Constitutive Nuclear Translocation of NF-κB in B Cells in the Absence of IκB Degradation

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

NF-κB: Ten Years After

1996 • 3,008 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

An inducible transcription factor activates expression of human immunodeficiency virus in T cells

1987 • 2,149 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B.

1989 • 1,660 citations

NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway

1993 • 1,141 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

Signal transduction through NF-κB

1998 • 1,103 citations

In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death

1997 • 1,091 citations

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.

1993 • 1,047 citations

IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System

1993 • 967 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

Tyrosine Phosphorylation of IκB-α Activates NF-κB without Proteolytic Degradation of IκB-α

1996 • 665 citations

Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.

1993 • 639 citations

Regulation of the NF-ηB/rel transcription factor and IηB inhibitor system

1993 • 541 citations

A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB.

1989 • 517 citations

NF-κB Activation: The IκB Kinase Revealed?

1997 • 492 citations

NF-κB and Rel Proteins in Innate Immunity

1995 • 435 citations

The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV

1988 • 427 citations

I kappa B epsilon, a novel member of the Ikappa B family, controls RelA and cRel NF-kappa B activity

1997 • 394 citations

Rel/NF-κB and IκB proteins: an overview

1997 • 372 citations

The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms.

1993 • 361 citations

In vivo control of NF-kappa B activation by I kappa B alpha.

1993 • 326 citations

The v-rel oncogene encodes a κB enhancer binding protein that inhibits NF-κB function

1990 • 325 citations

Two better cell lines for making hybridomas expressing specific T cell receptors.

1989 • 300 citations

REL/NF-κB/IκB Story

1995 • 278 citations

Sequential Induction of NF-κB/Rel Family Proteins during B-Cell Terminal Differentiation

1994 • 275 citations

NF-kappa B: a family of inducible and differentially expressed enhancer-binding proteins in human T cells.

1990 • 260 citations

Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas.

1982 • 252 citations

B Lymphocytes Differentially Use the Rel and Nuclear Factor κB1 (NF-κB1) Transcription Factors to Regulate Cell Cycle Progression and Apoptosis in Quiescent and Mitogen-activated Cells

1998 • 250 citations

Rel/NF-κB transcription factors and the control of apoptosis

1997 • 242 citations

Regulation of Immune Responses by NF-κB/Rel Transcription Factors

1998 • 193 citations

Induction of the transcription factors NF-кB, AP-1 and NF-AT during B cell stimulation through the CD40 receptor

1995 • 192 citations

Role of Rel-related factors in control of c-myc gene transcription in receptor-mediated apoptosis of the murine B cell WEHI 231 line.

1995 • 162 citations

The CH Series of Murine B Cell Lymphomas: Neoplastic Analogues of Ly‐1⁺ Normal B Cells

1986 • 161 citations

CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction.

1997 • 136 citations

Qualitative changes in the subunit composition of kappa B-binding complexes during murine B-cell differentiation.

1994 • 125 citations

Novel IκBα Proteolytic Pathway in WEHI231 Immature B Cells

1998 • 120 citations

Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activity.

1994 • 114 citations

Maintenance of nuclear factor-kappa B/Rel and c-myc expression during CD40 ligand rescue of WEHI 231 early B cells from receptor-mediated apoptosis through modulation of I kappa B proteins.

1996 • 97 citations

Cloning and functional characterization of mouse IκBɛ

1997 • 89 citations

Activation of NF-κB/Rel by CD40 Engagement Induces the Mouse Germ Line Immunoglobulin Cγ1 Promoter

1996 • 85 citations

Regulation of IκBβ in WEHI 231 Mature B Cells

1997 • 74 citations

Corepression of RelA and c-Rel Inhibits Immunoglobulin κ Gene Transcription and Rearrangement in Precursor B Lymphocytes

1996 • 70 citations

Complex regulation of class II gene expression: analysis with class II mutant cell lines.

1985 • 67 citations

Molecular events in B lymphocyte differentiation. Inducible expression of the endogenous mouse mammary tumor proviral gene, Mtv-9.

1990 • 58 citations

CD40, but not lipopolysaccharide and anti-IgM stimulation of primary B lymphocytes, leads to a persistent nuclear accumulation of RelB.

1996 • 47 citations

Ig isotype switching in B lymphocytes. Isolation and characterization of clonal variants of the murine Ly-1+ B cell lymphoma, CH12, expressing isotypes other than IgM.

1988 • 45 citations

Enhanced ΙκΒα Degradation Is Responsible for Constitutive NF-κΒ Activity in Mature Murine B-Cell Lines

1994 • 41 citations

Receptor-specific induction of NF-kappaB components in primary B cells

1998 • 38 citations

Regulated expression of mouse mammary tumor proviral genes in cells of the B lineage.

1991 • 35 citations

Expression of Protein Tyrosine Kinases in the Ig Complex of anti‐μ‐Sensitive and anti‐μ‐Resistant B‐Cell Lymphomas: Role of the p55^blk Kinase in Signaling Growth Arrest and Apoptosis

1993 • 34 citations

Induction of Nuclear Factor-κB During Primary B Cell Differentiation

1998 • 31 citations

Characterization of a presecretory phase in B-cell differentiation.

1989 • 30 citations

Quantitation of cell surface molecules on a differentiating, Ly-1+ B cell lymphoma.

1987 • 30 citations

Dominant Signals Leading to Inhibitor κB Protein Degradation Mediate CD40 Ligand Rescue of WEHI 231 Immature B Cells from Receptor-Mediated Apoptosis

1998 • 25 citations

Secretion of soluble pre-B cell receptors by pre-B cells.

1997 • 16 citations