiviral Response Through an IKK-Related Pathway

2003 • 1,625 citations

Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene Induction

2000 • 1,304 citations

Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling

2002 • 1,228 citations

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction

2003 • 1,203 citations

Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes

2001 • 1,078 citations

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4

2002 • 985 citations

IRF3 Mediates a TLR3/TLR4-Specific Antiviral Gene Program

2002 • 844 citations

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

2002 • 803 citations

Distinct molecular mechanism for initiating TRAF6 signalling

2002 • 642 citations

NF-kappa B activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase

1999 • 554 citations

Endotoxin-Induced Maturation of MyD88-Deficient Dendritic Cells

2001 • 505 citations

IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IκB kinases

1999 • 362 citations

Poly(dI·dC)-induced Toll-like Receptor 3 (TLR3)-mediated Activation of NFκB and MAP Kinase Is through an Interleukin-1 Receptor-associated Kinase (IRAK)-independent Pathway Employing the Signaling Components TLR3-TRAF6-TAK1-TAB2-PKR

2003 • 300 citations

Association of the Adaptor TANK with the IκB Kinase (IKK) Regulator NEMO Connects IKK Complexes with IKKε and TBK1 Kinases

2002 • 152 citations

NF‐κB activation through IKK‐i‐dependent I‐TRAF/TANK phosphorylation

2000 • 101 citations