Cellular Oxygen Toxicity

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

Peroxynitrite‐mediated oxidative protein modifications

1995 • 611 citations

The role of DNA fragmentation in apoptosis

1995 • 608 citations

Oxidants in mitochondria: from physiology to diseases

1995 • 543 citations

Cell and tissue responses to oxidative damage.

1993 • 492 citations

Differential susceptibility of plasma proteins to oxidative modification: Examination by western blot immunoassay

1994 • 464 citations

Aconitase is a sensitive and critical target of oxygen poisoning in cultured mammalian cells and in rat lungs.

1994 • 415 citations

Chapter 2 Assays of Cell Viability: Discrimination of Cells Dying by Apoptosis

1994 • 354 citations

Free Radical-Mediated Lipid Peroxidation in Cells: Oxidizability Is a Function of Cell Lipid bis-Allylic Hydrogen Content

1994 • 350 citations

The role of intracellular oxidants in apoptosis

1995 • 294 citations

Oxidative stress-induced apoptosis prevented by trolox

1994 • 266 citations

Cell culture models for oxidative stress: superoxide and hydrogen peroxide versus normobaric hyperoxia

1992 • 205 citations

Hydrogen peroxide as a mediator of programmed cell death in the blastocyst

1991 • 205 citations

Antioxidant status and lipid peroxidation in patients infected with HIV

1994 • 191 citations

Endonuclease-induced DNA damage and cell death in oxidant injury to renal tubular epithelial cells.

1992 • 182 citations

Regulation of antioxidant enzymes in lung after oxidant injury.

1994 • 123 citations

Respiratory failure and stimulation of glycolysis in Chinese hamster ovary cells exposed to normobaric hyperoxia.

1990 • 100 citations

Bcl‐2 protects from oxidative damage and apoptotic cell death without interfering with activation of NF‐κB by TNF

1994 • 98 citations

Mechanisms of cellular resistance to hydrogen peroxide, hyperoxia, and 4-hydroxy-2-nonenal toxicity: The significance of increased catalase activity in H2O2-resistant fibroblasts

1992 • 89 citations

HIV Gene Expression Enhances T Cell Susceptibility to Hydrogen Peroxide-Induced Apoptosis

1993 • 77 citations

An evaluation of renal tubular DNA laddering in response to oxygen deprivation and oxidant injury.

1994 • 75 citations

Simultaneous detection of TDT-mediated dUTP-biotin nick end-labeling (TUNEL)-positive cells and multiple immunohistochemical markers in single tissue sections.

1995 • 73 citations

Mutagenicity of metabolic oxygen radicals in mammalian cell cultures

1994 • 73 citations

Modulation of inflammatory arthritis by inhibition of poly(ADP ribose) polymerase

1995 • 63 citations

Increased expression of tissue inhibitor of metalloproteinases (TIMP-I) and metallothionein in murine lungs after hyperoxic exposure.

1994 • 57 citations

Inhibition of lung epithelial cell proliferation by hyperoxia. Posttranscriptional regulation of proliferation-related genes.

1992 • 51 citations

Effects of lethal exposure to hyperoxia and to hydrogen peroxide on NAD(H) and ATP pools in Chinese hamster ovary cells

1989 • 36 citations

Oxygen Toxicity

1992 • 36 citations

A Critical Role for Thiol, But Not ATP, Depletion in 95% O2-Mediated Injury of Preterm Pneumocytes in Vitro

1994 • 27 citations

Chromosomal instability in an oxygen-tolerant variant of Chinese hamster ovary cells

1989 • 26 citations

Paraquat induces irreversible actin cytoskeleton disruption in cultured human lung cells

1994 • 24 citations

Species difference in the resistibility of embryonic fibroblasts against oxygen-induced growth inhibition

1995 • 14 citations

Fibroblast Inhibition Does Not Promote Normal Lung Repair After Hyperoxia

1994 • 13 citations

Effect of ICRF-187 on the pulmonary damage induced by hyperoxia in the rat

1992 • 12 citations