Interactions between NO and reactive oxygen species: pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

1994 • 2,753 citations

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

1996 • 2,456 citations

Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries

1986 • 2,422 citations

Abnormal Endothelium-Dependent Vascular Relaxation in Patients with Essential Hypertension

1990 • 2,388 citations

Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide

1991 • 2,215 citations

Hypercholesterolemia increases endothelial superoxide anion production.

1993 • 1,799 citations

Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors

1998 • 1,475 citations

Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes.

1991 • 1,161 citations

Cellular and molecular mechanisms of endothelial cell dysfunction.

1997 • 1,064 citations

Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans.

1990 • 1,020 citations

Impaired Neurogenic and Endothelium-Mediated Relaxation of Penile Smooth Muscle from Diabetic Men with Impotence

1989 • 960 citations

Role of Superoxide in Angiotensin II–Induced but Not Catecholamine-Induced Hypertension

1997 • 831 citations

Endothelium-dependent vasodilation is attenuated in patients with heart failure.

1991 • 788 citations

p22 Is a Critical Component of the Superoxide-generating NADH/NADPH Oxidase System and Regulates Angiotensin IIinduced Hypertrophy in Vascular Smooth Muscle Cells

1996 • 768 citations

Generation of superoxide by purified brain nitric oxide synthase.

1992 • 765 citations

Does superoxide underlie the pathogenesis of hypertension?

1991 • 760 citations

Hypertension and the Pathogenesis of Atherosclerosis

1995 • 760 citations

Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury.

1996 • 730 citations

Inhibition of Mitochondrial Electron Transport by Peroxynitrite

1994 • 697 citations

Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension.

1993 • 685 citations

Pathological implications of nitric oxide, superoxide and peroxynitrite formation

1993 • 679 citations

Superoxide and peroxynitrite inatherosclerosis.

1994 • 674 citations

Superoxide Production in Vascular Smooth Muscle Contributes to Oxidative Stress and Impaired Relaxation in Atherosclerosis

1998 • 631 citations

Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide.

1994 • 596 citations

Free radicals mediate endothelial cell dysfunction caused by elevated glucose

1992 • 566 citations

Endothelial function in chronic congestive heart failure

1992 • 562 citations

Increased Oxidative Stress in Patients With Congestive Heart Failure 11This study was supported by a grant jointly sponsored by the Medical Research Council of Canada, Ottawa and Bayer Pharmaceuticals, Etobicoke, Ontario, Canada.

1998 • 561 citations

p22phox mRNA Expression and NADPH Oxidase Activity Are Increased in Aortas From Hypertensive Rats

1997 • 555 citations

Ca2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase

1992 • 534 citations

Endothelial dysfunction of the coronary microvasculature is associated with coronary blood flow regulation in patients with early atherosclerosis.

1991 • 531 citations

Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta.

1990 • 527 citations

Normalization of Blood Pressure and Renal Vascular Resistance in SHR With a Membrane-Permeable Superoxide Dismutase Mimetic

1998 • 500 citations

Native Low-Density Lipoprotein Increases Endothelial Cell Nitric Oxide Synthase Generation of Superoxide Anion

1995 • 479 citations

Endothelium-dependent dilation of the coronary microvasculature is impaired in dilated cardiomyopathy.

1990 • 444 citations

Leukocyte-endothelial interaction is augmented by high glucose concentrations and hyperglycemia in a NF-kB-dependent fashion.

1998 • 434 citations

Expression of phagocyte NADPH oxidase components in human endothelial cells

1996 • 432 citations

Divergent Effects of Serotonin on Coronary-Artery Dimensions and Blood Flow in Patients with Coronary Atherosclerosis and Control Patients

1991 • 420 citations

Atherosclerosis impairs endothelium-dependent vascular relaxation to acetylcholine and thrombin in primates.

1986 • 406 citations

Chronic treatment with polyethylene-glycolated superoxide dismutase partially restores endothelium-dependent vascular relaxations in cholesterol-fed rabbits.

1991 • 403 citations

Impaired endothelium-mediated vasodilation in the peripheral vasculature of patients with congestive heart failure

1992 • 400 citations

George E. Brown memorial lecture. Oxygen radicals in cerebral vascular injury.

1985 • 393 citations

The reaction of NO· with O2·− and HO2·−: A pulse radiolysis study

1995 • 389 citations

Superoxide Anion From the Adventitia of the Rat Thoracic Aorta Inactivates Nitric Oxide

1998 • 387 citations

Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits.

1996 • 375 citations

Vitamin C Improves Endothelium-Dependent Vasodilation in Forearm Resistance Vessels of Humans With Hypercholesterolemia

1997 • 360 citations

Review of Alterations in Endothelial Nitric Oxide Production in Diabetes

1998 • 357 citations

Attenuation of endothelium-dependent relaxation in aorta from diabetic rats

1986 • 350 citations

Tumour necrosis factor α activates a p22phox-based NADH oxidase in vascular smooth muscle

1998 • 313 citations

Role of Superoxide in the Depressed Nitric Oxide Production by the Endothelium of Genetically Hypertensive Rats

1995 • 304 citations

Peroxynitrite induces both vasodilatation and impaired vascular relaxation in the isolated perfused rat heart.

1994 • 300 citations

Evidence of oxidative stress in chronic heart failure in humans

1993 • 277 citations

Regulation of protein kinase C by lysophospholipids. Potential role in signal transduction.

1988 • 270 citations

Pathophysiological concentrations of glucose promote oxidative modification of low density lipoprotein by a superoxide-dependent pathway.

