Muc-1 Core Protein Is Expressed on Multiple Myeloma Cells and Is Induced by Dexamethasone

Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin.

1990 • 994 citations

Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells

1991 • 869 citations

Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells

1997 • 596 citations

Kaposi's Sarcoma-Associated Herpesvirus Infection of Bone Marrow Dendritic Cells from Multiple Myeloma Patients

1997 • 491 citations

Specific, major histocompatibility complex-unrestricted recognition of tumor-associated mucins by human cytotoxic T cells.

1989 • 453 citations

Mechanisms Underlying Aberrant Glycosylation of MUC1 Mucin in Breast Cancer Cells

1995 • 347 citations

Coexpression of epithelial membrane antigen (EMA), Ki-1, and interleukin-2 receptor by anaplastic large cell lymphomas. Diagnostic value in so-called malignant histiocytosis.

1988 • 343 citations

Epithelial membrane antigen—A diagnostic discriminant in surgical pathology: Immunohistochemical profile in epithelial, mesenchymal, and hematopoietic neoplasms using paraffin sections and monoclonal antibodies

1985 • 317 citations

Humoral immunity against a tandem repeat epitope of human mucin MUC-1 in sera from breast, pancreatic, and colon cancer patients.

1994 • 307 citations

Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2

1998 • 297 citations

The epithelial mucin, MUC1, of milk, mammary gland and other tissues

1995 • 285 citations

HUMAN LYMPHOID CELLS EXPRESS EPITHELIAL MEMBRANE ANTIGEN

1984 • 274 citations

Antibody and T cell responses of patients with adenocarcinoma immunized with mannan-MUC1 fusion protein.

1997 • 269 citations

Expression and steroid hormonal control of Muc-1 in the mouse uterus.

1995 • 267 citations

Studies on the clonal origin of multiple myeloma. Use of individually specific (idiotype) antibodies to trace the oncogenic event to its earliest point of expression in B-cell differentiation.

1979 • 255 citations

The bone marrow of multiple myeloma patients contains B cell populations at different stages of differentiation that are clonally related to the malignant plasma cell.

1993 • 248 citations

SUCCESSFUL TREATMENT OF DIPHYLLOBOTHRIUM LATUM AND TAENIA SAGINATA INFECTION BY INTRADUODENAL 'GASTROGRAFIN' INJECTION

1986 • 245 citations

Summary Report on the ISOBM TD-4 Workshop: Analysis of 56 Monoclonal Antibodies against the MUC1 Mucin

1998 • 224 citations

The breast mucin MUCI as a novel adhesion ligand for endothelial intercellular adhesion molecule 1 in breast cancer.

1996 • 221 citations

Episialin (MUC1) inhibits cytotoxic lymphocyte-target cell interaction.

1993 • 221 citations

Tissue and tumor distribution of human polymorphic epithelial mucin

1988 • 219 citations

Cytotoxic T cells from ovarian malignant tumors can recognize polymorphic epithelial mucin core peptides.

1993 • 213 citations

Expression of MUC1 on myeloma cells and induction of HLA-unrestricted CTL against MUC1 from a multiple myeloma patient.

1994 • 180 citations

Adjuvant therapy of ovarian cancer with radioactive monoclonal antibody

1993 • 171 citations

In multiple myeloma, clonotypic B lymphocytes are detectable among CD19+ peripheral blood cells expressing CD38, CD56, and monotypic Ig light chain [published erratum appears in Blood 1995 Jun 1;85(11):3365]

1995 • 162 citations

Regulation of human B-cell precursor adhesion to bone marrow stromal cells by cytokines that exert opposing effects on the expression of vascular cell adhesion molecule-1 (VCAM-1)

1993 • 155 citations

Evidence that the clonogenic cell in multiple myeloma originates from a pre‐switched but somatically mutated B cell

1994 • 152 citations

Structure and expression of the human polymorphic epithelial mucin gene: an expressed VNTR unit

1990 • 152 citations

The role of interleukin‐1 and tumour necrosis factor‐α in human multiple myeloma

1990 • 151 citations

A High Frequency of Circulating B Cells Share Clonotypic Ig Heavy-Chain VDJ Rearrangements With Autologous Bone Marrow Plasma Cells in Multiple Myeloma, as Measured by Single-Cell and In Situ Reverse Transcriptase-Polymerase Chain Reaction

1998 • 150 citations

Selective expression of CD45 isoforms defines CALLA+ monoclonal B- lineage cells in peripheral blood from myeloma patients as late stage B cells

1991 • 129 citations

In multiple myeloma, clonotypic B lymphocytes are detectable among CD19+ peripheral blood cells expressing CD38, CD56, and monotypic Ig light chain [published erratum appears in Blood 1995 Jun 1;85(11):3365]

