Nuclear Factor κB Nuclear Translocation Upregulates c-Myc and p53 Expression during NMDA Receptor-Mediated Apoptosis in Rat Striatum

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

NF-κB: Ten Years After

1996 • 3,008 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

Excitotoxic cell death

1992 • 2,307 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1995 • 1,892 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

1997 • 1,016 citations

NF-kB: a crucial transcription factor for glial and neuronal cell function

1997 • 1,005 citations

Inhibition of Nuclear Translocation of Transcription Factor NF-κB by a Synthetic Peptide Containing a Cell Membrane-permeable Motif and Nuclear Localization Sequence

1995 • 923 citations

Neuroprotection by Aspirin and Sodium Salicylate Through Blockade of NF-κB Activation

1996 • 760 citations

Mediation of c-Myc-Induced Apoptosis by p53

1994 • 741 citations

Nuclear translocation of NF-κB is increased in dopaminergic neurons of patients with Parkinson disease

1997 • 676 citations

Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.

1995 • 632 citations

Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease

1997 • 611 citations

Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells.

1996 • 604 citations

Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models

1995 • 604 citations

Activation of NF-?B protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration

1997 • 572 citations

Apoptosis: Activate NF-κB or die?

1997 • 524 citations

P53, cell cycle control and apoptosis: Implications for cancer

1995 • 467 citations

Loss of the p53 tumor suppressor gene protects neurons from kainate- induced cell death

1996 • 378 citations

NF-kappa B activation of p53. A potential mechanism for suppressing cell growth in response to stress.

1994 • 361 citations

Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis.

1996 • 352 citations

Attenuation of p53 Expression Protects against Focal Ischemic Damage in Transgenic Mice

1994 • 317 citations

Stimulation of ionotropic glutamate receptors activates transcription factor NF-kappa B in primary neurons.

1995 • 312 citations

Constitutive NF-kappa B activity in neurons.

1994 • 304 citations

Synaptic activation of NF-kappa B by glutamate in cerebellar granule neurons in vitro.

1995 • 289 citations

Mechanisms of Neuronal Death in Alzheimer's Disease

1996 • 267 citations

Interaction of an NF-kappa B-like factor with a site upstream of the c-myc promoter.

1990 • 263 citations

p53 induction is associated with neuronal damage in the central nervous system.

1994 • 262 citations

Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-kappa B.

1995 • 250 citations

Evidence for p53-Mediated Modulation of Neuronal Viability

1996 • 247 citations

Distinct combinations of NF-kappa B subunits determine the specificity of transcriptional activation.

1992 • 245 citations

High levels of c-rel expression are associated with programmed cell death in the developing avian embryo and in bone marrow cells in vitro

1993 • 231 citations

Brain synapses contain inducible forms of the transcription factor NF-κB

1993 • 225 citations

Global Ischemia Activates Nuclear Factor-κB in Forebrain Neurons of Rats

1997 • 219 citations

Enhancement of immunoreactivity for NF-κB in the hippocampal formation and cerebral cortex of Alzheimer's disease

1996 • 208 citations

p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats.

1994 • 183 citations

Inhibition of nuclear factor kappa B (NF?B) activity induces nerve growth factor-resistant apoptosis in PC12 cells

1997 • 177 citations

p53 Expression Induces Apoptosis in Hippocampal Pyramidal Neuron Cultures

1997 • 169 citations

Nuclear Factor-κB Contributes to Excitotoxin-Induced Apoptosis in Rat Striatum

1998 • 167 citations

Janus faces of NF-κB: Neurodestruction versus neuroprotection

1997 • 163 citations

Role of Rel-related factors in control of c-myc gene transcription in receptor-mediated apoptosis of the murine B cell WEHI 231 line.

1995 • 162 citations

Adenovirus-mediated gene transfer of the tumor suppressor, p53, induces apoptosis in postmitotic neurons.

1996 • 125 citations

p53: A Cell Cycle Regulator Activated by DNA Damage

1995 • 121 citations

p53 Expression in brain after middle cerebral artery occlusion in the rat

1992 • 120 citations

Drug-Induced Neuroprotection From Global Ischemia Is Associated With Prevention of Persistent but Not Transient Activation of Nuclear Factor-κB in Rats

1998 • 113 citations

Excitotoxic lesion of rat brain with quinolinic acid induces expression of p53 messenger RNA and protein and p53-inducible genes Bax and Gadd-45 in brain areas showing DNA fragmentation

1996 • 111 citations

NF-kappa B-like factors mediate interleukin 1 induction of c-myc gene transcription in fibroblasts.

1992 • 109 citations

c-Myc induces apoptosis and cell cycle progression by separable, yet overlapping, pathways.

1996 • 101 citations

Stimulation of N-methyl-d-aspartate receptors induces apoptosis in rat brain

1996 • 89 citations

NF‐κB inhibitors stimulate apoptosis of rabbit mature osteoclasts and inhibit bone resorption by these cells

1997 • 76 citations

Apoptosis in neurodegenerative disorders

1997 • 72 citations

Normal p53 status and function despite the development of drug resistance in human breast cancer cells.

1995 • 72 citations

Kainate induces apoptosis in neurons

1996 • 67 citations

NF-κB Activation by Triphenyltin Triggers Apoptosis in HL-60 Cells

1996 • 52 citations

Up-regulation of c-myc gene expression following focal ischemia in the rat brain

1996 • 35 citations

Neuronal cell death: searching for the smoking gun

1994 • 22 citations

Wild type p53 and c-myc co-operation in generating apoptosis of a rat hepatocellular carcinoma cell line (FAA-HTC1).

1995 • 19 citations