1994 • 254 citations

Formation of free nitric oxide from l-arginine by nitric oxide synthase: direct enhancement of generation by superoxide dismutase.

1994 • 247 citations

Direct In Situ Measurement of Nitric Oxide in Mesenteric Resistance Arteries

1996 • 244 citations

Endothelial Dysfunction in Atherosclerosis

1996 • 243 citations

Vascular effects of oxygen-derived free radicals

1988 • 242 citations

Peroxynitrite, a product of superoxide and nitric oxide, produces coronary vasorelaxation in dogs.

1994 • 232 citations

Endothelium-dependent vascular relaxation is abnormal in the coronary microcirculation of atherosclerotic primates.

1990 • 232 citations

Pathophysiological consequences of atherosclerosis extend into the coronary microcirculation. Restoration of endothelium-dependent responses by L-arginine.

1992 • 230 citations

Improvement in endothelial function by angiotensin converting enzyme inhibition in insulin-dependent diabetes mellitus.

1997 • 220 citations

Pulsatile Stretch Stimulates Superoxide Production and Activates Nuclear Factor-κB in Human Coronary Smooth Muscle

1997 • 206 citations

Superoxide generation and reversal of acetylcholine-induced cerebral arteriolar dilation after acute hypertension.

1985 • 205 citations

Diminished endothelium-derived relaxing factor activity in an experimental model of chronic heart failure.

1991 • 204 citations

Redox control of vascular smooth muscle proliferation

1998 • 200 citations

Pulsatile Stretch Stimulates Superoxide Production in Human Aortic Endothelial Cells

1997 • 186 citations

Oxygen free radicals in essential hypertension

1992 • 182 citations

Diabetic-induced endothelial dysfunction in rat aorta: role of hydroxyl radicals

1997 • 180 citations

Cyclic strain induces an oxidative stress in endothelial cells

1997 • 179 citations

Effect of antioxidant vitamins on low density lipoprotein oxidation and impaired endothelium-dependent vasodilation in patients with hypercholesterolemia

1994 • 173 citations

NADH Oxidase Activity of Human Xanthine Oxidoreductase

1997 • 172 citations

Superoxide dismutase is a prophylactic against alloxan diabetes

1981 • 166 citations

Vasodilator dysfunction in aged spontaneously hypertensive rats: changes in NO synthase III and soluble guanylyl cyclase expression, and in superoxide anion production

1998 • 166 citations

Regulation of spontaneous EDRF release in diabetic rat aorta by oxygen free radicals

1992 • 161 citations

Development of Autoimmune Diabetes in NOD Mice Is Associated With the Formation of Peroxynitrite in Pancreatic Islet β-Cells

1997 • 149 citations

Lysophosphatidylcholine increases vascular superoxide anion production via protein kinase C activation.

1994 • 139 citations

Cholesterol feeding impairs endothelium-dependent relaxation of rabbit aorta

1985 • 125 citations

Videomicroscopic demonstration of defective cholinergic arteriolar vasodilation in atherosclerotic rabbit.

1988 • 122 citations

A relative deficit in antioxidant reserve may contribute in cardiac failure.

1990 • 119 citations

Inhibition of Rat Cardiac Muscle Contraction and Mitochondrial Respiration by Endogenous Peroxynitrite Formation During Posthypoxic Reoxygenation

1998 • 114 citations

Role of nitric oxide and peroxynitrite in the cytokine-induced sustained myocardial dysfunction in dogs in vivo.

1998 • 114 citations

Oxy free radical system in heart failure and therapeutic role of oral vitamin E

1996 • 114 citations

Increased NADH Oxidase Activity in the Retina of the BBZ/WOR Diabetic Rat

1998 • 112 citations

Peroxynitrite-induced cardiac myocyte injury

1996 • 111 citations

Cytochrome b-558 α-subunit cloning and expression in rat aortic smooth muscle cells

1995 • 110 citations

Sensitivity of human pancreatic islets to peroxynitrite-induced cell dysfunction and death

1996 • 106 citations

Peroxynitrite stimulates vascular smooth muscle cell cyclic GMP synthesis

1995 • 104 citations

Peroxynitrite impairs cardiac contractile function by decreasing cardiac efficiency

1997 • 103 citations

Alterations in nitric oxide synthase activity, superoxide anion generation, and platelet aggregation in systemic hypertension, and effects of celiprolol

1994 • 94 citations

Increased oxidative stress in dilated cardiomyopathic heart failure

1998 • 86 citations

Free radical yields from the homolysis of peroxynitrous acid

1992 • 86 citations

Xanthine oxidoreductase is asymmetrically localised on the outer surface of human endothelial and epithelial cells in culture

1998 • 76 citations

Role of oxygen-derived free radicals in acute angiotensin II--induced hypertensive vascular disease in the rat.

1990 • 76 citations

Effects of Afterload-Reducing Drugs on Pathogenesis of Antioxidant Changes and Congestive Heart Failure in Rats

1997 • 74 citations

[Regulation of protein kinase C by lysophospholipids].

1991 • 71 citations

Alterations of the vascular and the myocardial guanylate cyclase/cGMP-system induced by long-term hypertension in rats

1998 • 55 citations

Superoxide dismutase decreases mortality, blood pressure, and cerebral blood flow responses induced by acute hypertension in rats.

1991 • 26 citations

Intracellular effects of free radicals and reactive oxygen species in cardiac muscle.

1995 • 16 citations

Oxygen Free Radicals and Heart Failure

1988 • 15 citations