Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

A causal role for E-cadherin in the transition from adenoma to carcinoma

1998 • 1,415 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

1986 • 865 citations

Rac Downregulates Rho Activity

1999 • 840 citations

Ras and Rho GTPases

2000 • 779 citations

The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

1997 • 772 citations

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K

1997 • 746 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

Matrix-dependent Tiam1/Rac Signaling in Epithelial Cells Promotes Either Cell–Cell Adhesion or Cell Migration and Is Regulated by Phosphatidylinositol 3-Kinase

1998 • 667 citations

Activation of Phosphoinositide 3-OH Kinase by the α6β4 Integrin Promotes Carcinoma Invasion

1997 • 615 citations

A role for Rac in Tiaml-induced membrane ruffling and invasion

1995 • 562 citations

Regulation of Cell–Cell Adhesion by Rac and Rho Small G Proteins in MDCK Cells

1997 • 555 citations

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins

1994 • 518 citations

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1

1998 • 468 citations

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors

1993 • 465 citations

Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras

1997 • 451 citations

Inhibition of Invasion of Epithelial Cells by Tiam1-Rac Signaling

1997 • 448 citations

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

2000 • 356 citations

The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis

1998 • 308 citations

Oncogenic Ras Downregulates Rac Activity, Which Leads to Increased Rho Activity and Epithelial–Mesenchymal Transition

2000 • 290 citations

The E-cadherin/Catenin Complex in Invasion and Metastasis

1996 • 227 citations

Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo

1998 • 220 citations

Suppression of Ras-Induced Apoptosis by the Rac GTPase

1999 • 177 citations

Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7.

1991 • 116 citations

Integration of positive and negative growth signals during ras pathway activation in vivo

2000 • 97 citations

Expression ofTiam-1in the Developing Brain Suggests a Role for the Tiam-1–Rac Signaling Pathway in Cell Migration and Neurite Outgrowth

1997 • 95 citations

High levels of phosphorylated c-Jun, Fra-1, Fra-2 and ATF-2 proteins correlate with malignant phenotypes in the multistage mouse skin carcinogenesis model

2000 • 87 citations