Phospholipase Cγ2 Provides Survival Signals via Bcl2 and A1 in Different Subpopulations of B Cells

The biochemistry of apoptosis

2000 • 7,314 citations

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

1991 • 1,783 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

B Cell Development Pathways

2001 • 1,185 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death

1997 • 1,091 citations

Regulation of Phosphoinositide-specific Phospholipase C Isozymes

1997 • 866 citations

B Cell Development in the Spleen Takes Place in Discrete Steps and Is Determined by the Quality of B Cell Receptor–Derived Signals

1999 • 843 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

Defective B cell development and function in Btk-deficient mice

1995 • 729 citations

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1995 • 726 citations

Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens

1991 • 694 citations

Defective Lymphoid Development in Mice Lacking Jak3

1995 • 650 citations

Impaired B Cell Development and Proliferation in Absence of Phosphoinositide 3-Kinase p85α

1999 • 642 citations

Syk tyrosine kinase required for mouse viability and B-cell development

1995 • 632 citations

The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver.

1993 • 573 citations

Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency

1986 • 558 citations

Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3

1995 • 551 citations

Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice

1995 • 475 citations

Phospholipase Cγ2 Is Essential in the Functions of B Cell and Several Fc Receptors

2000 • 473 citations

Xid -Like Immunodeficiency in Mice with Disruption of the p85α Subunit of Phosphoinositide 3-Kinase

1999 • 465 citations

Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires.

1996 • 451 citations

Characterization of the B Lymphocyte Populations in Lyn-Deficient Mice and the Role of Lyn in Signal Initiation and Down-Regulation

1997 • 451 citations

GENETIC ANALYSIS OF B CELL ANTIGEN RECEPTOR SIGNALING

1999 • 432 citations

Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses

1997 • 417 citations

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

1999 • 410 citations

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia.

1994 • 396 citations

B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40

1993 • 390 citations

B1 cells: similarities and differences with other B cell subsets

2001 • 387 citations

Antigen-induced B-cell death and elimination during germinal-centre immune responses

1995 • 377 citations

Targeted disruption of µ chain membrane exon causes loss of heavy-chain allelic exclusion

1992 • 376 citations

Positive Selection from Newly Formed to Marginal Zone B Cells Depends on the Rate of Clonal Production, CD19, and btk

2000 • 349 citations

Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2.

1993 • 336 citations

Abnormal Development and Function of B Lymphocytes in Mice Deficient for the Signaling Adaptor Protein SLP-65

1999 • 321 citations

POSITIVE VERSUS NEGATIVE SIGNALING BY LYMPHOCYTE ANTIGEN RECEPTORS

1998 • 320 citations

Impaired expansion of mouse B cell progenitors lacking Btk

1995 • 314 citations

Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes.

1994 • 305 citations

Soluble antigen can cause enhanced apoptosis of germinal-centre B cells

1995 • 301 citations

Requirement for B Cell Linker Protein (BLNK) in B Cell Development

1999 • 298 citations

NF-κB RelA-deficient Lymphocytes: Normal Development of T Cells and B Cells, Impaired Production of IgA and IgG1 and Reduced Proliferative Responses

1997 • 296 citations

Aberrant B Cell Development and Immune Response in Mice with a Compromised BCR Complex

1996 • 290 citations

Anti‐immunoglobulin antibodies induce apoptosis in immature B cell lymphomas

1990 • 253 citations

Anti‐immunoglobulins induce death by apoptosis in WEHI‐231 B lymphoma cells

1990 • 239 citations

Transitional B Lymphocyte Subsets Operate as Distinct Checkpoints in Murine Splenic B Cell Development

2002 • 228 citations

Requirement of phospholipase C-gamma 2 activation in surface immunoglobulin M-induced B cell apoptosis.

1995 • 199 citations

Bcl-2 expression promotes B- but not T-lymphoid development in scid mice

1994 • 157 citations

Development and follicular localization of tolerant B lymphocytes in lysozyme/anti-lysozyme lgM/lgD transgenic mice

1992 • 147 citations

Restoration of lymphocyte function in Janus Kinase 3-deficient mice by retroviral-mediated gene transfer

1998 • 143 citations

B Cell Antigen Receptor-Induced Activation of Akt Promotes B Cell Survival and Is Dependent on Syk Kinase

2000 • 143 citations

TRANSCRIPTIONAL REGULATION DURING B CELL DEVELOPMENT

1998 • 141 citations

Predominant expression and activation-induced tyrosine phosphorylation of phospholipase C-gamma 2 in B lymphocytes.

1992 • 131 citations

An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis.

1996 • 117 citations

The Adaptor Protein BLNK Is Required for B Cell Antigen Receptor-induced Activation of Nuclear Factor-κB and Cell Cycle Entry and Survival of B Lymphocytes

2001 • 103 citations

Long-Lived B Cells Are Distinguished by Elevated Expression of A1

1998 • 72 citations

Jak3 Selectively Regulates Bax and Bcl-2 Expression To Promote T-Cell Development

2001 • 64 citations

Constitutive Bcl-2 Expression during Immunoglobulin Heavy Chain–Promoted B Cell Differentiation Expands Novel Precursor B Cells

1997 • 57 citations

Continued differentiation during B lymphopoiesis requires signals in addition to cell survival

1997 • 38 citations

Signals and susceptibility to programmed death in B cells

1996 • 35 citations

High frequency of normal DJH joints in B cell progenitors in severe combined immunodeficiency mice.

1993 • 32 citations