Tolerance to Islet Antigens and Prevention from Diabetes Induced by Limited Apoptosis of Pancreatic β Cells

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

Dendritic Cells

2001 • 2,164 citations

Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo

2001 • 1,845 citations

Regulatory T Cells

2000 • 1,827 citations

Determination of lymphocyte division by flow cytometry

1994 • 1,712 citations

Natural adjuvants: Endogenous activators of dendritic cells

1999 • 1,611 citations

Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells

2000 • 1,577 citations

Antigen-Specific Inhibition of Effector T Cell Function in Humans after Injection of Immature Dendritic Cells

2001 • 1,384 citations

Consequences of Cell Death

2000 • 1,382 citations

Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

1985 • 1,292 citations

Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

1998 • 1,226 citations

A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes

2000 • 908 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

Following a diabetogenic T cell from genesis through pathogenesis

1993 • 708 citations

The Nonobese Diabetic Mouse as a Model of Autoimmune Diabetes: Immune Dysregulation Gets the NOD

1997 • 685 citations

Efficient Presentation of Phagocytosed Cellular Fragments on the Major Histocompatibility Complex Class II Products of Dendritic Cells

1998 • 649 citations

Constitutive class I-restricted exogenous presentation of self antigens in vivo.

1996 • 637 citations

Fas- and Tumor Necrosis Factor-induced Apoptosis Is Inhibited by the Poxvirus crmA Gene Product

1995 • 604 citations

Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.

1987 • 576 citations

Differentiation of T Regulatory Cells by Immature Dendritic Cells

2001 • 500 citations

Adoptive Transfer of Diabetes Into Immunodeficient NOD-scid/scid Mice: Relative Contributions of CD4+ and CD8+ T-Cells From Diabetic Versus Prediabetic NOD.NON-Thy-1a Donors

1993 • 431 citations

Acceleration of Diabetes in Young Nod Mice with a CD4 ⁺ Islet-specific T Cell Clone

1990 • 385 citations

β cell apoptosis in T cell-mediated autoimmune diabetes

1997 • 330 citations

Major Histocompatibility Complex Class I–restricted Cross-presentation Is Biased towards High Dose Antigens and Those Released during Cellular Destruction

1998 • 323 citations

A role for CD36 in the regulation of dendritic cell function

2001 • 315 citations

How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model

1994 • 309 citations

CD4+ T Cell Tolerance to Parenchymal Self-Antigens Requires Presentation by Bone Marrow–derived Antigen-presenting Cells

1998 • 300 citations

Neonatal beta-cell apoptosis: a trigger for autoimmune diabetes?

2000 • 292 citations

The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency.

1992 • 274 citations

The selective engulfment of apoptotic bodies by dendritic cells is mediated by the αvβ3 integrin and requires intracellular and extracellular calcium

1997 • 262 citations

CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose

1999 • 245 citations

Cross-tolerance: A Pathway for Inducing Tolerance to Peripheral Tissue Antigens

1998 • 216 citations

Identification of MHC Class II-Restricted Peptide Ligands, Including a Glutamic Acid Decarboxylase 65 Sequence, that Stimulate Diabetogenic T Cells from Transgenic BDC2.5 Nonobese Diabetic Mice

2001 • 213 citations

Apoptosis Is the Mode of β-Cell Death Responsible for the Development of IDDM in the Nonobese Diabetic (NOD) Mouse

1997 • 203 citations

BETA-CELL APOPTOSIS IS RESPONSIBLE FOR THE DEVELOPMENT OF IDDM IN THE MULTIPLE LOW-DOSE STREPTOZOTOCIN MODEL

1996 • 181 citations

Multiple low-dose streptozotocin-induced hyperglycemia and insulitis in C57BL mice: Influence of inbred background, sex, and thymus

1982 • 177 citations

Self‐Ignorance in the Peripheral T‐Cell Pool

1993 • 124 citations

Limited capacity for tolerization of CD4+ T cells specific for a pancreatic β cell neo-antigen

1995 • 121 citations

Evidence that beta cell death in the nonobese diabetic mouse is Fas independent.

1999 • 114 citations

NK T Cell-Induced Protection Against Diabetes in Vα14-Jα281 Transgenic Nonobese Diabetic Mice Is Associated with a Th2 Shift Circumscribed Regionally to the Islets and Functionally to Islet Autoantigen

2001 • 113 citations

Islet cell analysis and purification by light scatter and autofluorescence

1982 • 97 citations

Evidence That β Cell Death in the Nonobese Diabetic Mouse Is Fas Independent

1999 • 89 citations

Peripheral tolerance of CD4 T cells following local activation in adolescent mice

1996 • 82 citations

Pancreatic islet beta cells drive T cell-immune responses in the nonobese diabetic mouse model.

1995 • 75 citations

Selective immunomodulation by the autoimmunity-inducing xenobiotics streptozotocin and HgCl2

1998 • 34 citations

Establishment and Characterization of RAG‐2 Deficient Non‐Obese Diabetic Mice

1996 • 30 citations

Death, destruction, danger and dendritic cells

1999 • 26 citations

T Cell-Dependent Class II Major Histocompatibility Complex Antigen Expression in vivo Induced by the Diabotegen Streptozotocin

1989 • 7 citations