Combining radiotherapy and immunotherapy: A revived partnership

Cancer immunoediting: from immunosurveillance to tumor escape

2002 • 4,911 citations

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Interleukin-12 and the regulation of innate resistance and adaptive immunity

2003 • 3,689 citations

Enhancement of Antitumor Immunity by CTLA-4 Blockade

1996 • 3,585 citations

Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells

1996 • 1,908 citations

Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo

2001 • 1,845 citations

Molecular identification of a danger signal that alerts the immune system to dying cells

2003 • 1,649 citations

Natural adjuvants: Endogenous activators of dendritic cells

1999 • 1,611 citations

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

1985 • 1,596 citations

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

2003 • 1,564 citations

Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity

1999 • 1,475 citations

Antigen-Specific Inhibition of Effector T Cell Function in Humans after Injection of Immature Dendritic Cells

2001 • 1,384 citations

Consequences of Cell Death

2000 • 1,382 citations

Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4

2002 • 1,339 citations

Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated

2004 • 1,253 citations

The Extra Domain A of Fibronectin Activates Toll-like Receptor 4

2001 • 1,200 citations

Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance

2002 • 1,176 citations

A p16 ^INK4a -Insensitive CDK4 Mutant Targeted by Cytolytic T Lymphocytes in a Human Melanoma

1995 • 1,147 citations

Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified.

1996 • 1,129 citations

Infusion of Cytotoxic T Cells for the Prevention and Treatment of Epstein-Barr Virus–Induced Lymphoma in Allogeneic Transplant Recipients

1998 • 1,103 citations

Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.

1999 • 1,066 citations

Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

2001 • 1,033 citations

Combination Immunotherapy of B16 Melanoma Using Anti–Cytotoxic T Lymphocyte–Associated Antigen 4 (Ctla-4) and Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf)-Producing Vaccines Induces Rejection of Subcutaneous and Metastatic Tumors Accompanied by Autoimmune Depigmentation

1999 • 1,000 citations

Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients

2003 • 981 citations

Fibrinogen Stimulates Macrophage Chemokine Secretion Through Toll-Like Receptor 4

2001 • 947 citations

Immune-Mediated Inhibition of Metastases after Treatment with Local Radiation and CTLA-4 Blockade in a Mouse Model of Breast Cancer

2005 • 940 citations

CTLA-4: new insights into its biological function and use in tumor immunotherapy

2002 • 923 citations

A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes

2000 • 908 citations

DEGRADATION OF CELL PROTEINS AND THE GENERATION OF MHC CLASS I-PRESENTED PEPTIDES

1999 • 898 citations

Cancer/testis antigens: an expanding family of targets for cancer immunotherapy

2002 • 851 citations

A listing of human tumor antigens recognized by T cells

2001 • 708 citations

Specific T Helper Cell Requirement for Optimal Induction of Cytotoxic T Lymphocytes against Major Histocompatibility Complex Class II Negative Tumors

1998 • 611 citations

Cancer Immunotherapy: A Treatment for the Masses

2004 • 610 citations

Recognition of microbial infection by Toll-like receptors

2003 • 556 citations

Sublethal Irradiation of Human Tumor Cells Modulates Phenotype Resulting in Enhanced Killing by Cytotoxic T Lymphocytes

2004 • 532 citations

Generation of Human Cytotoxic T Cells Specific for Human Carcinoembryonic Antigen Epitopes From Patients Immunized With Recombinant Vaccinia-CEA Vaccine

1995 • 506 citations

Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors

2002 • 491 citations

Increased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiation.

1989 • 473 citations

A listing of human tumor antigens recognized by T cells: March 2004 update

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Irradiation of Tumor Cells Up-Regulates Fas and Enhances CTL Lytic Activity and CTL Adoptive Immunotherapy

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Induction of Tumor Cell Apoptosis In Vivo Increases Tumor Antigen Cross-Presentation, Cross-Priming Rather than Cross-Tolerizing Host Tumor-Specific CD8 T Cells

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Decreased antigen presentation by dendritic cells in patients with breast cancer.

1997 • 439 citations

Cross-presentation by intercellular peptide transfer through gap junctions

2005 • 430 citations

External Beam Radiation of Tumors Alters Phenotype of Tumor Cells to Render Them Susceptible to Vaccine-Mediated T-Cell Killing

2004 • 425 citations

Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors

2002 • 424 citations

Melanocyte Destruction after Antigen-Specific Immunotherapy of Melanoma

2000 • 423 citations

Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade.

