Endoplasmic Reticulum Stress Regulator XBP-1 Contributes to Effector CD8+ T Cell Differentiation during Acute Infection

Signal integration in the endoplasmic reticulum unfolded protein response

2007 • 5,948 citations

Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

1995 • 5,025 citations

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

2001 • 3,799 citations

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

2002 • 2,702 citations

Mediators of endoplasmic reticulum stress‐induced apoptosis

2006 • 2,212 citations

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

2003 • 1,979 citations

Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells

2003 • 1,790 citations

Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor

2007 • 1,712 citations

Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

2007 • 1,375 citations

IRE1 Signaling Affects Cell Fate During the Unfolded Protein Response

2007 • 1,292 citations

Plasma cell differentiation requires the transcription factor XBP-1

2001 • 1,256 citations

Effector and Memory CTL Differentiation

2006 • 908 citations

From acute ER stress to physiological roles of the Unfolded Protein Response

2006 • 850 citations

Selective Stimulation of T Cell Subsets with Antibody-Cytokine Immune Complexes

2006 • 843 citations

Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

2003 • 843 citations

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1998 • 800 citations

XBP1 Controls Diverse Cell Type- and Condition-Specific Transcriptional Regulatory Networks

2007 • 795 citations

Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells

2006 • 770 citations

Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates

2008 • 616 citations

Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

2003 • 597 citations

Estimating the Precursor Frequency of Naive Antigen-specific CD8 T Cells

2002 • 584 citations

An essential role in liver development for transcription factor XBP-1

2000 • 503 citations

A transgenic mouse model for monitoring endoplasmic reticulum stress

2003 • 452 citations

XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands

2005 • 437 citations

pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response

2006 • 405 citations

Viruses, endoplasmic reticulum stress, and interferon responses

2006 • 400 citations

RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.

1993 • 393 citations

That which does not kill me makes me stronger: adapting to chronic ER stress

2007 • 387 citations

Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo

2003 • 384 citations

Organ-Specific Regulation of the CD8 T Cell Response toListeria monocytogenesInfection

2001 • 382 citations

The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis

2005 • 302 citations

Immunosuppression and Resultant Viral Persistence by Specific Viral Targeting of Dendritic Cells

2000 • 283 citations

The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis

2005 • 280 citations

The transcription factor XBP-1 is essential for the development and survival of dendritic cells

2007 • 279 citations

Distinct IL-2 Receptor Signaling Pattern in CD4+CD25+ Regulatory T Cells

2004 • 279 citations

Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells

2007 • 273 citations

Viral Infections Induce Abundant Numbers of Senescent CD8 T Cells

2001 • 236 citations

IL-2 Is Not Required for the Initiation of CD8 T Cell Cycling but Sustains Expansion

2003 • 232 citations

Immunological adjuvants promote activated T cell survival via induction of Bcl-3

2001 • 228 citations

Hepatitis C Virus Suppresses the IRE1-XBP1 Pathway of the Unfolded Protein Response

2004 • 220 citations

Differential role of IL‐2R signaling for CD8⁺ T cell responses in acute and chronic viral infections

2007 • 179 citations

Shortening the Infectious Period Does Not Alter Expansion of CD8 T Cells but Diminishes Their Capacity to Differentiate into Memory Cells

2004 • 159 citations

The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cells

2007 • 128 citations

Stressed-out B cells? Plasma-cell differentiation and the unfolded protein response

2003 • 121 citations

Notch-Regulated Ankyrin-Repeat Protein Inhibits Notch1 Signaling: Multiple Notch1 Signaling Pathways Involved In T Cell Development

2003 • 116 citations

Quantitating the Magnitude of the Lymphocytic Choriomeningitis Virus-Specific CD8 T-Cell Response: It Is Even Bigger than We Thought

2006 • 109 citations

Naive CD8+ T cells differentiate into protective memory-like cells after IL-2–anti–IL-2 complex treatment in vivo

2007 • 108 citations

Analysis of γc-Family Cytokine Target Genes

2003 • 95 citations

DNA array analysis of interleukin-2-regulated immediate/early genes.

2002 • 81 citations

XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells

2005 • 74 citations

IL-2 In Vivo Activities and Antitumor Efficacy Enhanced by an Anti-IL-2 mAb

2006 • 66 citations

Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes

2005 • 53 citations