Photo-oxidative Stress Down-modulates the Activity of Nuclear Factor-κB via Involvement of Caspase-1, Leading to Apoptosis of Photoreceptor Cells

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Improved method for the determination of blood glutathione.

1963 • 6,733 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1991 • 2,362 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor

1988 • 1,200 citations

NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway

1993 • 1,141 citations

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.

1993 • 1,047 citations

IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System

1993 • 967 citations

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control

1997 • 875 citations

The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors.

1993 • 819 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

Coupling of a Signal Response Domain in IκBα to Multiple Pathways for NF-κB Activation

1995 • 706 citations

Regulation of the NF-ηB/rel transcription factor and IηB inhibitor system

1993 • 541 citations

Apoptosis: Activate NF-κB or die?

1997 • 524 citations

Role of Oxidants and Antioxidants in the Induction of AP-1, NF-κB, and Glutathione S-Transferase Gene Expression

1996 • 457 citations

NFkappaB prevents apoptosis and liver dysfunction during liver regeneration.

1998 • 454 citations

Purified human IκB can rapidly dissociate the complex of the NF-κB transcription factor with its cognate DNA

1990 • 445 citations

Constitutive NF-kB Activity in Neurons

1994 • 400 citations

Hyperglycemia Can Cause Membrane Lipid Peroxidation and Osmotic Fragility in Human Red Blood Cells

1989 • 377 citations

Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis.

1996 • 352 citations

Nuclear uptake control of NF-kappa B by MAD-3, an I kappa B protein present in the nucleus.

1993 • 330 citations

Constitutive Activation of NF-κB Causes Resistance to Apoptosis in Human Cutaneous T Cell Lymphoma HuT-78 Cells

1998 • 300 citations

Regulation of Ubiquitin-conjugating Enzymes by Glutathione Following Oxidative Stress

1997 • 283 citations

Redox signalling by transcription factors NF-κB and AP-1 in lymphocytes

1995 • 258 citations

Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-kappa B.

1995 • 250 citations

Activation of NF‐κB by ER stress requires both Ca²⁺ and reactive oxygen intermediates as messengers

1996 • 215 citations

Apoptosis leads to photoreceptor degeneration in inherited retinal dystrophy of RCS rats.

1994 • 214 citations

Bilateral retinal and brain tumors in transgenic mice expressing simian virus 40 large T antigen under control of the human interphotoreceptor retinoid-binding protein promoter.

1992 • 213 citations

Free Radicals in Diagnostic Medicine

1994 • 204 citations

Rapid Plasmenylethanolamine-Selective Fusion of Membrane Bilayers Catalyzed by an Isoform of Glyceraldehyde-3-Phosphate Dehydrogenase: Discrimination between Glycolytic and Fusogenic Roles of Individual Isoforms

1995 • 203 citations

Correction of Radiation Sensitivity in Ataxia Telangiectasia Cells by a Truncated IκB-α

1995 • 173 citations

Light-induced acceleration of photoreceptor degeneration in transgenic mice expressing mutant rhodopsin.

1996 • 171 citations

Phosphorylation of IκB-α Inhibits Its Cleavage by Caspase CPP32 in Vitro

1997 • 147 citations

Light-induced free radical oxidation of membrane lipids in photoreceptors of frog retina

1973 • 146 citations

CD95 (Fas)-induced caspase-mediated proteolysis of NF-kappaB.

1998 • 123 citations

SRF and TEF-1 control of chicken skeletal alpha-actin gene during slow-muscle hypertrophy

1996 • 120 citations

Retinitis pigmentosa: unfolding its mystery.

1996 • 113 citations

Nuclear Factor-κB Is Activated by Hyperoxia but Does Not Protect from Cell Death

1997 • 106 citations

Involvement of intracellular Ca²⁺ in oxidant‐induced NF‐κB activation

1996 • 105 citations

Optimal NFκB Mediated Transcriptional Responses in Jurkat T Cells Exposed to Oxidative Stress Are Dependent on Intracellular Glutathione and Costimulatory Signals

1996 • 102 citations

Degenerative Diseases of the Retina

1995 • 92 citations

Oxidative Stress, Cell Activation and Viral Infection

1994 • 91 citations

Region and age-dependent variation in susceptibility of the human retina to lipid peroxidation.

1992 • 88 citations

Superoxide dismutase of bovine and frog rod outer segments

1975 • 84 citations

Death at an early age. Apoptosis in inherited retinal degenerations.

1995 • 79 citations

Separate mechanisms for retinal damage by ultraviolet-A and mid-visible light.

1990 • 70 citations

Expression and induction of nuclear factor-kappa B-related proteins in thymocytes.

1995 • 62 citations

Antioxidants differentially affect nuclear factor κB‐mediated nitric oxide synthase expression in vascular smooth muscle cells

1996 • 42 citations

Opsin synthesis and mRNA levels in dystrophic retinas devoid of outer segments in retinal degeneration slow (rds) mice

1990 • 30 citations

Unscheduled DNA Replication Precedes Apoptosis of Photoreceptors Expressing SV40 T Antigen

1997 • 25 citations

Retinal Degenerations

1985 • 24 citations

Immunocytochemical Colocalization of Clusterin in Apoptotic Photoreceptor Cells in Retinal Degeneration SlowrdsMutant Mouse Retinas

1996 • 24 citations

Reduced and oxidized pyridine nucleotides in the retinae from alloxan-diabetic rats

1962 • 13 citations