2000 • 421 citations

CTLA-4 blockade synergizes with tumor-derived granulocyte– macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma

1998 • 375 citations

Combining a Recombinant Cancer Vaccine with Standard Definitive Radiotherapy in Patients with Localized Prostate Cancer

2005 • 373 citations

Bystander apoptosis triggers dendritic cell maturation and antigen-presenting function.

1998 • 353 citations

Manipulating dendritic cell biology for the active immunotherapy of cancer

2004 • 346 citations

Induction of acute phase gene expression by brain irradiation

1995 • 338 citations

Dendritic Cells Acquire Antigens from Live Cells for Cross-Presentation to CTL

2001 • 318 citations

A Sense of Danger from Radiation¹

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Targeting p53 as a general tumor antigen.

1995 • 315 citations

Flt3 ligand induces tumor regression and antitumor immune responses in vivo

1997 • 315 citations

Workshop R: Tumor Immunology, Abstract R1 bis R30

2001 • 312 citations

Immature myeloid cells and cancer-associated immune suppression

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Cell adhesion molecules mediate radiation-induced leukocyte adhesion to the vascular endothelium.

1996 • 296 citations

Cutting Edge: Bystander Apoptosis Triggers Dendritic Cell Maturation and Antigen-Presenting Function

1998 • 295 citations

Immunogenicity of Apoptotic Cells In Vivo: Role of Antigen Load, Antigen-Presenting Cells, and Cytokines

1999 • 295 citations

Mechanisms of Exogenous Antigen Presentation by MHC Class I Molecules in Vitro and in Vivo: Implications for Generating CD8+ T Cell Responses to Infectious Agents, Tumors, Transplants, and Vaccines

1999 • 293 citations

Prostaglandin E2 and Tumor Necrosis Factor α Cooperate to Activate Human Dendritic Cells: Synergistic Activation of Interleukin 12 Production

1997 • 281 citations

Tumor Eradication by Adoptive Transfer of Cytototic T Lymphocytes

1992 • 281 citations

MUC‐1 Epithelial Tumor Mucin‐Based Immunity and Cancer Vaccines

1995 • 267 citations

Cell-Associated Ovalbumin Is Cross-Presented Much More Efficiently than Soluble Ovalbumin In Vivo

2001 • 260 citations

The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules

2004 • 256 citations

Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein

2001 • 251 citations

Contrasting frequencies of antitumor and anti-vaccine T cells in metastases of a melanoma patient vaccinated with a MAGE tumor antigen

2005 • 243 citations

Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses

2000 • 227 citations

Antitumor Vaccination of Patients With Glioblastoma Multiforme: A Pilot Study to Assess Feasibility, Safety, and Clinical Benefit

2004 • 211 citations

Flt3-ligand administration after radiation therapy prolongs survival in a murine model of metastatic lung cancer.

1999 • 211 citations

Phase I study of a MUC1 vaccine composed of different doses of MUC1 peptide with SB-AS2 adjuvant in resected and locally advanced pancreatic cancer

2004 • 203 citations

Comparative analysis of necrotic and apoptotic tumor cells as a source of antigen(s) in dendritic cell-based immunization.

2001 • 202 citations

Antitumor applications of stimulating toll-like receptor 9 with CpG oligodeoxynucleotides

2004 • 201 citations

Immune Modulation by Ionizing Radiation and its Implications for Cancer Immunotherapy

2002 • 200 citations

TNFerade Biologic, an Adenovector With a Radiation-Inducible Promoter, Carrying the Human Tumor Necrosis Factor Alpha Gene: A Phase I Study in Patients With Solid Tumors

2004 • 197 citations

Enhanced induction of antitumor T-cell responses by cytotoxic T lymphocyte-associated molecule-4 blockade: the effect is manifested only at the restricted tumor-bearing stages.

1997 • 197 citations

Dendritic cells resurrect antigens from dead cells

2001 • 192 citations

Cellular protein is the source of cross-priming antigenin vivo

2004 • 190 citations

First-line, single-agent Herceptin® (trastuzumab) in metastatic breast cancer

2001 • 185 citations

Rapid induction of cytokine gene expression in the lung after single and fractionated doses of radiation

1999 • 162 citations

Radiotherapy potentiates the therapeutic efficacy of intratumoral dendritic cell administration.

