Myeloid-Derived Suppressor Cells

Arginine metabolism: nitric oxide and beyond

1998 • 2,697 citations

Increased Production of Immature Myeloid Cells in Cancer Patients: A Mechanism of Immunosuppression in Cancer

2001 • 1,309 citations

Arginase I Production in the Tumor Microenvironment by Mature Myeloid Cells Inhibits T-Cell Receptor Expression and Antigen-Specific T-Cell Responses

2004 • 1,136 citations

Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis

2004 • 1,111 citations

Mechanisms and functional significance of tumour-induced dendritic-cell defects

2004 • 995 citations

Antigen-Specific Inhibition of CD8+ T Cell Response by Immature Myeloid Cells in Cancer Is Mediated by Reactive Oxygen Species

2004 • 825 citations

Arginase-Producing Myeloid Suppressor Cells in Renal Cell Carcinoma Patients: A Mechanism of Tumor Evasion

2005 • 811 citations

Transforming Growth Factor-β Production and Myeloid Cells Are an Effector Mechanism through Which CD1d-restricted T Cells Block Cytotoxic T Lymphocyte–mediated Tumor Immunosurveillance

2003 • 539 citations

Mechanism of Immune Dysfunction in Cancer Mediated by Immature Gr-1+ Myeloid Cells

2001 • 536 citations

All-trans-Retinoic Acid Improves Differentiation of Myeloid Cells and Immune Response in Cancer Patients

2006 • 529 citations

Identification of a CD11b+/Gr-1+/CD31+ myeloid progenitor capable of activating or suppressing CD8+T cells

2000 • 516 citations

Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells.

1991 • 512 citations

IL-4-Induced Arginase 1 Suppresses Alloreactive T Cells in Tumor-Bearing Mice

2003 • 499 citations

Reduction of Myeloid-Derived Suppressor Cells and Induction of M1 Macrophages Facilitate the Rejection of Established Metastatic Disease

2005 • 462 citations

Regulation of T Cell Receptor CD3ζ Chain Expression byl-Arginine

2002 • 460 citations

<scp>l</scp>-Arginine Consumption by Macrophages Modulates the Expression of CD3ζ Chain in T Lymphocytes

2003 • 458 citations

STAT1 Signaling Regulates Tumor-Associated Macrophage-Mediated T Cell Deletion

2005 • 431 citations

Unopposed Production of Granulocyte-Macrophage Colony-Stimulating Factor by Tumors Inhibits CD8+ T Cell Responses by Dysregulating Antigen-Presenting Cell Maturation

1999 • 406 citations

Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers

2005 • 377 citations

Gr-1+ Myeloid Cells Derived from Tumor-Bearing Mice Inhibit Primary T Cell Activation Induced Through CD3/CD28 Costimulation

2000 • 361 citations

Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 ζ chain of T-cell receptor complex and antigen-specific T-cell responses

1996 • 341 citations

Apoptotic Death of CD8+ T Lymphocytes After Immunization: Induction of a Suppressive Population of Mac-1+/Gr-1+ Cells

1998 • 321 citations

Nitric oxide biosynthesis, nitric oxide synthase inhibitors and arginase competition for L-arginine utilization

1999 • 311 citations

Tumor-Associated CD8+ T Cell Tolerance Induced by Bone Marrow-Derived Immature Myeloid Cells

2005 • 302 citations

Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity

2003 • 300 citations

Inhibition of myeloid cell differentiation in cancer: the role of reactive oxygen species

2003 • 289 citations

Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination

2005 • 282 citations

Tumor-Induced Immune Dysfunctions Caused by Myeloid Suppressor Cells

2001 • 245 citations

Synergy between T-cell immunity and inhibition of paracrine stimulation causes tumor rejection.

1995 • 169 citations

Tumor-Infiltrating Macrophages Induce Apoptosis in Activated CD8+ T Cells by a Mechanism Requiring Cell Contact and Mediated by Both the Cell-Associated Form of TNF and Nitric Oxide

2001 • 153 citations

Where have all the T cells gone? Mechanisms of immune evasion by tumors

1999 • 153 citations

Suppression of T cell proliferation by tumor-induced granulocyte-macrophage progenitor cells producing transforming growth factor-beta and nitric oxide.

1996 • 147 citations

Resection of Solid Tumors Reverses T Cell Defects and Restores Protective Immunity

2000 • 146 citations

Phase 1B study to improve immune responses in head and neck cancer patients using escalating doses of 25-hydroxyvitamin D 3

2004 • 144 citations

CD80+Gr-1+ Myeloid Cells Inhibit Development of Antifungal Th1 Immunity in Mice with Candidiasis

2002 • 138 citations

Role of Immature Myeloid Gr-1+ Cells in the Development of Antitumor Immunity

2004 • 138 citations

Vitamin A deficiency in mice causes a systemic expansion of myeloid cells

2000 • 137 citations

Nitric Oxide-Independent CTL Suppression during Tumor Progression: Association with Arginase-Producing (M2) Myeloid Cells

2003 • 108 citations

Myeloid progenitor cells mediate immune suppression in patients with head and neck cancers

1999 • 97 citations

Cyclophosphamide Induces the Development of Early Myeloid Cells Suppressing Tumor Cell Growth by a Nitric Oxide-Dependent Mechanism

2001 • 94 citations

Superantigen-Induced CD4 T Cell Tolerance Mediated by Myeloid Cells and IFN-γ

2000 • 93 citations

Development of splenic natural suppressor (NS) cells in ehrlich tumor‐bearing mice

1989 • 84 citations

Physiological Concentrations of Retinoic Acid Favor Myeloid Dendritic Cell Development over Granulocyte Development in Cultures of Bone Marrow Cells from Mice

2004 • 80 citations

Tumor Escape from Immune Response: Mechanisms and Targets of Activity

2003 • 76 citations

Retinoic acid receptor antagonism in vivo expands the numbers of precursor cells during granulopoiesis

2002 • 59 citations

Vitamin D3 Treatment to Diminish the Levels of Immune Suppressive CD34+ Cells Increases the Effectiveness of Adoptive Immunotherapy

2000 • 52 citations

CD34+ Immune Suppressive Cells in the Peripheral Blood of Patients with Head and Neck Cancer

2000 • 38 citations

Tumor skewing of CD34⁺ progenitor cell differentiation into endothelial cells

2004 • 24 citations

c‐kit⁺ FcR⁺ myelocytes are increased in cancer and prevent the proliferation of fully cytolytic T cells in the presence of immune serum

2002 • 23 citations

Cell‐cycle regulation of T‐cell responses – novel approaches to the control of alloimmunity

2003 • 17 citations