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Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

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1994 • 1,047 citations

TNF? and the TNF receptor superfamily: Structure-function relationship(s)

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In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium

1992 • 953 citations

Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis

1994 • 829 citations

The two different receptors for tumor necrosis factor mediate distinct cellular responses.

1991 • 815 citations

Adenovirus-Mediated Transfer of a Recombinant α1-Antitrypsin Gene to the Lung Epithelium in Vivo

1991 • 743 citations

High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma.

1992 • 730 citations

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1992 • 601 citations

Evidence for the involvement of endotheliai cell integrin αVβ3 in the disruption of the tumor vascuiature induced by TNF and IFN-γ

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1997 • 432 citations

Dendritic Cells Genetically Modified with an Adenovirus Vector Encoding the cDNA for a Model Antigen Induce Protective and Therapeutic Antitumor Immunity

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Studies on the anti-tumor efficacy of systemically administered recombinant tumor necrosis factor against several murine tumors in vivo.

1987 • 292 citations

Estimation of liver tumor volume using different formulas?An experimental study in rats

1983 • 286 citations

Murine tumor cells transduced with the gene for tumor necrosis factor-alpha. Evidence for paracrine immune effects of tumor necrosis factor against tumors.

1991 • 283 citations

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1991 • 279 citations

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1993 • 221 citations

A phase I trial of intravenously-administered recombinant tumor necrosis factor-alpha in cancer patients.

1988 • 220 citations

Clinical pharmacology of recombinant human tumor necrosis factor in patients with advanced cancer.

1987 • 216 citations

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1986 • 211 citations

Isolated hepatic perfusion with tumor necrosis factor and melphalan for unresectable cancers confined to the liver.

1998 • 187 citations

Regional Suppression of Tumor Growth byIn VivoTransfer of a cDNA Encoding a Secreted Form of the Extracellular Domain of theflt-1Vascular Endothelial Growth Factor Receptor

1998 • 182 citations

Human TNF mutants with selective activity on the p55 receptor

1993 • 182 citations

Modulation of gene expression after replication-deficient, recombinant adenovirus-mediated gene transfer by the product of a second adenovirus vector.

1995 • 149 citations

Harly endothelium activation and polymorphonuclear cell invasion precede specific necrosis of human melanoma and sarcoma treated by intravascular high‐dose tumour necrosis factor alpha (rTNFα)

1994 • 149 citations

Dendritic cells modified to express CD40 ligand elicit therapeutic immunity against preexisting murine tumors

2000 • 142 citations

Tumor necrosis factor alpha-induced leukocyte adhesion in normal and tumor vessels: effect of tumor type, transplantation site, and host strain.

1995 • 127 citations

Synergistic enhancement by tumor necrosis factor of in vitro cytotoxicity from chemotherapeutic drugs targeted at DNA topoisomerase II.

1987 • 116 citations

Functional activities of receptors for tumor necrosis factor-alpha on human vascular endothelial cells

1994 • 106 citations

Tumor necrosis factor alpha (TNF-alpha) gene therapy targeted by ionizing radiation selectively damages tumor vasculature.

1996 • 105 citations

Cytokine levels and systemic toxicity in patients undergoing isolated limb perfusion with high-dose tumor necrosis factor, interferon gamma, and melphalan.

1995 • 103 citations

Anti-Tumor Immunity Induced by in Vivo Adenovirus Vector-Mediated Expression of CD40 Ligand in Tumor Cells

1999 • 91 citations

Complete regression of established murine hepatocellular carcinoma by in vivo tumor necrosis factor alpha gene transfer

1997 • 85 citations

A Phase I trial of continuous hyperthermic peritoneal perfusion with tumor necrosis factor and cisplatin in the treatment of peritoneal carcinomatosis

1998 • 83 citations

Crucial Role of TNF-α in CD8 T Cell-Mediated Elimination of 3LL-A9 Lewis Lung Carcinoma Cells In Vivo

2000 • 73 citations

Tumor necrosis factor-alpha-based gene therapy enhances radiation cytotoxicity in human prostate cancer.

1999 • 72 citations

Tumour immunotherapy using an adenoviral vector expressing a membrane-bound mutant of murine TNFα

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Augmentation of antitumor efficacy by the combination of recombinant tumor necrosis factor and chemotherapeutic agents in vivo.

1989 • 67 citations

Tumor necrosis factor-alpha-induced apoptosis in prostate cancer cells through inhibition of nuclear factor-kappaB by an IkappaBalpha "super-repressor".

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Efficient adenoviral transfer of NF-?B inhibitor sensitizes melanoma to tumor necrosis factor-mediated apoptosis

1999 • 58 citations

Tumor necrosis factor as an antineoplastic agent: pitfalls and promises

1998 • 55 citations

Isolated Hypoxic Hepatic Perfusion With Tumor Necrosis Factor-Alpha, Melphalan, and Mitomycin C Using Balloon Catheter Techniques

1998 • 43 citations

A novel recombinant fusion toxin targeting HER-2/NEU-over-expressing cells and containing human tumor necrosis factor

2000 • 42 citations

Tumour therapy in mice using adenovirus vectors expressing human TNFa.

1998 • 42 citations

Adenovirus-mediated TNF-α Gene Transfer induces Significant Tumor Regression in Mice

1999 • 37 citations

Gene transfer of human TNFα into glioblastoma cells permits modulation of mdr1 expression and potentiation of chemosensitivity

1995 • 34 citations

Suppression of in vivo tumorigenicity of human lung cancer cells by retrovirus-mediated transfer of the human tumor necrosis factor-alpha cDNA.

1994 • 30 citations

An apoptosis-inducing gene therapy for pancreatic cancer with a combination of 55-kDa tumor necrosis factor (TNF) receptor gene transfection and mutein TNF administration.

1998 • 30 citations

Clinical and biologic effects of combination therapy with gamma-interferon and tumor necrosis factor

1992 • 29 citations

mdr1 promoter-driven tumor necrosis factor-α expression for a chemotherapy-controllable combined in vivo gene therapy and chemotherapy of tumors

2000 • 29 citations

Retroviral vector-mediated transfer of the tumor necrosis factor alpha gene into human cancer cells restores an apoptotic cell death program and induces a bystander-killing effect

1996 • 28 citations

Administration of high-dose tumor necrosis factor alpha by isolation perfusion of the limbs. Rationale and results.

1995 • 26 citations

Adenovirus-mediated wild-type-p53-gene expression sensitizes TNF-resistant tumor cells to TNF-induced cytotoxicity by altering the cellular redox state

2000 • 25 citations

Combinational immunotherapy for established tumors with engineered tumor vaccines and adenovirus-mediated gene transfer

2000 • 23 citations

Efficacy of tnf‐α gene‐transduced tumor cells in treatment of established in vivo tumor

1995 • 21 citations

Activated Dendritic Cells From Bone Marrow Cells of Mice Receiving Cytokine-Expressing Tumor Cells Are Associated With the Enhanced Survival of Mice Bearing Syngeneic Tumors

1999 • 19 citations

A p75 tumor necrosis factor receptor-specific mutant of murine tumor necrosis factor α expressed from an adenovirus vector induces an antitumor response with reduced toxicity

1999 • 18 citations

A model using radiation and plasmid-mediated tumor necrosis factor-alpha gene therapy for treatment of glioblastomas.

2000 • 18 citations

Use of soluble recombinant TNF receptor to improve detection of TNF secretion in cultures of tumor infiltrating lymphocytes

1992 • 9 citations