In vivo exposure to hyperoxia induces DNA damage in a population of alveolar type II epithelial cells

In situ detection of fragmented dna (tunel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note

1995 • 1,171 citations

The type 2 cell as progenitor of alveolar epithelial regeneration. A cytodynamic study in mice after exposure to oxygen.

1974 • 698 citations

Structural and biochemical changes in rat lungs occurring during exposures to lethal and adaptive doses of oxygen.

1980 • 678 citations

In situ end‐labelling detects DNA strand breaks in apoptosis and other physiological and pathological states

1993 • 584 citations

In situ detection of fragmented DNA (tunel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note*1

1995 • 453 citations

Pathogenesis and reversibility of the pulmonary lesions of oxygen toxicity in monkeys. II. Ultrastructural and morphometric studies.

1969 • 420 citations

Mitochondrial DNA repair and aging

2002 • 340 citations

Human Mn-superoxide dismutase in pulmonary epithelial cells of transgenic mice confers protection from oxygen injury.

1992 • 321 citations

Cellular Oxygen Toxicity

1996 • 260 citations

Interleukin-6–Induced Protection in Hyperoxic Acute Lung Injury

2000 • 227 citations

Reactive Oxygen Species and Extracellular Signal-Regulated Kinase 1/2 Mitogen-Activated Protein Kinase Mediate Hyperoxia-Induced Cell Death in Lung Epithelium

2003 • 200 citations

Mitochondrial DNA repair of oxidative damage in mammalian cells

2002 • 194 citations

Microarray Analysis Reveals an Antioxidant Responsive Element-driven Gene Set Involved in Conferring Protection from an Oxidative Stress-induced Apoptosis in IMR-32 Cells

2002 • 193 citations

Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation.

1998 • 178 citations

Induction and rejoining of radiation-induced DNA single-strand breaks: “tail moment” as a function of position in the cell cycle

1993 • 137 citations

Necrotic Cell Death in Response to Oxidant Stress Involves the Activation of the Apoptogenic Caspase-8/Bid Pathway

2003 • 136 citations

GATA-6 and Thyroid Transcription Factor-1 Directly Interact and Regulate Surfactant Protein-C Gene Expression

2002 • 125 citations

ERK activation protects against DNA damage and apoptosis in hyperoxic rat AEC2

1999 • 119 citations

Exposure to Hyperoxia Induces p53 Expression in Mouse Lung Epithelium

1998 • 110 citations

Apoptosis in Neonatal Murine Lung Exposed to Hyperoxia

2001 • 110 citations

Blocking Neutrophil Influx Reduces DNA Damage in Hyperoxia-Exposed Newborn Rat Lung

2002 • 108 citations

Apoptosis and DNA damage in type 2 alveolar epithelial cells cultured from hyperoxic rats

1998 • 105 citations

Mitogen-activated protein kinase pathway mediates hyperoxia-induced apoptosis in cultured macrophage cells

1999 • 104 citations

Hyperoxia-induced Apoptosis Does Not Require Mitochondrial Reactive Oxygen Species and Is Regulated by Bcl-2 Proteins

2002 • 98 citations

Activated Akt Protects the Lung from Oxidant-Induced Injury and Delays Death of Mice

2001 • 97 citations

Oxygen poisoning in mice. Ultrastructural and surfactant studies during exposure and recovery.

1970 • 92 citations

p53-independent induction ofGADD45andGADD153in mouse lungs exposed to hyperoxia

2000 • 68 citations

Overexpression of Manganese Superoxide Dismutase Protects Lung Epithelial Cells against Oxidant Injury

2001 • 66 citations

Immunocytochemical localization of the sites of superoxide dismutase induction by hyperoxia in rat lungs.

1995 • 61 citations

Growth arrest in G1 protects against oxygen‐induced DNA damage and cell death

2002 • 60 citations

Distinct effects of oxygen on surfactant protein B expression in bronchiolar and alveolar epithelium

1992 • 57 citations

Hyperoxia induces Egr‐1 expression through activation of extracellular signal‐regulated kinase 1/2 pathway

2003 • 47 citations

Transgenic and Knockout Models for Studying the Role of Lung Antioxidant Enzymes in Defense against Hyperoxia

2002 • 46 citations

Mitochondrial cytochromecrelease is a key event in hyperoxia-induced lung injury: protection by cyclosporin A

2004 • 44 citations

Protection of Human Lung Cells against Hyperoxia Using the DNA Base Excision Repair Genes hOgg1 and Fpg

2002 • 43 citations

Identification and isolation of mouse type II cells on the basis of intrinsic expression of enhanced green fluorescent protein

2003 • 39 citations

The Influence of High Oxygen Pressures on the Viscosity of Solutions of Sodium Desoxyribonucleic Acid and of Sodium Alginate¹

1957 • 35 citations

Activation of the G2 cell cycle checkpoint enhances survival of epithelial cells exposed to hyperoxia

2003 • 32 citations

Normal Remodeling of the Oxygen-Injured Lung Requires the Cyclin-Dependent Kinase Inhibitor p21Cip1/WAF1/Sdi1

2002 • 27 citations

DNA Oxidation or Apoptosis

2002 • 26 citations

Chromosomal instability in an oxygen-tolerant variant of Chinese hamster ovary cells

1989 • 26 citations

Chromosomal instability and progressive loss of chromosomes in HeLa cells during adaptation to hyperoxic growth conditions

1989 • 25 citations

Mechanism of hyperoxia‐induced chromosomal breakage in chinese hamster cells

1993 • 14 citations