Mechanism of hyperoxia‐induced chromosomal breakage in chinese hamster cells

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

Ascorbate is an outstanding antioxidant in human blood plasma.

1989 • 1,876 citations

Oxidative Stress: Introductory Remarks

1985 • 979 citations

Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site.

1984 • 849 citations

INTERACTIONS BETWEEN DEOXYRIBONUCLEOTIDE AND DNA SYNTHESIS

1988 • 773 citations

Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain.

1988 • 765 citations

Interaction of lipid peroxidation products with DNA. A review

1988 • 455 citations

Membrane lipid oxidation

1990 • 389 citations

The Relation of Free Radical Production to Hyperoxia

1986 • 382 citations

X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining

1984 • 379 citations

Recent studies of DNA topoisomerases

1987 • 323 citations

Endogenous DNA damage as related to cancer and aging

1989 • 323 citations

A CHO-cell strain having hypersensitivity to mutagens, a defect in DNA strand-break repair, and an extraordinary baseline frequency of sister-chromatid exchange

1982 • 322 citations

Cell culture models for oxidative stress: superoxide and hydrogen peroxide versus normobaric hyperoxia

1992 • 205 citations

Hypothesis: some mutagens directly alter specific chromosomal proteins (DNA topoisomerase II and peripheral proteins) to produce chromosome stickiness, which causes chromosome aberrations

1987 • 180 citations

DNA repair and its inhibition

1984 • 174 citations

Mutagaenic action of ascorbic acid

1976 • 159 citations

Poly ADP-ribosylation: a histone shuttle mechanism in DNA excision repair

1992 • 135 citations

Poly(ADP-ribose)polymerase: a perplexing participant in cellular responses to DNA breakage

1991 • 131 citations

Oxygen-based Free Radical Generation by Ferrous Ions and Deferoxamine

1989 • 101 citations

A comparison of mutation induction at the tk and hprt loci in human lymphoblastoid cells; quantitative differences are due to an additional class of mutations at the autosomal tk locus

1989 • 96 citations

Genes and proteins in oncogenesis

1983 • 96 citations

The genetic consequences of nucleotide precursor pool imbalance in mammalian cells

1984 • 94 citations

Double-strand break repair and G2 block in Chinese hamster ovary cells and their radiosensitive mutants

1985 • 94 citations

Breakage of Chromosomes by Oxygen

1952 • 90 citations

Sensitivity of Chinese hamster ovary mutants defective in DNA double strand break repair to topoisomerase II inhibitors.

1989 • 88 citations

Mutational spectra in human B-cells

1992 • 81 citations

Biochemical and genetic analysis of the Chinese hamster mutants irs1 and irs2 and their comparison to cultured ataxia telangiectasia cells

1990 • 78 citations

Antioxidant activity of l-carnosine, a natural histidine-containing dipeptide in crystalline lens

1989 • 76 citations

Hypochlorous acid potentiates hydrogen peroxide-mediated DNA-strand breaks in human mononuclear leucocytes

1992 • 57 citations

Characterization of an oxygen-tolerant cell line derived from Chinese hamster ovary

1985 • 52 citations

Cytogenetic characterization of the ionizing radiation-sensitive Chinese hamster mutant irs1

1991 • 50 citations

Potentiation of chromosomal alterations by inhibitors of DNA repair.

1984 • 49 citations

Induction of sister chromatid exchanges in chinese hamster cells by the reducing agents bisulfite and ascorbic acid

1979 • 40 citations

Chromosomal damage and mutations after exposure of chinese hamster cells to high concentrations of oxygen

1978 • 39 citations

Effects of lethal exposure to hyperoxia and to hydrogen peroxide on NAD(H) and ATP pools in Chinese hamster ovary cells

1989 • 36 citations

Inhibition of DNA repair by inhibitors of nuclear ADP-ribosyl transferase.

1984 • 33 citations

Effect of antioxidants on hyperoxia-induced chromosomal breakage in Chinese hamster ovary cells: protection by carnosine

1991 • 29 citations

Chromosomal instability in an oxygen-tolerant variant of Chinese hamster ovary cells

1989 • 26 citations

Free Radical Mediated Cytotoxicity of Desferrioxamine

1989 • 21 citations

Effect of iron chelators on the cytotoxic and genotoxic action of hyperoxia in Chinese hamster ovary cells

1992 • 17 citations

Oxygen-induced cytogenetic instability in normal human lymphocytes

1986 • 16 citations

Effect of hyperoxia-induced oxidative stress on the cytotoxicity and mutagenicity of UV and EMS in Chinese hamster ovary cells

1992 • 1 citations