1995 • 126 citations

Rapid Engraftment Without Significant Graft-Versus-Host Disease After Allogeneic Transplantation of CD34+ Selected Cells From Peripheral Blood

1997 • 124 citations

CD34+ Cells in the Blood of Patients With Multiple Myeloma Express CD19 and IgH mRNA and Have Patient-Specific IgH VDJ Gene Rearrangements

1997 • 118 citations

Polymorphic epithelial mucin (MUC-1)-containing circulating immune complexes in carcinoma patients

1995 • 113 citations

Mucin (Muc-1) Expression is Differentially Regulated in Uterine Luminal and Glandular Epithelia of the Baboon (Papio Anubis)1

1996 • 112 citations

Definition of the thymic generative lineage by selective expression of high molecular weight isoforms of CD45 (T200)

1989 • 108 citations

Tumor selective reactivity of a monoclonal antibody prepared against a recombinant peptide derived from the DF3 human breast carcinoma-associated antigen.

1992 • 102 citations

Augmenting the immunogenicity of synthetic MUC1 peptide vaccines in mice.

1996 • 98 citations

Preliminary studies for an immunotherapeutic approach to the treatment of human myeloma using chimeric anti-CD38 antibody

1991 • 96 citations

Immunotherapy of Multiple Myeloma With a Monoclonal Antibody Directed Against a Plasma Cell-Specific Antigen, HM1.24

1997 • 86 citations

Intramuscular immunisation withMUC1 cDNA can protect C57 mice challenged with MUC1-expressing syngeneic mouse tumour cells

1996 • 85 citations

Role of interleukin-6 in the proliferation of human multiple myeloma cell lines OCI-My 1 to 7 established from patients with advanced stage of the disease

1991 • 85 citations

Interleukin-6 in multiple myeloma and related plasma cell dyscrasias

1998 • 84 citations

Anti-CD38-blocked ricin: an immunotoxin for the treatment of multiple myeloma [see comments]

1994 • 79 citations

Phenotypic analysis of human myeloma cell lines

1989 • 74 citations

Therapeutic Antitumor Response After Immunization with an Admixture of Recombinant Vaccinia Viruses Expressing a Modified MUC1 Gene and the Murine T-Cell Costimulatory Molecule B7

1997 • 69 citations

Regulation of adhesion molecule expression in Kaposi's sarcoma cells.

1994 • 66 citations

Anti-CD38-blocked ricin: an immunotoxin for the treatment of multiple myeloma [see comments]

1994 • 64 citations

Deficient Drug Transporter Function of Bone Marrow–Localized and Leukemic Plasma Cells in Multiple Myeloma

1997 • 62 citations

Anti-CD54 (ICAM-1) has antitumor activity in SCID mice with human myeloma cells.

1995 • 60 citations

The pharmacokinetics of single high doses of dexamethasone in cancer patients

1987 • 59 citations

Reactivity of monoclonal antibody DF3 with a high molecular weight antigen expressed in human ovarian carcinomas.

1986 • 53 citations

Characterization of bone marrow stromal cells from multiple myeloma

1994 • 40 citations

Epitope Mapping of Anti-MUC1 Mucin Protein Core Monoclonal Antibodies

1998 • 39 citations

An improved technique for obtaining e rosettes with human lymphocytes and its use for B cell purification

1976 • 38 citations

An interleukin 1 receptor antagonist blocks the IL-1-induced IL-6 paracrine production through a prostaglandin E2-related mechanism in multiple myeloma.

1995 • 37 citations

Immunohistochemical Characterization of a Panel of 56 Antibodies with Normal Human Small Intestine, Colon, and Breast Tissues

1998 • 35 citations

Isolation and characterization of an expressed hypervariable gene coding for a breast-cancer-associated antigen

1990 • 31 citations

Efficacy and toxicity of plasma-cell-reactive monoclonal antibodies B-B2 and B-B4 and their immunotoxins

1996 • 26 citations

Antioxidant-Sensitive Regulation of Inflammatory-Response Genes in Kaposi's Sarcoma Cells

1996 • 26 citations

Evaluation of CD38 as target for immunotherapy in multiple myeloma [letter; comment]

1995 • 24 citations

Specificity Clusters of MUC1-Reactive Mouse Monoclonal Antibodies

1998 • 22 citations

Effect of Desialylation on Binding, Affinity, and Specificity of 56 Monoclonal Antibodies against MUC1 Mucin

1998 • 21 citations

Acquisition of growth autonomy and tumorigenicity by an interleukin 6-dependent human myeloma cell line transfected with interleukin 6 cDNA.

1992 • 21 citations

B-cell lymphoma marking only with anti-epithelial. Membrane antigen

1989 • 14 citations