Protection of Human Lung Cells against Hyperoxia Using the DNA Base Excision Repair Genes hOgg1 and Fpg

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

DNA Repair and Mutagenesis

2006 • 4,725 citations

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

1997 • 1,762 citations

Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage

1999 • 792 citations

DNA REPAIR IN EUKARYOTES

1996 • 682 citations

Surfactant Proteins A and D and Pulmonary Host Defense

2001 • 640 citations

Cloning and characterization of hOGG1 , a human homolog of the OGG1 gene of Saccharomyces cerevisiae

1997 • 586 citations

The base excision repair pathway

1995 • 536 citations

Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase

1997 • 477 citations

Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis: The role of dna base damage

1990 • 364 citations

Homogeneous Escherichia coli FPG protein. A DNA glycosylase which excises imidazole ring-opened purines and nicks DNA at apurinic/apyrimidinic sites.

1990 • 347 citations

Mmh / Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice

2000 • 342 citations

Physiology of oxygen radicals

1986 • 330 citations

The Role of DNA Single- and Double-Strand Breaks in Cell Killing by Ionizing Radiation

1998 • 322 citations

Pulmonary Oxygen Toxicity

1985 • 293 citations

Oxygen Toxicity in Mouse Lung: Pathways to Cell Death

1998 • 262 citations

Cellular Oxygen Toxicity

1996 • 260 citations

Cell cycle control, checkpoint mechanisms, and genotoxic stress.

1999 • 252 citations

Human Thymine DNA Glycosylase Binds to Apurinic Sites in DNA but Is Displaced by Human Apurinic Endonuclease 1

1999 • 251 citations

Substrate Specificity and Reaction Mechanism of Murine 8-Oxoguanine-DNA Glycosylase

2000 • 192 citations

Oxidant injury of lung parenchymal cells.

1981 • 185 citations

Iron is the intracellular metal involved in the production of DNA damage by oxygen radicals

1991 • 158 citations

Design of 5′ Untranslated Sequences in Retroviral Vectors Developed for Medical Use

1999 • 155 citations

Regulation of intracellular localization of human MTH1, OGG1, and MYH proteins for repair of oxidative DNA damage

2001 • 153 citations

Kinetics of excision of purine lesions from DNA by Escherichia coli Fpg protein

1997 • 153 citations

Excision of 5'-terminal deoxyribose phosphate from damaged DNA is catalyzed by the Fpg protein of Escherichia coli.

1992 • 147 citations

Enhanced Mitochondrial DNA Repair and Cellular Survival after Oxidative Stress by Targeting the Human 8-Oxoguanine Glycosylase Repair Enzyme to Mitochondria

2000 • 142 citations

Physical and Biological Interface Dose Effects in Tissue due to X-Ray-Induced Release of Secondary Radiation from Metallic Gold Surfaces

1998 • 130 citations

DNA damage and cell cycle checkpoints in hyperoxic lung injury: braking to facilitate repair

2001 • 121 citations

SUPEROXIDE DISMUTASE

1974 • 114 citations

Oxidative base damage to DNA: specificity of base excision repair enzymes

2000 • 114 citations

Distinct Repair Activities of Human 7,8-Dihydro-8-oxoguanine DNA Glycosylase and Formamidopyrimidine DNA Glycosylase for Formamidopyrimidine and 7,8-Dihydro-8-oxoguanine

2000 • 113 citations

Substrate specificity of the Ogg1 protein of Saccharomyces cerevisiae: excision of guanine lesions produced in DNA by ionizing radiation- or hydrogen peroxide/metal ion-generated free radicals

1998 • 111 citations

The Cyclin-Dependent Kinase Inhibitor p21 Protects the Lung from Oxidative Stress

2001 • 111 citations

Exposure to Hyperoxia Induces p53 Expression in Mouse Lung Epithelium

1998 • 110 citations

Hyperoxia‐induced Cell Death in the Lung‐the Correlation of Apoptosis, Necrosis, and Inflammation

1999 • 108 citations

Cell-Specific Delivery of Bacteriophage-Encapsidated Ricin A Chain

1995 • 101 citations

Monitoring and Signaling of Radiation-Induced Damage in Mammalian Cells

1998 • 100 citations

Breakage of Chromosomes by Oxygen

1952 • 90 citations

Oxygen radical-induced mitochondrial DNA damage and repair in pulmonary vascular endothelial cell phenotypes

2001 • 79 citations

Review of mammalian DNA repair and translational implications.

2000 • 75 citations

OXYGEN TOXICITY OF THE LUNG: AN UPDATE

1982 • 70 citations

The Effects of Hyperoxic Injury and Antioxidant Vitamins on Death and Proliferation of Human Small Airway Epithelial Cells

1998 • 62 citations

Genetically engineered macrophages expressing IFN-γ restore alveolar immune function inscidmice

2001 • 58 citations

Retrovirus-mediated expression of the base excision repair proteins, formamidopyrimidine DNA glycosylase or human oxoguanine DNA glycosylase, protects hematopoietic cells from N,N',N"-triethylenethiophosphoramide (thioTEPA)-induced toxicity in vitro and in vivo.

2001 • 57 citations

MUTAGENIC EFFECTS OF HIGH OXYGEN TENSIONS ON ESCHERICHIA COLI

1957 • 56 citations

Bleomycin-Mediated Pulmonary Toxicity

2000 • 54 citations

Human MMH (OGG1) Type 1a Protein Is a Major Enzyme for Repair of 8-Hydroxyguanine Lesions in Human Cells

1999 • 50 citations

Escherichia coliFPG and human OGG1 reduce DNA damage and cytotoxicity by BCNU in human lung cells

2002 • 44 citations

Reduction of BCNU toxicity to lung cells by high-level expression ofO⁶-methylguanine-DNA methyltransferase

2001 • 39 citations

DNA repair and gene therapy: Implications for translational uses

2000 • 38 citations

Expression of Yeast Apurinic/Apyrimidinic Endonuclease (APN1) Protects Lung Epithelial Cells From Bleomycin Toxicity

2001 • 33 citations

Increased resistance to N,N',N"-triethylenethiophosphoramide (thiotepa) in cells expressing the Escherichia coli formamidopyrimidine-DNA glycosylase.

1996 • 32 citations

Protection of mammalian cells against chemotherapeutic agents thiotepa, 1,3-N,N'-bis(2-chloroethyl)-N-nitrosourea, and mafosfamide using the DNA base excision repair genes Fpg and alpha-hOgg1: implications for protective gene therapy applications.

2001 • 29 citations

Properties of Alveolar Cells and Tissues That Strengthen Alveolar Defenses

1970 • 26 citations

Chromosomal instability in an oxygen-tolerant variant of Chinese hamster ovary cells

1989 • 26 citations

Oxygen-mediated impairment of human pulmonary endothelial cell growth: evidence for a specific threshold of toxicity.

1989 • 25 citations

Role of Cyclins in Epithelial Response to Oxidants

2001 • 24 citations

Effect of iron chelators on the cytotoxic and genotoxic action of hyperoxia in Chinese hamster ovary cells

1992 • 17 citations

Acute respiratory failure induced by bleomycin and hyperoxia: Pulmonary edema, cell kinetics, and morphology

1987 • 13 citations