STAT1 Signaling Regulates Tumor-Associated Macrophage-Mediated T Cell Deletion

NITRIC OXIDE AND MACROPHAGE FUNCTION

1997 • 4,106 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

Arginase I Production in the Tumor Microenvironment by Mature Myeloid Cells Inhibits T-Cell Receptor Expression and Antigen-Specific T-Cell Responses

2004 • 1,136 citations

Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

2003 • 1,132 citations

Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention.

2002 • 1,027 citations

Antigen-Specific Inhibition of CD8+ T Cell Response by Immature Myeloid Cells in Cancer Is Mediated by Reactive Oxygen Species

2004 • 825 citations

The role of nitric oxide in cancer

2002 • 749 citations

L-arginine metabolism in myeloid cells controls T-lymphocyte functions

2003 • 580 citations

Transforming Growth Factor-β Production and Myeloid Cells Are an Effector Mechanism through Which CD1d-restricted T Cells Block Cytotoxic T Lymphocyte–mediated Tumor Immunosurveillance

2003 • 539 citations

Determination of arginase activity in macrophages: a micromethod

1994 • 536 citations

Mechanism of Immune Dysfunction in Cancer Mediated by Immature Gr-1+ Myeloid Cells

2001 • 536 citations

IL-4-Induced Arginase 1 Suppresses Alloreactive T Cells in Tumor-Bearing Mice

2003 • 499 citations

Regulation of T Cell Receptor CD3ζ Chain Expression byl-Arginine

2002 • 460 citations

Hyperactivation of STAT3 Is Involved in Abnormal Differentiation of Dendritic Cells in Cancer

2004 • 458 citations

<scp>l</scp>-Arginine Consumption by Macrophages Modulates the Expression of CD3ζ Chain in T Lymphocytes

2003 • 458 citations

Hydrogen peroxide secreted by tumor‐derived macrophages down‐modulates signal‐transducing zeta molecules and inhibits tumor‐specific T cell‐and natural killer cell‐mediated cytotoxicity

1996 • 364 citations

Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 ζ chain of T-cell receptor complex and antigen-specific T-cell responses

1996 • 341 citations

Apoptotic Death of CD8+ T Lymphocytes After Immunization: Induction of a Suppressive Population of Mac-1+/Gr-1+ Cells

1998 • 321 citations

Immature myeloid cells and cancer-associated immune suppression

2002 • 304 citations

Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity

2003 • 300 citations

Inhibition of myeloid cell differentiation in cancer: the role of reactive oxygen species

2003 • 289 citations

Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity.

2001 • 289 citations

Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor κB

2002 • 253 citations

Tumor-Induced Immune Dysfunctions Caused by Myeloid Suppressor Cells

2001 • 245 citations

Tumor-induced regulation of suppressor macrophage nitric oxide and TNF-alpha production. Role of tumor-derived IL-10, TGF-beta, and prostaglandin E2.

1994 • 244 citations

Tumor-Infiltrating Macrophages Induce Apoptosis in Activated CD8+ T Cells by a Mechanism Requiring Cell Contact and Mediated by Both the Cell-Associated Form of TNF and Nitric Oxide

2001 • 153 citations

Cutting Edge: STAT6-Deficient Mice Have Enhanced Tumor Immunity to Primary and Metastatic Mammary Carcinoma

2000 • 147 citations

Suppression of T cell proliferation by tumor-induced granulocyte-macrophage progenitor cells producing transforming growth factor-beta and nitric oxide.

1996 • 147 citations

Role of Immature Myeloid Gr-1+ Cells in the Development of Antitumor Immunity

2004 • 138 citations

Expansion of immunoregulatory macrophages by granulocyte-macrophage colony-stimulating factor derived from a murine mammary tumor.

1990 • 130 citations

Signalling events involved in interferon‐γ‐inducible macrophage nitric oxide generation

2003 • 127 citations

Suppression of the Humoral Immune Response by Plasmacytomas: Mediation by Adherent Mononuclear Cells

1977 • 101 citations

Negative regulation of macrophage activation in response to IFN-gamma and lipopolysaccharide by the STK/RON receptor tyrosine kinase.

1999 • 89 citations

Tumour escape: antitumour effectors too much of a good thing?

2004 • 87 citations

Mice Bearing Late-Stage Tumors Have Normal Functional Systemic T Cell Responses In Vitro and In Vivo

2000 • 79 citations

Cancer-induced Defective Cytotoxic T Lymphocyte Effector Function: Another Mechanism How Antigenic Tumors Escape Immune-mediated Killing

2000 • 78 citations

Negative Regulation of Macrophage Activation in Response to IFN-γ and Lipopolysaccharide by the STK/RON Receptor Tyrosine Kinase

1999 • 78 citations

Splenic Macrophages From Tumor-Bearing Mice Co-Expressing MAC-1 and MAC-2 Antigens Exert Immunoregulatory Functions Via Two Distinct Mechanisms

1991 • 69 citations

The role of tumor-derived cytokines on the immune system of mice bearing a mammary adenocarcinoma. I. Induction of regulatory macrophages in normal mice by the in vivo administration of rGM-CSF.

1991 • 65 citations

Aberrant antigen presentation by macrophages from tumor-bearing mice is involved in the down-regulation of their T cell responses.

1995 • 63 citations

CD8+ Tumor-Infiltrating Lymphocytes Are Primed for Fas-Mediated Activation-Induced Cell Death But Are Not Apoptotic In Situ

2001 • 58 citations

Signal transducer and activator of transcription 6 (Stat6) and CD1: inhibitors of immunosurveillance against primary tumors and metastatic disease

2004 • 32 citations

Tumor-Induced Macrophage Tumor Necrosis Factor-α Production Suppresses Autoreactive T Cell Proliferation

1993 • 19 citations

The T cell death knell: immune-mediated tumor death in renal cell carcinoma.

2001 • 18 citations

Specific T Cell-Dependent, Antigen-Antibody Mediated Suppression of Macrophages: Abrogation by Nonspecifically Stimulated T Cells

1977 • 10 citations

Immune Defects in Cancer

2004 • 2 citations