Characterization of the B Lymphocyte Populations in Lyn-Deficient Mice and the Role of Lyn in Signal Initiation and Down-Regulation

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

Clonal selection and learning in the antibody system

1996 • 1,710 citations

Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FeγRIIB

1996 • 770 citations

Defective B cell development and function in Btk-deficient mice

1995 • 729 citations

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1995 • 726 citations

Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

1995 • 710 citations

Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways.

1994 • 664 citations

Impairment of T-cell-dependent B-cell responses and B-l cell development in CD19-deficient mice

1995 • 663 citations

Syk tyrosine kinase required for mouse viability and B-cell development

1995 • 632 citations

A Role in B Cell Activation for CD22 and the Protein Tyrosine Phosphatase SHP

1995 • 551 citations

Abnormal B lymphocyte delevopment, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule

1995 • 546 citations

Recruitment and Activation of PTP1C in Negative Regulation of Antigen Receptor Signaling by FcγRIIB1

1995 • 535 citations

Hyperresponsive B Cells in CD22-Deficient Mice

1996 • 530 citations

Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death

1993 • 514 citations

Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice

1995 • 475 citations

Association of B Cell Antigen Receptor with Protein Tyrosine Kinase Lyn

1991 • 471 citations

EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor

1994 • 455 citations

Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires.

1996 • 451 citations

Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases.

1991 • 433 citations

Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells.

1993 • 413 citations

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav

1995 • 411 citations

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

1995 • 401 citations

Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection

1995 • 394 citations

Transitional B cells are the target of negative selection in the B cell compartment.

1995 • 352 citations

Self-Tolerance Checkpoints in B Lymphocyte Development

1995 • 329 citations

Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/56lyn.

1993 • 307 citations

Frequency of B lymphocytes responsive to anti-immunoglobulin.

1982 • 302 citations

Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling.

1994 • 299 citations

Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor.

1992 • 298 citations

Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen.

1994 • 293 citations

Production of Immunoglobulin Isotypes by Ly-1 ⁺ B Cells in Viable Motheaten and Normal Mice

1986 • 290 citations

Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate

1995 • 274 citations

Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling.

1995 • 260 citations

Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement.

1994 • 250 citations

Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45

1996 • 244 citations

The Src family of tyrosine protein kinases in hemopoietic signal transduction

1992 • 221 citations

Bruton tyrosine kinase is tyrosine phosphorylated and activated in pre-B lymphocytes and receptor-ligated B cells.

1994 • 196 citations

Motheaten, an immunodeficient mutant of the mouse. II. Depressed immune competence and elevated serum immunoglobulins.

1976 • 177 citations

B cell antigen receptor cross-linking induces phosphorylation of the p21ras oncoprotein activators SHC and mSOS1 as well as assembly of complexes containing SHC, GRB-2, mSOS1, and a 145-kDa tyrosine-phosphorylated protein.

1994 • 169 citations

Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice.

1996 • 152 citations

Catalytic Specificity of Phosphotyrosine Kinases Blk, Lyn, c-Src and Syk as Assessed by Phage Display

1996 • 139 citations

Distinctive Developmental Origins and Specificities of Murine CD5⁺ B Cells

1994 • 129 citations

B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn

1993 • 112 citations

Transmembrane signaling by antigen receptors of B and T lymphocytes

1995 • 109 citations

Amplification of human B cell activation by a monoclonal antibody to the B cell-specific antigen CD22, Bp 130/140.

1987 • 98 citations

Motheaten, an Immunodeficient Mutant of the Mouse

1976 • 94 citations

Tyrosine Phosphorylation of Shc Is Mediated through Lyn and Syk in B Cell Receptor Signaling

1995 • 93 citations

Role of tyrosine kinases in lymphocyte activation

1994 • 91 citations

Activation-induced Association of a 145-kDa Tyrosine-phosphorylated Protein with Shc and Syk in B Lymphocytes and Macrophages

1996 • 88 citations

Interactions of Lyn with the antigen receptor during B cell activation.

1994 • 66 citations

Phenotypic and Functional Effects of the Motheaten Gene on Murine B and T Lymphocytes

1979 • 63 citations

B cell antigen receptors

1994 • 58 citations

Reconstitution of B Cell Antigen Receptor-induced Signaling Events in a Nonlymphoid Cell Line by Expressing the Syk Protein-tyrosine Kinase

1996 • 57 citations

Selective activation of p42 mitogen-activated protein (MAP) kinase in murine B lymphoma cell lines by membrane immunoglobulin cross-linking. Evidence for protein kinase C-independent and -dependent mechanisms of activation

1992 • 56 citations

In Vivo and In Vitro Specificity of Protein Tyrosine Kinases for Immunoglobulin G Receptor (FcγRII) Phosphorylation

1996 • 56 citations

Examination of B lymphoid cell lines for membrane immunoglobulin-stimulated tyrosine phosphorylation and src-family tyrosine kinase mRNA expression

1992 • 43 citations

Signaling pathways activated by protein tyrosine phosphorylation in lymphocytes

1994 • 31 citations

The membrane immunoglobulin receptor utilizes a Shc/Grb2/hSOS complex for activation of the mitogen-activated protein kinase cascade in a B-cell line

1995 • 31 citations

Expression in Escherichia coli and characterization of a recombinant 7Fe ferredoxin of Rhodobacter capsulatus

1992 • 31 citations

src-family tyrosine kinase p55fgr is expressed in murine splenic B cells and is activated in response to antigen receptor cross-linking.

1995 • 29 citations

Tyrosine Phosphatases and the Antibody Response

1995 • 21 citations

Identification of a duplication of the mouse Lyn gene

1995 • 19 citations