Dendritic cells resurrect antigens from dead cells

Dendritic cells and the control of immunity

1998 • 14,345 citations

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

1998 • 3,085 citations

Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells

1998 • 2,916 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes

1998 • 2,078 citations

Natural adjuvants: Endogenous activators of dendritic cells

1999 • 1,611 citations

Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells

2000 • 1,577 citations

Antigen-Specific Inhibition of Effector T Cell Function in Humans after Injection of Immature Dendritic Cells

2001 • 1,384 citations

Consequences of Cell Death

2000 • 1,382 citations

Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway

2000 • 1,299 citations

Cd8+ but Not Cd8− Dendritic Cells Cross-Prime Cytotoxic T Cells in Vivo

2000 • 1,286 citations

Vaccination with Mage-3a1 Peptide–Pulsed Mature, Monocyte-Derived Dendritic Cells Expands Specific Cytotoxic T Cells and Induces Regression of Some Metastases in Advanced Stage IV Melanoma

1999 • 1,260 citations

Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

1998 • 1,226 citations

Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

1994 • 1,185 citations

Fundamental Immunology

1999 • 1,011 citations

Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.

1976 • 951 citations

A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes

2000 • 908 citations

Fcγ Receptor–mediated Induction of Dendritic Cell Maturation and Major Histocompatibility Complex Class I–restricted Antigen Presentation after Immune Complex Internalization

1999 • 898 citations

A Mechanism for the Specific Immunogenicity of Heat Shock Protein-Chaperoned Peptides

1995 • 838 citations

A Hierarchical Role for Classical Pathway Complement Proteins in the Clearance of Apoptotic Cells in Vivo

2000 • 733 citations

Induction of a CD8+ Cytotoxic T Lymphocyte Response by Cross-priming Requires Cognate CD4+ T Cell Help

1997 • 729 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

CD91: a receptor for heat shock protein gp96

2000 • 673 citations

Efficient Presentation of Phagocytosed Cellular Fragments on the Major Histocompatibility Complex Class II Products of Dendritic Cells

1998 • 649 citations

Constitutive class I-restricted exogenous presentation of self antigens in vivo.

1996 • 637 citations

Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages.

1993 • 592 citations

Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen

1999 • 586 citations

Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells

1999 • 564 citations

Heat Shock Proteins Come of Age: Primitive Functions Acquire New Roles in an Adaptive World

1998 • 560 citations

In vitro cell-mediated immune responses to the male specific(H-Y) antigen in mice.

1975 • 454 citations

Tumor-specific killer cells in paraneoplastic cerebellar degeneration

1998 • 449 citations

Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages

1995 • 416 citations

αvβ5 integrin recruits the CrkII–Dock180–Rac1 complex for phagocytosis of apoptotic cells

2000 • 375 citations

Inhibition of dendritic cell maturation by herpes simplex virus

1999 • 369 citations

Bystander apoptosis triggers dendritic cell maturation and antigen-presenting function.

1998 • 353 citations

Human Cd4+ T Lymphocytes Consistently Respond to the Latent Epstein-Barr Virus Nuclear Antigen Ebna1

2000 • 340 citations

Heat Shock Protein 70 Induced During Tumor Cell Killing Induces Th1 Cytokines and Targets Immature Dendritic Cell Precursors to Enhance Antigen Uptake

1999 • 332 citations

Major Histocompatibility Complex Class I–restricted Cross-presentation Is Biased towards High Dose Antigens and Those Released during Cellular Destruction

1998 • 323 citations

Immunogenicity of Apoptotic Cells In Vivo: Role of Antigen Load, Antigen-Presenting Cells, and Cytokines

1999 • 295 citations

Cutting Edge: Bystander Apoptosis Triggers Dendritic Cell Maturation and Antigen-Presenting Function

1998 • 295 citations

Mechanisms of Exogenous Antigen Presentation by MHC Class I Molecules in Vitro and in Vivo: Implications for Generating CD8+ T Cell Responses to Infectious Agents, Tumors, Transplants, and Vaccines

1999 • 293 citations

Processing of engulfed apoptotic bodies yields T cell epitopes.

1997 • 267 citations

Salmonella-Induced Apoptosis of Infected Macrophages Results in Presentation of a Bacteria-Encoded Antigen after Uptake by Bystander Dendritic Cells

2000 • 248 citations

A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production.

1996 • 238 citations

In Vivo Cross-Priming of MHC Class I–Restricted Antigens Requires the TAP Transporter

1996 • 225 citations

Generation of tumor-specific T-lymphocytes by cross-priming with human dendritic cells ingesting apoptotic tumor cells.

2000 • 222 citations

Cd40-Independent Pathways of T Cell Help for Priming of Cd8+ Cytotoxic T Lymphocytes

2000 • 201 citations

Antigen Concentration and Precursor Frequency Determine the Rate of CD8+ T Cell Tolerance to Peripherally Expressed Antigens

1999 • 174 citations

Dendritic cells containing apoptotic melanoma cells prime human CD8+ T cells for efficient tumor cell lysis.

2000 • 162 citations

Thymocytes appear to ignore class I major histocompatibility complex antigens expressed on thymus epithelial cells

1984 • 158 citations

Building better vaccines: how apoptotic cell death can induce inflammation and activate innate and adaptive immunity

2000 • 153 citations

Mature dendritic cells pulsed with freeze–thaw cell lysates define an effective in vitro vaccine designed to elicit EBV-specific CD4+ and CD8+ T lymphocyte responses

2000 • 152 citations

Dendritic cells acquire the MAGE-3 human tumor antigen from apoptotic cells and induce a class I-restricted T cell response

2000 • 152 citations

Requirement of Mature Dendritic Cells for Efficient Activation of Influenza A-Specific Memory CD8+ T Cells

2000 • 140 citations

Bone Marrow–Derived Antigen-Presenting Cells Are Required for the Generation of Cytotoxic T Lymphocyte Responses to Viruses and Use Transporter Associated with Antigen Presentation (Tap)-Dependent and -Independent Pathways of Antigen Presentation

2000 • 138 citations

Exogenous antigens gain access to the major histocompatibility complex class I processing pathway in B cells by receptor-mediated uptake.

1996 • 111 citations

Canarypox Virus-Induced Maturation of Dendritic Cells Is Mediated by Apoptotic Cell Death and Tumor Necrosis Factor Alpha Secretion

2000 • 111 citations

Requirements for Bone Marrow–Derived Antigen-Presenting Cells in Priming Cytotoxic T Cell Responses to Intracellular Pathogens

2000 • 99 citations

H-2 antigen requirements in the in vitro induction of SV40-specific cytotoxic T lymphocytes.

1980 • 86 citations

Dendritic cell/macrophage precursors capture exogenous antigen for MHC class I presentation by dendritic cells

1998 • 82 citations

Neonatal Tumor Necrosis Factor α Promotes Diabetes in Nonobese Diabetic Mice by Cd154-Independent Antigen Presentation to Cd8+ T Cells

2000 • 69 citations

The macrophage haunted by cell ghosts: a pathogen grows

2000 • 53 citations

Cross-Presentation of Tumor Antigens to Effector T Cells Is Sufficient to Mediate Effective Immunotherapy of Established Intracranial Tumors

2000 • 45 citations

Active immunization of humans with dendritic cells.

2000 • 39 citations