2003 • 158 citations

Natural endogenous adjuvants

2004 • 154 citations

Targeting Toll-like Receptor 9 with CpG Oligodeoxynucleotides Enhances Tumor Response to Fractionated Radiotherapy

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Tolerance to Islet Antigens and Prevention from Diabetes Induced by Limited Apoptosis of Pancreatic β Cells

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CpG Oligodeoxynucleotide Enhances Tumor Response to Radiation

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Gene therapy targeted by radiation preferentially radiosensitizes tumor cells.

1994 • 143 citations

Integrin-mediated targeting of drug delivery to irradiated tumor blood vessels

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2001 • 131 citations

Molecular mechanisms of ionizing radiation‐induced apoptosis

1999 • 130 citations

Antigens derived from melanocyte differentiation proteins: self‐tolerance, autoimmunity, and use for cancer immunotherapy

2002 • 130 citations

Up-regulation of Fas (CD95) in human p53wild-type cancer cells treated with ionizing radiation

1997 • 128 citations

Cytotoxic T Cells Isolated from Ovarian Malignant Ascites Recognize a Peptide Derived from the HER-2/neu Proto-oncogene

1993 • 124 citations

Radiation induces upregulation of cyclooxygenase-2 (COX-2) protein in PC-3 cells

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Immunity to oncogenic human papillomaviruses

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Induction of the Expression of the Interleukin-1β Gene in Mouse Spleen by Ionizing Radiation

1993 • 91 citations

Cancer vaccines: progress reveals new complexities

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Direct injection of immature dendritic cells into irradiated tumor induces efficient antitumor immunity

2004 • 82 citations

Accumulation of P-Selectin in the Lumen of Irradiated Blood Vessels

1999 • 79 citations

TNFerade Biologic: Preclinical toxicology of a novel adenovector with a radiation-inducible promoter, carrying the human tumor necrosis factor alpha gene

2002 • 79 citations

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Current developments of immunotherapy in the clinic

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Cancer vaccines: progress reveals new complexities

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X-ray-induced P-selectin localization to the lumen of tumor blood vessels.

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γ‐Ray irradiation induces B7.1 expression in myeloid leukaemic cells

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Select forms of tumor cell apoptosis induce dendritic cell maturation

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In vivo tracking of tumor-specific T cells

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Local tumor irradiation augments the antitumor effect of cytokine-producing autologous cancer cell vaccines in a murine glioma model

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Tumor immunity meets autoimmunity: antigen levels and dendritic cell maturation

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The effect of irradiation on expression of HLA class I antigens in human brain tumors in culture

1994 • 56 citations

Phase I dose-escalation study of tumor necrosis factor-alpha and concomitant radiation therapy.

1995 • 55 citations

Combination Treatment of Murine Tumors by Adenovirus-Mediated Local B7/IL12 Immunotherapy and Radiotherapy

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Enhanced eradication of local and distant tumors by genetically produced interleukin-12 and radiation.

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IL‐3 in the Clinic

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Ionizing radiation as a response‐enhancing agent for CD95‐mediated apoptosis

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Intratumoral Administration of Low Doses of an Adenovirus Vector Encoding Tumor Necrosis FactorαTogether with Naive Dendritic Cells Elicits Significant Suppression of Tumor Growth without Toxicity

2001 • 38 citations

CTL: Caspases Terminate Life, but that's not the whole story

2002 • 37 citations

Combining radiation therapy with interleukin-3 gene immunotherapy

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Effects of Irradiation on the Expression of Surface Antigens in Human Ovarian Cancer

1996 • 36 citations

Irradiated tumor cell vaccine for treatment of an established glioma. I. Successful treatment with combined radiotherapy and cellular vaccination

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Adenoviral interleukin-3 gene-radiation therapy for prostate cancer in mouse model

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Ionizing radiation modulates the exposure of the HUIV26 cryptic epitope within collagen type IV during angiogenesis

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Radiation‐induced leukocyte adhesion to endothelium in normal pancreas and in pancreatic carcinoma of the rat

2003 • 16 citations

Tumor-Specific Responses in Lymph Nodes Draining Murine Sarcomas Are Concentrated in Cells Expressing P-Selectin Binding Sites

2001 • 16 citations