Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

A general method for isolation of high molecular weight DNA from eukaryotes

1976 • 2,827 citations

A severe combined immunodeficiency mutation in the mouse

1983 • 2,193 citations

A New Mouse Myeloma Cell Line that Has Lost Immunoglobulin Expression but Permits the Construction of Antibody-Secreting Hybrid Cell Lines

1979 • 1,885 citations

The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition

1986 • 772 citations

Ordered rearrangement of immunoglobulin heavy chain variable region segments.

1984 • 736 citations

The identification in adult bone marrow of pluripotent and restricted stem cells of the myeloid and lymphoid systems

1977 • 563 citations

Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells

1984 • 540 citations

Developmental regulation of T-cell receptor gene expression

1985 • 522 citations

Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: Rearrangement of heavy but not light chain genes

1981 • 497 citations

Introduced T cell receptor variable region gene segments recombine in pre-B cells: Evidence that B and T cells use a common recombinase

1986 • 452 citations

CYTOLOGICAL EVIDENCE FOR A RELATIONSHIP BETWEEN NORMAL HEMATOPOIETIC COLONY-FORMING CELLS AND CELLS OF THE LYMPHOID SYSTEM

1968 • 441 citations

Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments.

1982 • 411 citations

Mouse T cell antigen receptor: Structure and organization of constant and joining gene segments encoding the β polypeptide

1984 • 407 citations

Chronic Myelocytic Leukemia

1978 • 332 citations

Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression

1981 • 319 citations

Severe combined immunodeficiency (SCID) in the mouse. Pathology, reconstitution, neoplasms.

1985 • 307 citations

Differentiation of lymphocytes in mouse bone marrow

1974 • 305 citations

A quantitative assay for transformation of bone marrow cells by Abelson murine leukemia virus.

1976 • 299 citations

Expression of T-cell antigen receptor genes during fetal development in the thymus

1985 • 293 citations

5′ Flanking region of immunoglobulin heavy chain constant region genes displays length heterogeneity in germlines of inbred mouse strains

1980 • 238 citations

Functional status of cells from lymphoid and myeloid tissues in mice with severe combined immunodeficiency disease.

1984 • 229 citations

The use of heparin as a simple cost-effective means of controlling background In nudeic acid hybridization procedures

1984 • 228 citations

Evidence that murine pre-B cells synthesise μ heavy chains but no light chains

1979 • 208 citations

The differentiation of T lymphocytes

1974 • 185 citations

Limited diversity of the rearranged T-cell γ gene

1985 • 185 citations

Rearrangement and transcription of the β-chain genes of the T-cell antigen receptor in different types of murine lymphocytes

1985 • 172 citations

A mutant immunoglobulin light chain is formed by aberrant DNA- and RNA-splicing events

1980 • 158 citations

T cell-specific gamma genes in C57BL/10 mice. Sequence and expression of new constant and variable region genes.

1986 • 154 citations

Differentiation of lymphocytes in mouse bone marrow

1974 • 141 citations

Monoclonal derivation of mouse myeloid and lymphoid lineages from totipotent hematopoietic stem cells experimentally engrafted in fetal hosts.

1984 • 117 citations

Nude Mice in Immunology

2015 • 114 citations

The effect of helper virus on Abelson virus-induced transformation of lymphoid cells.

1978 • 102 citations

Deletions of kappa chain constant region genes in mouse lambda chain-producing B cells involve intrachromosomal DNA recombinations similar to V-J joining.

1985 • 99 citations

AUTORADIOGRAPHIC ANALYSIS OF LYMPHOPOIESIS AND LYMPHOCYTE MIGRATION IN MICE BEARING MULTIPLE THYMUS GRAFTS

1966 • 95 citations

Chance, necessity and antibody gene dynamics

1983 • 87 citations

A novel type of aberrant recombination in immunoglobulin genes and its implications for V–J joining mechanism

1983 • 86 citations

Evidence of extensive lymphocyte death in sheep Peyer's patches. I. A comparison of lymphocyte production and export.

1986 • 84 citations

Transformation of Immature Lymphoid Cells by Abelson Murine Leukemia Virus

1979 • 77 citations

Hereditary Severe Combined Immunodeficiency and Adenosine Deaminase Deficiency

1976 • 73 citations

Immunoglobulin gene rearrangement during pre-B cell differentiation.

1983 • 64 citations

Nonproductive kappa immunoglobulin genes: recombinational abnormalities and other lesions affecting transcription, RNA processing, turnover, and translation.

1985 • 63 citations

Very rapid decay of mature B lymphocytes in the spleen.

1981 • 62 citations

Evidence of extensive lymphocyte death in sheep Peyer's patches. II. The number and fate of newly-formed lymphocytes that emigrate from Peyer's patches.

1986 • 39 citations