Rac Activation by Lysophosphatidic Acid LPA1Receptors through the Guanine Nucleotide Exchange Factor Tiam1

Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement

1999 • 1,452 citations

Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

2002 • 1,225 citations

Rac Downregulates Rho Activity

1999 • 840 citations

Episomal Vectors Rapidly and Stably Produce High-Titer Recombinant Retrovirus

1996 • 768 citations

Direct Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by Gα ₁₃

1998 • 765 citations

Matrix-dependent Tiam1/Rac Signaling in Epithelial Cells Promotes Either Cell–Cell Adhesion or Cell Migration and Is Regulated by Phosphatidylinositol 3-Kinase

1998 • 667 citations

The bioactive phospholipid lysophosphatidic acid is released from activated platelets

1993 • 653 citations

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

1994 • 617 citations

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins

1994 • 518 citations

RhoA is required for monocyte tail retraction during transendothelial migration

2001 • 498 citations

Lysophosphatidic acid: G-protein signalling and cellular responses

1997 • 492 citations

Molecular Dissection of the Rho-associated Protein Kinase (p160ROCK)-regulated Neurite Remodeling in Neuroblastoma N1E-115 Cells

1998 • 465 citations

International Union of Pharmacology. XXXIV. Lysophospholipid Receptor Nomenclature

2002 • 462 citations

P-Rex1, a PtdIns(3,4,5)P3- and Gβγ-Regulated Guanine-Nucleotide Exchange Factor for Rac

2002 • 460 citations

Inhibition of Invasion of Epithelial Cells by Tiam1-Rac Signaling

1997 • 448 citations

Bioactive Lysophospholipids and Their G Protein-Coupled Receptors

1999 • 412 citations

Lysophosphatidic Acid Receptors

2000 • 404 citations

Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours

2002 • 388 citations

A Novel PDZ Domain Containing Guanine Nucleotide Exchange Factor Links Heterotrimeric G Proteins to Rho

1999 • 386 citations

The Guanine Nucleotide Exchange Factor Tiam1 Affects Neuronal Morphology; Opposing Roles for the Small GTPases Rac and Rho

1997 • 360 citations

Characterization of an ovarian cancer activating factor in ascites from ovarian cancer patients.

1995 • 325 citations

Activation of RhoA by Lysophosphatidic Acid and Gα_12/13Subunits in Neuronal Cells: Induction of Neurite Retraction

1999 • 303 citations

Oncogenic Ras Downregulates Rac Activity, Which Leads to Increased Rho Activity and Epithelial–Mesenchymal Transition

2000 • 290 citations

A single receptor encoded by vzg-1 / lp _A1 / edg- 2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid

1998 • 280 citations

Multiple Mechanisms Linked to Platelet Activation Result in Lysophosphatidic Acid and Sphingosine 1-Phosphate Generation in Blood

2002 • 254 citations

Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing

2000 • 238 citations

Leukemia‐associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G₁₂ family to Rho

2000 • 224 citations

Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling

1998 • 223 citations

Roles of Non-catalytic Subunits in Gβγ-induced Activation of Class I Phosphoinositide 3-Kinase Isoforms β and γ

1999 • 220 citations

Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading

1999 • 214 citations

A Novel Role for Phosphatidylinositol 3-Kinase β in Signaling from G Protein-coupled Receptors to Akt

2000 • 195 citations

Heterotrimeric G-protein βγ-dimers in growth and differentiation

2001 • 194 citations

Induction of in Vitro Tumor Cell Invasion of Cellular Monolayers by Lysophosphatidic Acid or Phospholipase D

1993 • 185 citations

Malignant effusions contain lysophosphatidic acid (LPA)-like activity

1998 • 178 citations

Lysophosphatidic Acid (LPA) Is a Novel Extracellular Regulator of Cortical Neuroblast Morphology

2000 • 170 citations

Dynamin Is Required for the Activation of Mitogen-activated Protein (MAP) Kinase by MAP Kinase Kinase

1999 • 165 citations

Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists

2001 • 163 citations

Alpha2-adrenergic receptor-mediated release of lysophosphatidic acid by adipocytes. A paracrine signal for preadipocyte growth.

1998 • 134 citations

A Function for Phosphatidylinositol 3-Kinase β (p85α-p110β) in Fibroblasts during Mitogenesis: Requirement for Insulin- and Lysophosphatidic Acid-Mediated Signal Transduction

1998 • 129 citations

Modulation of intestinal epithelial wound healing in vitro and in vivo by lysophosphatidic acid

1999 • 119 citations

Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components

2000 • 116 citations

Translocation of the Rac1 Guanine Nucleotide Exchange Factor Tiam1 Induced by Platelet-derived Growth Factor and Lysophosphatidic Acid

2000 • 90 citations

Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components

2000 • 80 citations

Lysophosphatidic acid is a chemoattractant for Dictyostelium discoideum amoebae.

1993 • 70 citations