Mediators of endoplasmic reticulum stress‐induced apoptosis

Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

1995 • 5,025 citations

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

2001 • 3,799 citations

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

2003 • 3,079 citations

THE MAMMALIAN UNFOLDED PROTEIN RESPONSE

2005 • 2,964 citations

Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

2000 • 2,831 citations

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

2003 • 1,979 citations

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1998 • 1,972 citations

Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response

2000 • 1,933 citations

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

2004 • 1,854 citations

Gadd153 Sensitizes Cells to Endoplasmic Reticulum Stress by Down-Regulating Bcl2 and Perturbing the Cellular Redox State

2001 • 1,840 citations

A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress

2005 • 1,345 citations

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

2002 • 1,296 citations

Orchestrating the unfolded protein response in health and disease

2002 • 1,163 citations

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

2003 • 1,045 citations

Orchestrating the unfolded protein response in health and disease

2002 • 966 citations

TRB3, a novel ER stress-inducible gene, is induced via ATF4–CHOP pathway and is involved in cell death

2005 • 933 citations

Activation of Caspase-12, an Endoplastic Reticulum (ER) Resident Caspase, through Tumor Necrosis Factor Receptor-associated Factor 2-dependent Mechanism in Response to the ER Stress

2001 • 832 citations

TRB3: A tribbles Homolog That Inhibits Akt/PKB Activation by Insulin in Liver

2003 • 809 citations

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

1998 • 782 citations

Proapoptotic BAX and BAK Modulate the Unfolded Protein Response by a Direct Interaction with IRE1α

2006 • 642 citations

ASK1 Is Essential for JNK/SAPK Activation by TRAF2

1998 • 641 citations

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

2003 • 586 citations

Endoplasmic Reticulum Stress-induced Apoptosis

2006 • 490 citations

Caspase‐12 and ER‐Stress‐Mediated Apoptosis

2003 • 475 citations

Growth Arrest and DNA Damage-Inducible Protein GADD34 Targets Protein Phosphatase 1α to the Endoplasmic Reticulum and Promotes Dephosphorylation of the α Subunit of Eukaryotic Translation Initiation Factor 2

2003 • 374 citations

Gene expression during ER stress–induced apoptosis in neurons

2003 • 361 citations

Control of PERK eIF2α kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58 ^IPK

2002 • 360 citations

Execution of Apoptosis Signal-regulating Kinase 1 (ASK1)-induced Apoptosis by the Mitochondria-dependent Caspase Activation

2000 • 333 citations

Critical Role of Endogenous Akt/IAPs and MEK1/ERK Pathways in Counteracting Endoplasmic Reticulum Stress-induced Cell Death

2004 • 319 citations

Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells

1996 • 317 citations

Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice

2006 • 317 citations

Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2

2000 • 304 citations

Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis

2004 • 274 citations

P58IPK, a Novel Endoplasmic Reticulum Stress-inducible Protein and Potential Negative Regulator of eIF2α Signaling

2003 • 246 citations

Pancreatic β-Cell Failure and Diabetes in Mice With a Deletion Mutation of the Endoplasmic Reticulum Molecular Chaperone Gene P58IPK

2005 • 207 citations

Translocation of Bim to the Endoplasmic Reticulum (ER) Mediates ER Stress Signaling for Activation of Caspase-12 during ER Stress-induced Apoptosis

2004 • 187 citations

Leukemic HRX Fusion Proteins Inhibit GADD34-Induced Apoptosis and Associate with the GADD34 and hSNF5/INI1 Proteins

1999 • 159 citations

The modification and assembly of proteins in the endoplasmic reticulum

1993 • 156 citations

JAB1 participates in unfolded protein responses by association and dissociation with IRE1

2004 • 77 citations

Bcl-2 acts subsequent to and independent of Ca2+ fluxes to inhibit apoptosis in thapsigargin- and glucocorticoidmtreated mouse lymphoma cells

1996 • 56 citations