p53-independent induction ofGADD45andGADD153in mouse lungs exposed to hyperoxia

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

DNA Damage and Oxygen Radical Toxicity

1988 • 1,964 citations

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.

1992 • 1,156 citations

Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen

1994 • 941 citations

A Family of Stress-Inducible GADD45-like Proteins Mediate Activation of the Stress-Responsive MTK1/MEKK4 MAPKKK

1998 • 740 citations

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.

1996 • 738 citations

Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents.

1989 • 698 citations

Structural and biochemical changes in rat lungs occurring during exposures to lethal and adaptive doses of oxygen.

1980 • 678 citations

Signals from the Stressed Endoplasmic Reticulum Induce C/EBP-Homologous Protein (CHOP/GADD153)

1996 • 671 citations

In situ end‐labelling detects DNA strand breaks in apoptosis and other physiological and pathological states

1993 • 584 citations

A Mutant p53 That Discriminates between p53-Responsive Genes Cannot Induce Apoptosis

1996 • 283 citations

Genotoxic lipid peroxidation products: their DNA damaging properties and role in formation of endogenous DNA adducts

1998 • 267 citations

Oxygen Toxicity in Mouse Lung: Pathways to Cell Death

1998 • 262 citations

Cellular Oxygen Toxicity

1996 • 260 citations

Analysis of the mammalian gadd45 gene and its response to DNA damage.

1993 • 231 citations

Induction of the mammalian stress response gene GADD153 by oxidative stress: role of AP-1 element

1996 • 202 citations

Genetic toxicology of oxygen

1989 • 198 citations

Hyperosmolality Causes Growth Arrest of Murine Kidney Cells

1998 • 191 citations

Regulation of the C/EBP-related gene gadd153 by glucose deprivation.

1993 • 190 citations

Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation.

1998 • 178 citations

Hyperoxia induces DNA damage in mammalian cells

1993 • 177 citations

The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1.

1996 • 176 citations

Tumor Suppressor p53 Can Participate in Transcriptional Induction of the GADD45 Promoter in the Absence of Direct DNA Binding

1998 • 152 citations

Antisense GADD45 expression results in decreased DNA repair and sensitizes cells to u.v.-irradiation or cisplatin.

1996 • 144 citations

Exposure to Hyperoxia Induces p53 Expression in Mouse Lung Epithelium

1998 • 110 citations

Role of p21Waf1/Cip1/Sdi1 in cell death and DNA repair as studied using a tetracycline-inducible system in p53-deficient cells

1997 • 108 citations

Increased gadd153 messenger RNA level is associated with apoptosis in human leukemic cells treated with etoposide.

1997 • 100 citations

Abrogation of p53 Function Affects gadd Gene Responses to DNA Base-Damaging Agents and Starvation

1996 • 98 citations

Oxygen poisoning in mice. Ultrastructural and surfactant studies during exposure and recovery.

1970 • 92 citations

Accumulation of p21^Cip1/WAF1 during Hyperoxic Lung Injury in Mice

1998 • 64 citations

C/EBPα Regulation of the Growth-Arrest-Associated Gene gadd45

1996 • 63 citations

Induction of p21^WAF/CIP1 during Hyperoxia

1998 • 59 citations

Evidence for Distinct Kinase-Mediated Pathways in gadd Gene Responses

1998 • 22 citations