Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

1995 • 93,704 citations

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

The Sequence of the Human Genome

2001 • 13,500 citations

The Human Genome Browser at UCSC

2002 • 9,920 citations

<tt>BLAT</tt>—The <tt>BLAST</tt>-Like Alignment Tool

2002 • 8,153 citations

The TNF and TNF Receptor Superfamilies

2001 • 3,533 citations

Exploring the new world of the genome with DNA microarrays

1999 • 2,454 citations

Variance stabilization applied to microarray data calibration and to the quantification of differential expression

2002 • 2,340 citations

The UCSC Genome Browser Database

2003 • 1,872 citations

Protein Tyrosine Phosphatases in the Human Genome

2004 • 1,842 citations

Regulatory T Cells

2000 • 1,827 citations

JAKS AND STATS: Biological Implications

1998 • 1,788 citations

Expression profiling using cDNA microarrays

1999 • 1,689 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Large-scale analysis of the human and mouse transcriptomes

2002 • 1,493 citations

Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses

1998 • 1,316 citations

The cytokine handbook

1994 • 1,121 citations

Stat5a is mandatory for adult mammary gland development and lactogenesis.

1997 • 1,106 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off

1998 • 989 citations

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

1997 • 989 citations

MATURE T LYMPHOCYTE APOPTOSIS—Immune Regulation in a Dynamic and Unpredictable Antigenic Environment

1999 • 973 citations

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

1995 • 868 citations

Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

1998 • 843 citations

Dual specificity phosphatases: a gene family for control of MAP kinase function

2000 • 791 citations

INTERNATIONAL HUMAN GENOME SEQUENCING CONSORTIUM. INITIAL SEQUENCING AND ANALYSIS OF THE HUMAN GENOME

2001 • 790 citations

The Human Transcriptome Map: Clustering of Highly Expressed Genes in Chromosomal Domains

2001 • 736 citations

Biochemical Mechanisms of IL-2–Regulated Fas-Mediated T Cell Apoptosis

1998 • 644 citations

Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome

2002 • 619 citations

Suppressors of cytokine signaling and immunity

2003 • 607 citations

Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death.

1995 • 574 citations

Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells

1999 • 554 citations

Clustering of housekeeping genes provides a unified model of gene order in the human genome

2002 • 551 citations

CIS, a Cytokine Inducible SH2 Protein, Is a Target of the JAK-STAT5 Pathway and Modulates STAT5 Activation

1997 • 538 citations

A computational analysis of whole-genome expression data reveals chromosomal domains of gene expression

2000 • 532 citations

Evidence for large domains of similarly expressed genes in the Drosophila genome

2002 • 483 citations

A variance-stabilizing transformation for gene-expression microarray data

2002 • 460 citations

Inhibitors of Cytokine Signal Transduction

2004 • 440 citations

The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity

2000 • 440 citations

Chromosomal clustering of muscle-expressed genes in Caenorhabditis elegans

2002 • 414 citations

Human immune disorder arising from mutation of the α chain of the interleukin-2 receptor

1997 • 402 citations

Genome-wide analysis of clustered Dorsal binding sites identifies putative target genes in the Drosophila embryo

2001 • 378 citations

Biomedical Discovery with DNA Arrays

2000 • 362 citations

A global analysis of Caenorhabditis elegans operons

2002 • 359 citations

Cytokines and immunodeficiency diseases: critical roles of the γ_c‐dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways

2004 • 357 citations

Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters

2004 • 352 citations

The Human Transcriptome Map Reveals Extremes in Gene Density, Intron Length, GC Content, and Repeat Pattern for Domains of Highly and Weakly Expressed Genes

2003 • 344 citations

Roles of STAT3 defined by tissue-specific gene targeting

2000 • 341 citations

Genomic Gene Clustering Analysis of Pathways in Eukaryotes

2003 • 334 citations

The main function of IL-2 is to promote the development of T regulatory cells

2003 • 323 citations

Stat5b Is Essential for Natural Killer Cell–mediated Proliferation and Cytolytic Activity

1998 • 323 citations

Large clusters of co-expressed genes in the Drosophila genome

2002 • 322 citations

MAP kinase phosphatases.

2002 • 311 citations

Comprehensive Analysis of Photoreceptor Gene Expression and the Identification of Candidate Retinal Disease Genes

2001 • 308 citations

Combining mapping and arraying: An approach to candidate gene identification

2002 • 304 citations

An Indirect Effect of Stat5a in IL-2–Induced Proliferation: A Critical Role for Stat5a in IL-2–Mediated IL-2 Receptor α Chain Induction

1997 • 275 citations

The identification of functional modules from the genomic association of genes

2002 • 251 citations

Toso, a Cell Surface, Specific Regulator of Fas-Induced Apoptosis in T Cells

1998 • 224 citations

Computational identification of developmental enhancers: conservation and function of transcription factor binding-site clusters in Drosophila melanogaster and Drosophila pseudoobscura.

2004 • 217 citations

Analysing uncharted transcriptomes with SAGE

2000 • 217 citations

Signaling by the TNF Receptor Superfamily and T Cell Homeostasis

2000 • 194 citations

Coexpression of Neighboring Genes in Caenorhabditis Elegans Is Mostly Due to Operons and Duplicate Genes

2003 • 194 citations

Gene expression analysis in schizophrenia: Reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22

2002 • 182 citations

The eukaryotic genome: a system regulated at different hierarchical levels

2003 • 180 citations

IL-2 negatively regulates IL-7 receptor α chain expression in activated T lymphocytes

2002 • 176 citations

The role of suppressor T cells in regulation of immune responses

2002 • 176 citations

T Cell Growth Cytokines Cause the Superinduction of Molecules Mediating Antigen-Induced T Lymphocyte Death

1998 • 141 citations

JAB/SOCS1/SSI-1 is an interleukin-2–induced inhibitor of IL-2 signaling

2001 • 140 citations

Gene Discovery Using the Serial Analysis of Gene Expression Technique: Implications for Cancer Research

2001 • 134 citations

Evolution of the interleukins

2003 • 100 citations

Analysis of γc-Family Cytokine Target Genes

2003 • 95 citations

DNA array analysis of interleukin-2-regulated immediate/early genes.

2002 • 81 citations

Impact of p53 knockout and topotecan treatment on gene expression profiles in human colon carcinoma cells: a pharmacogenomic study.

2003 • 80 citations

Hematopoietic Protein Tyrosine Phosphatase Suppresses Extracellular Stimulus-Regulated Kinase Activation

2001 • 66 citations

Interleukin-2 Signaling and the Maintenance of Self-Tolerance

2001 • 54 citations

The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP

2000 • 43 citations

Clustering of Tissue-Specific Genes Underlies Much of the Similarity in Rates of Protein Evolution of Linked Genes

2002 • 33 citations

Genome-wide transcriptome mapping analysis identifies organ-specific gene expression patterns along human chromosomes

2004 • 32 citations

Role of the common cytokine receptor γ chain (γc) in thymocyte selection

2000 • 21 citations

A comparative analysis of transcribed genes in the mouse hypothalamus and neocortex reveals chromosomal clustering

2004 • 19 citations

Interleukin-2

2003 • 11 citations

Mechanisms and Biological Consequences of STAT Signaling by Cytokines that Share the Common Cytokine Receptor γ Chain, γc

2003 • 3 citations