Regulation of LPA-Promoted Myofibroblast Contraction: Role of Rho, Myosin Light Chain Kinase, and Myosin Light Chain Phosphatase

Physiology of the Gastrointestinal Tract

2006 • 4,704 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

Signal transduction and regulation in smooth muscle

1994 • 1,915 citations

FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING

1996 • 1,900 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing.

1990 • 1,176 citations

Fibroblasts, myofibroblasts, and wound contraction

1994 • 1,150 citations

Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

1997 • 1,085 citations

Calyculin A and okadaic acid: Inhibitors of protein phosphatase activity

1989 • 1,032 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

The bioactive phospholipid lysophosphatidic acid is released from activated platelets

1993 • 653 citations

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

1994 • 617 citations

α-Actinin: Immunofluorescent localization of a muscle structural protein in nonmuscle cells

1975 • 599 citations

Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger

1995 • 592 citations

Rho-mediated Contractility Exposes a Cryptic Site in Fibronectin and Induces Fibronectin Matrix Assembly

1998 • 589 citations

Rho-associated Kinase Directly Induces Smooth Muscle Contraction through Myosin Light Chain Phosphorylation

1997 • 576 citations

Asparagine residue in the rho Gene Product Is the Modification Site for Botulinum ADP-ribosyltransferase

1989 • 550 citations

Regulation of endothelial cell gap formation and barrier dysfunction: Role of myosin light chain phosphorylation

1995 • 550 citations

Characterization of a Novel Subtype of Human G Protein-coupled Receptor for Lysophosphatidic Acid

1998 • 535 citations

Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase.

1994 • 469 citations

Molecular Dissection of the Rho-associated Protein Kinase (p160ROCK)-regulated Neurite Remodeling in Neuroblastoma N1E-115 Cells

1998 • 465 citations

Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction.

1992 • 458 citations

Gα12 and Gα13 Stimulate Rho-dependent Stress Fiber Formation and Focal Adhesion Assembly

1995 • 443 citations

Physiology of the Gastrointestinal Tract

1988 • 438 citations

Receptor-coupled, Permeabilized Smooth Muscle

1989 • 429 citations

Phosphorylation of platelet myosin increases actin-activated myosin ATPase activity

1975 • 413 citations

Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.

1993 • 377 citations

Regulation of Smooth Muscle Contractile Elements by Second Messengers

1989 • 357 citations

CONTROL OF NONMUSCLE MYOSINS BY PHOSPHORYLATION

1992 • 338 citations

G protein-mediated inhibition of myosin light-chain phosphatase in vascular smooth muscle.

1991 • 319 citations

Myosin is involved in postmitotic cell spreading.

1995 • 306 citations

Role of guanine nucleotide-binding proteins--ras-family or trimeric proteins or both--in Ca2+ sensitization of smooth muscle.

1996 • 280 citations

Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor.

1996 • 280 citations

A single receptor encoded by vzg-1 / lp _A1 / edg- 2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid

1998 • 280 citations

Stress fiber sarcomeres of fibroblasts are contractile

1980 • 277 citations

Lysophosphatidic acid stimulates tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130. Signaling pathways and cross-talk with platelet-derived growth factor.

1994 • 264 citations

Characterization of the myosin-binding subunit of smooth muscle myosin phosphatase.

1994 • 261 citations

In vivo co-distribution of fibronectin and actin fibers in granulation tissue: immunofluorescence and electron microscope studies of the fibronexus at the myofibroblast surface.

1984 • 261 citations

Fibroblast contraction occurs on release of tension in attached collagen lattices: Dependency on an organized actin cytoskeleton and serum

1992 • 249 citations

Identification of cDNAs encoding two G protein‐coupled receptors for lysosphingolipids¹

1997 • 247 citations

Myosin II activation promotes neurite retraction during the action of Rho and Rho‐kinase

1998 • 243 citations

Biochemistry of the contractile process in smooth muscle

1987 • 231 citations

Stress relaxation of contracted collagen gels: Disruption of actin filament bundles, release of cell surface fibronectin, and down-regulation of DNA and protein synthesis

1991 • 217 citations

Myosin light chain phosphatase activities and the effects of phosphatase inhibitors in tonic and phasic smooth muscle.

1992 • 214 citations

α-Smooth muscle actin is expressed in a subpopulation of cultured and cloned fibroblasts and is modulated by γ-interferon

1992 • 209 citations

Purification and characterization of the mammalian myosin light chain phosphatase holoenzyme. The differential effects of the holoenzyme and its subunits on smooth muscle.

1994 • 205 citations

Isolation and Contraction of the Stress Fiber

1998 • 203 citations

Identification of a putative membrane receptor for the bioactive phospholipid, lysophosphatidic acid.

1992 • 199 citations

Regulation of cytoplasmic and smooth muscle myosin

1991 • 196 citations

Lysophosphatidic acids induce proliferation of cultured vascular smooth muscle cells from rat aorta

1994 • 195 citations

ADP-ribosylation of the rhoA gene product by botulinum C3 exoenzyme causes Swiss 3T3 cells to accumulate in the G1 phase of the cell cycle.

1993 • 186 citations

Correlation of myosin light chain phosphorylation with isometric contraction of fibroblasts.

1993 • 186 citations

Differences in the Regulation of Fibroblast Contraction of Floating Versus Stressed Collagen Matrices

1999 • 177 citations

Molecular cloning of a high-affinity receptor for the growth factor-like lipid mediator lysophosphatidic acid from Xenopus oocytes

1996 • 173 citations

The Biology of the Myofibroblast Relationship to Wound Contraction and Fibrocontractive Diseases

1988 • 156 citations

Protein phosphatase type-1, not type-2A, modulates actin microfilament integrity and myosin light chain phosphorylation in living nonmuscle cells.

1990 • 118 citations

Modulation of cell surface fibronectin assembly sites by lysophosphatidic acid.

1994 • 105 citations

Correlation of α-smooth muscle actin expression and contraction in Dupuytren's disease fibroblasts

1995 • 89 citations

Calcium dependence of myosin light chain phosphorylation in smooth muscle cells.

1988 • 89 citations

Angiogenesis in rat aorta ring explant cultures.

1989 • 80 citations

Pharmacologic regulation of Dupuytren's fibroblast contraction in vitro

1996 • 69 citations

Myosin II phosphorylation and the dynamics of stress fibers in serum-deprived and stimulated fibroblasts.

1992 • 52 citations

Thrombin Stimulates Fibroblast-Mediated Collagen Lattice Contraction by Its Proteolytically Activated Receptor

1994 • 39 citations

Growth Factor‐Like Action of Lysophosphatidic Acid: Mitogenic Signalling Mediated by G Proteins

2007 • 18 citations