Human lymphoblasts contain DNA glycosylase activity excising N-3 and N-7 methyl and ethyl purines but not O6-alkylguanines or 1-alkyladenines.

The Chemical Effects ofNucleic Acid Alkylation and Their Relation to Mutagenesis and Carcinogen esis

1975 • 446 citations

All oxygens in nucleic acids react with carcinogenic ethylating agents

1976 • 311 citations

N-nitroso alkylating agents: formation and persistence of alkyl derivatives in mammalian nucleic acids as contributing factors in carcinogenesis.

1979 • 276 citations

Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA

1979 • 260 citations

Properties of 3-methyladenine-DNA glycosylase from Escherichia coli

1978 • 190 citations

Molecular and cellular mechanisms associated with pulse-carcinogenesis in the rat nervous system by ethylnitrosourea: ethylation of nucleic acids and elimination rates of ethylated bases from the DNA of different tissues

1974 • 181 citations

Specific excision of methylation products from DNA of Escherichia coli treated with N-methyl-N′-nitro-N-nitrosoguanidine

1970 • 173 citations

Two enzymes are required for strand incision in repair of alkylated DNA

1977 • 153 citations

The Enzymatic Release of O ⁶ -methylguanine and 3-methyladenine from DNA Reacted with the Carcinogen N -methyl- N -nitrosourea

1974 • 138 citations

Oxygens in DNA are main targets for ethylnitrosourea in normal and xeroderma pigmentosum fibroblasts and fetal rat brain cells

1978 • 113 citations

Repair of DNA damaged by alkylating carcinogens is defective in xeroderma pigmentosum-derived fibroblasts

1977 • 109 citations

Methylated purines in the deoxyribonucleic acid of various Syrian-golden-hamster tissues after administration of a hepatocarcinogenic dose of dimethylnitrosamine

1976 • 98 citations

Evidence for removal at different rates of O-ethyl pyrimidines and ethylphosphotriesters in two human fibroblast cell lines

1979 • 86 citations

Removal of minor methylation products 7-methyl adenine and 3-methylguanine from DNA ofescherichia coli treated with dimethyl sulphate

1976 • 84 citations

Enzymatic removal of O6-methylguanine from DNA by mammalian cell extracts

1978 • 83 citations

The stability of methylated purines and of methylphosphotriesters in the DNA of V79 cells after treatment with N-methyl-N-nitrosourea

1979 • 80 citations

O²- and O⁴-Alkyl pyrimidine nucleosides: stability of the glycosyl bond and of the alkyl group as a function of pH

1978 • 74 citations

Partial purification and characterization of a human 3-methyladenine-DNA glycosylase

1979 • 54 citations

The Excision of N‐Methyl‐N‐nitrosourea‐Induced Lesions from the DNA of Chinese Hamster Cells as Measured by the Loss of Sites Sensitive to an Enzyme Extract that Excises 3‐Methylpurines but not O⁶‐Methylguanine

1979 • 21 citations

Actions of human DNA glycosylases on uracil-containing DNA, methylated DNA and their reconstituted chromatins

1979 • 17 citations

Formation of relatively persistent O²‐ethylthymidine by diethylnitrosamine in rat liver DNA

1979 • 13 citations

3-Methyladenine-DNA glycosylase: A probe for determining alkylation damage and repair in human fibroblasts

1979 • 10 citations