Growth arrest in G1 protects against oxygen‐induced DNA damage and cell death

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing

2000 • 4,715 citations

Reactive oxygen species in cell signaling

2000 • 2,844 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

Importance of SE-glutathione peroxidase, catalase, and CU/ZN-SOD for cell survival against oxidative stress

1994 • 1,178 citations

Evaluation of 2′,7′-Dichlorofluorescin and Dihydrorhodamine 123 as Fluorescent Probes for Intracellular H2O2 in Cultured Endothelial Cells

1993 • 1,126 citations

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

1995 • 959 citations

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.

1995 • 938 citations

Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-α

1978 • 904 citations

Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair

1994 • 657 citations

A checkpoint regulates the rate of progression through S phase in S. cerevisiae in Response to DNA damage

1995 • 596 citations

Induction of cellular p53 activity by DNA-damaging agents and growth arrest.

1993 • 440 citations

Enzymatic Processing of Radiation-Induced Free Radical Damage in DNA

1998 • 330 citations

Caffeine Abolishes the Mammalian G2/M DNA Damage Checkpoint by Inhibiting Ataxia-Telangiectasia-mutated Kinase Activity

2000 • 278 citations

Apoptosis Induced by Transforming Growth Factor-β in Fetal Hepatocyte Primary Cultures

1996 • 262 citations

Cellular Oxygen Toxicity

1996 • 260 citations

The DNA Repair Endonuclease XPG Binds to Proliferating Cell Nuclear Antigen (PCNA) and Shares Sequence Elements with the PCNA-binding Regions of FEN-1 and Cyclin-dependent Kinase Inhibitor p21

1997 • 236 citations

Hydroxyurea

1975 • 234 citations

RB-Dependent S-Phase Response to DNA Damage

2000 • 224 citations

Cell culture models for oxidative stress: superoxide and hydrogen peroxide versus normobaric hyperoxia

1992 • 205 citations

Hyperoxia induces DNA damage in mammalian cells

1993 • 177 citations

The Action of Caffeine on X-Irradiated HeLa Cells: III. Enhancement of X-Ray-Induced Killing during G 2 Arrest

1978 • 160 citations

Repair Defect in p21 WAF1/CIP1 -/- human cancer cells.

1996 • 158 citations

Transforming Growth Factor- β₁ Is a Potent Inhibitor of Glutathione Synthesis in the Lung Epithelial Cell Line A549: Transcriptional Effect on the GSH Rate-limiting Enzyme γ -Glutamylcysteine Synthetase

1997 • 153 citations

p53 accumulates but is functionally impaired when DNA synthesis is blocked

2001 • 144 citations

Induction and rejoining of radiation-induced DNA single-strand breaks: “tail moment” as a function of position in the cell cycle

1993 • 137 citations

Effect of oxygen tension on HeLa cell growth.

1960 • 111 citations

The Cyclin-Dependent Kinase Inhibitor p21 Protects the Lung from Oxidative Stress

2001 • 111 citations

p53 modulates base excision repair activity in a cell cycle-specific manner after genotoxic stress.

2001 • 102 citations

Abrogation of p53 Function Affects gadd Gene Responses to DNA Base-Damaging Agents and Starvation

1996 • 98 citations

Characterization of p21Cip1/Waf1 peptide domains required for cyclin E/Cdk2 and PCNA interaction.

1996 • 87 citations

Altered Regulation of G1 Cyclins in Oxidant-induced Growth Arrest of Lung Alveolar Epithelial Cells

1996 • 86 citations

p53-Dependent Induction of p21Cip1/WAF1/Sdi1 Protects against Oxygen-Induced Toxicity

2001 • 81 citations

Mutagenicity of metabolic oxygen radicals in mammalian cell cultures

1994 • 73 citations

Oxygen Induces S-Phase Growth Arrest and Increases p53 and p21^WAF1/CIP1Expression in Human Bronchial Smooth-Muscle Cells

1999 • 65 citations

The Effects of Hyperoxic Injury and Antioxidant Vitamins on Death and Proliferation of Human Small Airway Epithelial Cells

1998 • 62 citations

Redox Paradox: Effect of N-Acetylcysteine and Serum on Oxidation Reduction–Sensitive Mitogen-Activated Protein Kinase Signaling Pathways

2001 • 56 citations

The role of p21^CIP1/WAF1 in growth of epithelial cells exposed to hyperoxia

2001 • 47 citations

Nitrogen Dioxide Induces Death in Lung Epithelial Cells in a Density-Dependent Manner

2001 • 47 citations

Expression of NAD(P)H:Quinone Oxidoreductase 1 in HeLa Cells

2001 • 47 citations

Chromosomal damage and mutations after exposure of chinese hamster cells to high concentrations of oxygen

1978 • 39 citations

Conversion of Monofunctional DNA Adducts of cis-Diamminedichloroplatinum (II) to Bifunctional Lesions

1989 • 37 citations

The Influence of High Oxygen Pressures on the Viscosity of Solutions of Sodium Desoxyribonucleic Acid and of Sodium Alginate¹

1957 • 35 citations

A stable O2-resistant cell line: role of lipid peroxidation byproducts in O2-mediated injury

1992 • 32 citations

Inhibition of DNA synthesis by TGF-β1 coincides with inhibition of phosphorylation and cytoplasmic translocation of p53 protein

1992 • 30 citations

Transforming growth factor-β1 enhances the lethal effects of DNA-damaging agents in a human lung-cancer cell line

1997 • 30 citations

Effect of iron chelators on the cytotoxic and genotoxic action of hyperoxia in Chinese hamster ovary cells

1992 • 17 citations

A phase contrast cinemicrographic analysis of elevated oxygen tension effects on cell dynamics in strain L cells

1970 • 6 citations