Redox control of vascular smooth muscle proliferation

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

1994 • 2,753 citations

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

1996 • 2,456 citations

Hypercholesterolemia increases endothelial superoxide anion production.

1993 • 1,799 citations

Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

1997 • 1,582 citations

Oxidants as Stimulators of Signal Transduction

1997 • 1,380 citations

Superoxide and hydrogen peroxide in relation to mammalian cell proliferation

1995 • 1,185 citations

Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells.

1993 • 1,079 citations

Role of Superoxide in Angiotensin II–Induced but Not Catecholamine-Induced Hypertension

1997 • 831 citations

p22 Is a Critical Component of the Superoxide-generating NADH/NADPH Oxidase System and Regulates Angiotensin IIinduced Hypertrophy in Vascular Smooth Muscle Cells

1996 • 768 citations

Does superoxide underlie the pathogenesis of hypertension?

1991 • 760 citations

p38 Mitogen-activated Protein Kinase Is a Critical Component of the Redox-sensitive Signaling Pathways Activated by Angiotensin II

1998 • 657 citations

Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression.

1992 • 653 citations

Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues.

1988 • 610 citations

p22phox mRNA Expression and NADPH Oxidase Activity Are Increased in Aortas From Hypertensive Rats

1997 • 555 citations

NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium

1994 • 546 citations

Differential Activation of Mitogen-Activated Protein Kinases by H ₂ O ₂ and O ₂ ⁻ in Vascular Smooth Muscle Cells

1995 • 416 citations

Chronic treatment with polyethylene-glycolated superoxide dismutase partially restores endothelium-dependent vascular relaxations in cholesterol-fed rabbits.

1991 • 403 citations

Cytochrome b ₅₅₈ : the Flavin-Binding Component of the Phagocyte NADPH Oxidase

1992 • 384 citations

Tumour necrosis factor α activates a p22phox-based NADH oxidase in vascular smooth muscle

1998 • 313 citations

Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug.

1996 • 312 citations

An NADPH oxidase superoxide-generating system in the rabbit aorta

1995 • 295 citations

Induction of Apoptosis by Pyrrolidinedithiocarbamate and N-Acetylcysteine in Vascular Smooth Muscle Cells

1996 • 248 citations

Identification of a superoxide-generating NADPH oxidase system in human fibroblasts

1991 • 233 citations

Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice.

1994 • 228 citations

Dietary probucol preserves endothelial function in cholesterol-fed rabbits by limiting vascular oxidative stress and superoxide generation.

1995 • 202 citations

Reactive oxygen species induce apoptosis of vascular smooth muscle cell

1997 • 188 citations

Sites of superoxide anion production detected by lucigenin in calf pulmonary artery smooth muscle

1994 • 165 citations

Xanthine oxidase activity in rat pulmonary artery endothelial cells and its alteration by activated neutrophils.

1989 • 150 citations

Linoleic acid and its metabolites, hydroperoxyoctadecadienoic acids, stimulate c-Fos, c-Jun, and c-Myc mRNA expression, mitogen-activated protein kinase activation, and growth in rat aortic smooth muscle cells.

1995 • 143 citations

Hydrogen peroxide-induced c-fos expression is mediated by arachidonic acid release: role of protein kinase C

1993 • 137 citations

The superoxide-generating oxidase of leucocytes. NADPH-dependent reduction of flavin and cytochrome b in solubilized preparations

1984 • 128 citations

Properties of a superoxide anion-generating microsomal NADH oxidoreductase, a potential pulmonary artery PO2 sensor

1994 • 127 citations

Hydrogen peroxide stimulates transcription of c-jun in vascular smooth muscle cells: role of arachidonic acid.

1993 • 123 citations

Reactive Oxygen Intermediates Mediate Angiotensin II-induced c-Jun•c-Fos Heterodimer DNA Binding Activity and Proliferative Hypertrophic Responses in Myogenic Cells

1995 • 122 citations

Cytochrome b-558 α-subunit cloning and expression in rat aortic smooth muscle cells

1995 • 110 citations

Hydrogen peroxide-and fetal bovine serum-induced DNA synthesis in vascular smooth muscle cells: positive and negative regulation by protein kinase C isoforms

1995 • 81 citations

Superoxide anion production by rabbit thoracic aorta: effect of endothelium-derived nitric oxide

1993 • 77 citations

Effect of Active Oxygen Species on Intimal Proliferation in Rat Aorta after Arterial Injury

1996 • 43 citations

Superoxide production in the isolated rabbit aorta and the effect of alloxan, indomethacin and nitrovasodilators.

1991 • 20 citations